Multivariate study of factors affecting the results of prostate biopsy in PSA grey zone
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摘要: 目的：探讨灰区PSA（4~10μg/L）区间影响前列腺穿刺活检结果的因素。方法：回顾性分析2013年6月~2016年7月446例灰区PSA患者，应用12+X的方法进行超声引导下前列腺穿刺活检术。同时收集患者年龄、BMI、f/t比值、前列腺体积、PSAD、尿常规结果、DRE、超声造影以及MRI资料，运用SPSS 22.0进行统计分析。结果：总体穿刺阳性率为25.34%（113/446）；单因素回归分析显示：年龄（P=0.000）、tPSA（P=0.012）、f/t比值（P=0.000）、PSAD（P=0.000）、超声造影（P=0.000）以及MRI（P=0.000）与前列腺穿刺阳性率显著相关（P<0.05）；Logistic多因素回归分析显示：年龄（P=0.000）、BMI（P=0.038）、f/t比值（P=0.010）、PSAD（P=0.000）、DRE（P=0.023）、超声造影（P=0.000）以及MRI（P=0.046）与前列腺穿刺阳性率显著相关（P<0.05）；ROC面积前三位为PSAD，年龄和超声造影。结论：在灰区PSA前列腺穿刺活检中，年龄、PSAD、超声造影等是较好的预测因子。Abstract: Objective: To evaluate the factors affecting the results of prostate biopsy in PSA grey zone.Method: We retrospectively analyzed the 446 patients with PSA in grey zone from June 2013 to July 2016.The age, BMI, f/t, prostate volume, PSAD, urine analysis, DRE, contrast-enhanced ultrasound and MRI results were assessed with SPSS 22.0.Result: The total positive rate was 25.34%.Univariate analysis showed that age, tPSA, f/t, PSAD, contrast-enhanced ultrasound and MRI were significant factors, while multivariate analysis demonstrated that age, BMI, f/t, PSAD, DRE, contrast-enhanced ultrasound and MRI were significant factors.The first three ROC factors were PSAD, age and contrast-enhanced ultrasound.Conclusion: Age, PSAD and contrast-enhanced ultrasound are three best predictors in prostate biopsy in PSA grey zone.
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Key words:
- prostate cancer /
- prostate biopsy /
- multivariate study /
- grey zone PSA
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