Comparison between ureteroscopy with holmium:YAG laser lithotripsy and extracorporeal shock-wave lithotripsy for ureteral calculi
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摘要: 目的: 比较输尿管镜钬激光碎石术(LL)与体外冲击波碎石术(ESWL)治疗输尿管结石的临床疗效和安全性。方法: 总结2008年1月~2012年9月于我院泌尿外科住院治疗的465例输尿管结石患者的临床资料,采用LL治疗输尿管结石196例,其中结石直径>1.0 cm者104例, ≤ 1.0 cm者92例;采用ESWL治疗269例,其中结石直径>1.0 cm者128例, ≤ 1.0cm者141例。比较两者治疗输尿管结石的手术时间、术后3个月结石排净率及手术并发症发生率的差异。结果: LL组治疗结石直径>1.0 cm和 ≤ 1.0 cm的平均手术时间均明显少于ESWL组相应的平均手术时间,差异有统计学意义(P<0.01);对直径>1.0 cm的输尿管结石,LL组术后3个月结石排净率为93.3%,明显高于ESWL组的69.5%,差异有统计学意义(P<0.01);而对于直径 ≤ 1.0 cm的输尿管结石,LL组和ESWL组术后3个月结石排净率分别为91.3%和89.4%,差异无统计学意义(P>0.05)。ESWL治疗上段结石的有效率为87.2%,明显高于中下段结石74.3%,差异有统计学意义(P<0.01);而LL组的有效率分别为92.0%和92.6%,差异无统计学意义(P>0.05)。LL组并发症发生率为4.6%,ESWL组无明显并发症发生。结论: 综合考虑,对直径 ≤ 1.0 cm的输尿管结石,尤其是上段结石,推荐ESWL治疗;而对直径>1 cm的输尿管结石,尤其是中下段结石,建议首选输尿管镜钬激光碎石术。Abstract: Objective: To compare the safety and efficacy of ureteroscopy with holmium:YAG laser lithotripsy (LL) and extracorporeal shock-wave lithotripsy (ESWL) for ureteral calculi. Method:The data of 465 patients from January 2008 to September 2012 were analyzed. Ureteroscopy with holmium:YAG laser lithotripsies were taken in 196 patients including 104 cases with diameter of stones > 1.0 cm and 92 cases with diameter of stones ≤ 1.0 cm. ESWL were taken in 269 patients including 128 cases with diameter of stones > 1.0 cm and 141 cases with diameter of stones ≤ 1.0 cm. The operation time, stone-free rate and incidence rate of complications were compared between the two groups. Result:The mean operation time of LL group for stones > 1.0 cm and ≤ 1.0 cm were shorter than those with ESWL (both P<0.01).The stone-free rate after three months in patints with stones > l.0 cm was 93.3% for LL group. It was higher than 69.5% with ESWL (P<0.01). For calculi ≤ 1.0 cm, the stone-free rate with LL and ESWL were 91.3% and 89.4% respectively (P>0.05). The stone-free rate after three months were 92.0% and 92.6% in the proximal and middle-distal ureteral calculi respectively without significant difference (P>0.05) in LL group. While in ESWL group were 87.2% and 74.3% respectively (P<0.01). The complication rate was 4.6% in the group of LL, while in the ESWL group no complications occurred. Conclusion: All things taken into consideration, for calculi ≤ 1.0 cm in diameter especially for the proximal ureteral calculi, ESWL is worth recommending. For calculi > 1.0 cm in diameter especially for the middle-distal ureteral calculi, ureteroscopy with holmium:YAG laser lithotripsy is the best choice.Key words ureteral calculi; extracorporeal shock-wave lithotripsy; YAG laser lithotripsy; ureteroscopic lithotripsy
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