-
摘要: 目的:探讨后肾腺瘤(MA) 的临床表现、影像学及病理学特征,深化对其诊断与治疗的认识。方法:回顾性分析2例MA患者的临床资料,结合相关文献复习探讨MA的临床表现、影像学特征、病理结果、鉴别诊断、手术方法及预后。结果:2例患者术前诊断为肾肿瘤,1例行肾根治性切除术,1例行保留肾单位手术(NSS) ,术后病理检查均为MA。例1随访12个月,例2随访3个月,均未出现复发及转移。结论:MA是一种罕见的肾脏上皮组织良性肿瘤,常误诊为肾癌,术前增强CT对诊断有帮助,最终诊断往往需要依靠术后病理检查。因MA的良性生物学行为,NSS为其理想的治疗选择,但术后需要密切随访。Abstract: Objective:To explore the clinical, radiological and histopathological features of metanephric adenoma (MA), and deepen the knowledge of its diagnosis and treatment.Method:We retrospectively analyzed the clinical data of two cases of MA including clinical feature, radiological characteristics, histopathological features, differential diagnosis, surgical procedure and prognosis and reviewed the relative literature.Result:The preoperative diagnosis of the two patients were tumor of kidney. One patient underwent radical nephrectomy and the other received nephron-sparing surgery (NSS). The postoperative pathologic report of the two patients were both MA. No tumor recurrence or distant metastasis was found over the follow-up period of 3-12 months.Conclusion:MA is a rare benign renal neoplasm, but it is often misdiagnosed as renal carcinoma. Although CT imaging may be useful in diagnosis, final confirmation relys on postoperative pathologic report. NSS is the preferred choice for MA because of its benign biological behavior. However, a close follow-up is required.
-
Key words:
- kidney neoplasm /
- metanephric adenoma /
- pathology /
- nephron-sparing surgery
-
-
[1] Amin M B, Amin M B, Tamboli P, et al. Prognostic impact of histologic subtyping of adult renal epithelial neoplasms: an experience of 405 cases[J]. Am J Surg Pathol, 2002, 26(3): 281-291.
[2] Snyder M E, Bach A, Kattan M W, et al. Incidence of benign lesions for clinically localized renal masses smaller than 7 cm in radiological diameter: influence of sex[J]. J Urol, 2006, 176(6 Pt 1): 2391-2395; discussion 2395-2396.
[3] Conzo G, Sciascia V, Palazzo A, et al. Radiofrequency-assisted partial nephrectomy for metanephric adenoma: a case report and literature review[J]. Surg Innov, 2013, 20(1): 55-58.
[4] Mostofi F K, Sesterhenn I A, Davis C J. Benign tumors of the kidney[M]//Smith P H, Pavone-Marcaluso M. Progress and Controversies in Oncological Urology II, EORTC Genitourinary Group Monograph 5. New York, NY: Liss, 1988: 329-344.
[5] Eble J N, Sauter G, Epstein J I, et al. World Health Organization classification of tumours: Pathology and genetics of tumours of the urinary system and male genital organs[M]. Lyon: IARC Press, 2004: 44-46.
[6] Kato H, Suzuki M, Aizawa S, et al. Metanephric adenoma of the kidney with massive hemorrhage and necrosis: immunohistochemical,ultrastructural, and flow cytometric studies[J]. Int J Surg Pathol, 2003, 11(4): 345-352.
[7] Bastide C, Rambeaud J J, Bach A M, et al. Metanephric adenoma of the kidney: clinical and radiological study of nine cases[J]. BJU Int, 2009, 103(11): 1544-1548.
[8] Zhu Q, Zhu W, Wu J, et al. The clinical and CT imaging features of metanephric adenoma[J]. Acta Radiol, 2014, 55(2): 231-238.
[9] 王聪, 宋国新, 李明娜, 等. 后肾腺瘤八例临床病理学特点[J]. 中华病理学杂志, 2014, 43(3): 154-157.
[10] 王翔, 赵彬李, 黎承杨, 等. 后肾腺瘤的病理特征(2例报告并文献复习)[J]. 现代泌尿生殖肿瘤杂志, 2013, 5(1): 12-15.
[11] Dadone B, Ambrosetti D, Carpentier X, et al. A renal metanephric adenoma showing both a 2p16e24 deletion and BRAF V600E mutation: a synergistic role for a tumor suppressor gene on chromosome 2p and BRAF activation[J]? Cancer Genet, 2013, 206(9-10): 347-352.
[12] Mantoan Padilha M, Billis A, Allende D, et al. Metanephric adenoma and solid variant of papillary renal cell carcinoma: common and distinctive features[J]. Histopathology, 2013, 62(6): 941-953.
[13] Bastide C, Rambeaud J J, Bach A M, et al. Metanephric adenoma of the kidney: clinical and radiological study of nine cases[J]. BJU Int, 2009, 103(11): 1544-1548.
[14] Torricelli F C, Marchini G S, Campos R S, et al. Metanephric Adenoma: clinical, imaging, and Histological findings[J]. Clinics (Sao Paulo), 2011, 66(2): 359-361.
[15] Kosugi M, Nagata H, Nakashima J, et al. A case of metanephric adenoma treated with partial nephrectomy[J]. Nihon Hinyokika Gakkai Zasshi, 2000, 91(4): 489-492.
[16] Ebine T, Ohara R, Momma T, et al. Metanephric adenoma treated with laparoscopic nephrectomy[J]. Int J Urol, 2004, 11(4): 232-234.
[17] Kumar S, Mandal A K, Acharya N R, et al. Laparoscopic nephron-sparing surgery for metanephric adenoma[J]. Surg Laparosc Endosc Percutan Tech, 2007, 17(6): 573-575.
[18] Bastide C, Rambeaud J J, Bach A M, et al. Metanephric adenoma of the kidney: clinical and radiological study of nine cases[J]. BJU Int, 2009, 103(11): 1544-1548.
[19] Conzo G, Sciascia V, Palazzo A, et al. Radiofrequency-assisted partial nephrectomy for metanephric adenoma: a case report and literature review[J]. Surg Innov, 2013, 20(1): 55-58.
[20] 刘东锋, 朱友志, 胡勇, 等. 后肾腺瘤的临床、病理及影像学诊断[J]. 实用放射学杂志, 2010, 26(3): 384-387.
[21] Renshaw A A, Freyer D R, Hammers Y A. Metastatic metanephric adenoma in a child[J]. Am J Surg Pathol, 2000, 24(4): 570-574.
[22] Picken M M, Curry J L, Lindgren V, et al. Metanephric adenosarcoma in a young adult: morphologic, immunophenotypic, ultrastructural, and fluorescence in situ hybridization analyses: a case report and review of the literature[J]. Am J Surg Pathol, 2001, 25(11): 1451-1457.
[23] 张晓光, 徐勇, 张淑敏, 等. 6例后肾腺瘤的临床与病理学特点分析[J]. 中国肿瘤临床, 2008, 35(17): 984-987.
[24] Drut R, Drut R M, Ortolani C. Metastatic metanephric adenoma with foci of papillary carcinoma in a child: a combined histologic, immunohistochemical, and FISH study[J]. Int J Surg Pathol, 2001, 9(3): 241-247.
-
计量
- 文章访问数: 137
- PDF下载数: 113
- 施引文献: 0