Clinicopathologic analysis of clear cell papillary renal cell carcinoma:our experience of five cases
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摘要: 目的:探讨透明细胞乳头状肾细胞癌的临床及病理特征、诊断、鉴别诊断,提高对该肾细胞癌亚型的了解。方法:收集2013年8月~2016年6月我院收治的5例透明细胞乳头状肾细胞癌患者的临床资料,重新对HE染色组织切片以及免疫组织化学切片进行光镜观察,并随访。结果:5例患者中男4例,女1例。平均年龄(61.6±15.3)(42.0~82.0)岁。平均肿瘤最大径为(3.3±1.0)(2.5~5.0)cm,除1例为pT1b期外均为pT1a期。5例患者免疫组织化学均表现为角蛋白7(CK7)、波形蛋白(Vimentin)阳性,CD10(4/5)、TFE-3(4/4)阴性。随访时间(11.4±14.9)(2.0~37.0)个月,未发现肿瘤淋巴结及远处转移,病情稳定。结论:透明细胞乳头状肾细胞癌是一种低度恶性肿瘤,目前尚未有淋巴结或远处转移的相关报道,形态上需与多种具有透明细胞和乳头状结构的肾癌鉴别,诊断这一肿瘤至少需要同时满足形态学和免疫组织化学的诊断条件。Abstract: Objective: To investigate the clinicopathologic features of clear cell papillary renal cell carcinoma (CCPRCC) so as to improve the understanding of this disease.Method: From August 2013 to June 2016, five patients with CCPRCC were included. The morphologic and immunohistochemical features were studied along with clinical and follow-up information retrospectively.Result: The patients included four men and one women whose mean age was (61.6±15.3) (range, 42.0-82.0) years old. Tumors were stage pT1a, except one pT1b, with a mean diameter of (3.3±1.0) (range, 2.5-5.0) cm. CK7 and Vimentin were both positive in all cases, while negative reactions occurred for CD10 (4/5) and TFE3 (4/4). During a mean follow-up period of (11.4±14.9) (range, 2.0-37.0) months, no patient developed local recurrence, distant metastasis or cancer death.Conclusion: CCPRCC is a typically small, biologically indolent tumor without recurrence or metastasis. More attention should be paid to its accurate classification and identification from other more aggressive RCC.
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