Case-control study of 24-hour urinary citrate excretion in patients with recurrent urinary calculi and analysis of stone composition
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摘要: 目的: 分析复发性泌尿系结石患者尿枸橼酸排泄量与结石成分及微观形态,探讨泌尿系结石形成与复发的防治措施。方法: 采用病例对照的研究方法,比较复发性泌尿系结石患者与对照组之间的尿枸橼酸排泄量,并运用红外光谱、X线衍射及扫描电镜分析复发性结石的成分与微观形态。结果: 复发性结石患者尿枸橼酸排泄量显著低于对照组。结石的成分以草酸钙(80%)和尿酸结石(33%)为主。结论: 结石患者术后的代谢分析、严格随访和适量的枸橼酸盐补充,可能在一定程度上降低泌尿系结石的复发率。泌尿系结石的成分分析可为制定预防结石复发方案提供理论依据。Abstract: Objective: To analyze 24-hour urinary citrate excretion and stone composition of recurrent urinary calculi patients. Method:The case-control study was conducted to compare 24-hour urinary citrate excretion between the recurrent urinary calculi patients and normal people who recovered from urinary calculi. Infrared spectroscopy, X-ray diffraction and scanning electron microscope were used for analyzing the micromorphology and composition of stones. Result:24-hour urinary citrate excretion in patients with recurrent urinary calculi was significantly lower than normal people who recovered from urinary calculi, and the main composition were calcium oxalate (80%) and uric acid (33%). Conclusion: Metabolism analysis, strict follow-up and appropriate supply of citrate may decrease the recurrence rate of urinary calculi. The result of composition of stones can be accepted as a theoretical base for preventive guidelines of urinary calculi.Key words recurrent urinary calculi; citrate; stone composition; case-control study
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Key words:
- recurrent urinary calculi /
- citrate /
- stone composition /
- case-control study
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