干细胞治疗女性压力性尿失禁的研究进展

汪成合; 陈忠

doi:10.13201/j.issn.1001-1420.2014.05.031

干细胞治疗女性压力性尿失禁的研究进展

汪成合,
陈忠^,

- 华中科技大学附属同济医院泌尿外科(武汉, 430030)

详细信息

通讯作者: 陈忠,E-mail:chenzhongtj@126.com

中图分类号: R694.54

收稿日期: 2013-06-29

Research progress of stem cell therapy in female stress urinary incontinence

WANG Chenghe,
CHEN Zhong^,

- Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

More Information

Corresponding author: CHEN Zhong, E-mail: chenzhongtj@126.com

Received Date: 29 June 2013

摘要

摘要: 压力性尿失禁(SUI)是成年女性常见的泌尿系统疾病,给患者生活、工作和社会活动带来极大的影响。目前悬吊带术治疗SUI较成熟,微创简便,疗效确切,但可能出现并发症或者疾病复发。尿道周围注射填充剂,如牛胶原蛋白,远期效果不理想。干细胞是近年来研究的热点,有学者已尝试用其治疗SUI,特别是在大鼠SUI模型中研究较多,经尿道周围注射干细胞,如骨髓来源干细胞,肌肉来源干细胞和脂肪来源干细胞等,其可分化为平滑肌细胞等,提高大鼠尿道括约肌单位的功能,并促进神经细胞再生;注射的干细胞还可旁分泌多种因子,促进尿道组织再生,多种机制共同作用恢复尿道生理性的尿流控制能力。该治疗方法在临床开展较少,但仅有的数据也表明,在超声引导下经尿道周围注射干细胞能明显提高SUI患者的预后,改善排尿状况。
- 干细胞 /
- 女性压力性尿失禁 /
- 括约肌单位 /
- 尿道周围注射
Abstract: Stress urinary incontinence (SUI) is a prevalent urologic problem that commonly affects women's life, daily work and social activities.Though some minimally invasive surgeries, such as Urethral slings, are effective for many cases of SUI, recurrence or complication may be inevitable.It is not satisfactory to inject bulking agent of bovine collagen periurethrally in the long term.Stem cell therapy is a research focus recently.Many researchers have applied stem cell therapy in animals especially rats suffered from SUI.It is demonstrated that stem cells (i.e., bone marrow-derived stem cells, muscle-derived stem cells, adipose-derived stem cells) that periurethrally injected into rat model of SUI could differentiate into smooth muscle cells, elevate function of urethral sphincter unit, and promote neural regeneration.The stem cells may also produce paracrine multiple factors so as to strengthen urethral tissues.Thus, the physiological function of urethral continence is improved by the above mechanisms.The method of stem cells for SUI aren't popular clinically, whereas the recent limited data indicate that micturition of SUI patients is improved significantly after transurethral ultrasound-guided periurethral injections of stem cells.In summary, as more investigations are conducted, stem cell therapy will surely carry hope for female SUI patients.
- stem cell /
- female stress urinary incontinence /
- sphincter unit /
- periurethral injection

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