花生四烯酸代谢产物与肿瘤发生和发展的研究进展

宋一萌; 李明真; 马潞林

doi:10.13201/j.issn.1001-1420.2017.03.019

花生四烯酸代谢产物与肿瘤发生和发展的研究进展

- 北京大学第三医院泌尿外科, （北京, 100083）

详细信息

通讯作者: 马潞林, E-mail:malulin@medmail.com.cn

中图分类号: R730.2

收稿日期: 2016-12-14

Research advances in the association between arachidonic acid metabolites and tumorigenesis

- Department of Urology, Peking University Third Hospital, Beijing, 100083, China

More Information

Corresponding author: MA Lulin, E-mail: malulin@medmail.com.cn

Received Date: 14 December 2016

摘要

摘要: 已有报道指出花生四烯酸代谢通路与多种癌症的发生发展密切相关。然而, 其中涉及的具体机制尚不明确。本文将对花生四烯酸的主要代谢产物在肿瘤细胞增殖和凋亡、肿瘤转移、肿瘤血管新生和炎症反应等方面进行综述。
- 肿瘤 /
- 花生四烯酸 /
- 前列腺素 /
- 环氧化二十碳三烯酸 /
- 羟基二十碳四烯酸
Abstract: It has been reported that arachidonic acid pathway was intimately associated with the development and progression of numerous cancer diseases.However, the precise roles they play remain unclear.This review is to give a brief introduction of the roles of arachidonic acid metabolites in cell proliferation and apoptosis, metastasis, angiogenesis and inflammation of tumors.
- tumor /
- arachidonic acid /
- prostaglandin /
- epoxyeicosatrienoic acid /
- hydroxyeicosatetraenoic acid

HTML全文

参考文献(29)

[1]	Lee J W, Park J H, Suh J H, et al.Cyclooxygenase-2expression and its prognostic significance in clear cell renal cell carcinoma[J].Korean J Pathol, 2012, 46 (3):237-245.
[2]	Ohba K, Miyata Y, Watanabe S, et al.Clinical significance and predictive value of prostaglandin E2 receptors (EPR) 1-4in patients with renal cell carcinoma[J].Anticancer Res, 2011, 31 (2):597-605.
[3]	Harris R E, Casto B C, Harris Z M.Cyclooxygenase-2and the inflammogenesis of breast cancer[J].World JClin Oncol, 2014, 5 (4):677-692.
[4]	Banno K, Iida M, Yanokura M, et al.Drug repositioning for gynecologic tumors:a new therapeutic strategy for cancer[J].Scientific World Journal, 2015, 2015:341362.
[5]	Lalier L, Pedelaborde F, Braud C, et al.Increase in intracellular PGE2 induces apoptosis in Bax-expressing colon cancer cell[J].BMC Cancer, 2011, 11:153.
[6]	Yang S, Gao Q, Jiang W.Relationship between tumour angiogenesis and expression of cyclo-oxygenase-2and vascular endothelial growth factor-A in human renal cell carcinoma[J].J Int Med Res, 2015, 43 (1):110-117.
[7]	Nakanishi M, Rosenberg D W.Multifaceted roles of PGE2 in inflammation and cancer[J].Semin Immunopathol, 2013, 35 (2):123-137.
[8]	Finetti F, Terzuoli E, Bocci E, et al.Pharmacological inhibition of microsomal prostaglandin E synthase-1suppresses epidermal growth factor receptor-mediated tumor growth and angiogenesis[J].PLoS One, 2012, 7 (7):e40576.
[9]	Tacconelli S, Patrignani P.Inside epoxyeicosatrienoic acids and cardiovascular disease[J].Front Pharmacol, 2014, 5:239.
[10]	Chen C, Wei X, Rao X, et al.Cytochrome P450 2 J2is highly expressed in hematologic malignant diseases and promotes tumor cell growth[J].J Pharmacol Exp Ther, 2011, 336 (2):344-355.
[11]	Schmelzle M, Dizdar L, Matthaei H, et al.Esophageal cancer proliferation is mediated by cytochrome P450 2 C9 (CYP2C9) [J].Prostaglandins Other Lipid Mediat, 2011, 94 (1-2):25-33.
[12]	Wei X, Zhang D, Dou X, et al.Elevated 14, 15-epoxyeicosatrienoic acid by increasing of cytochrome P450 2 C8, 2 C9 and 2 J2 and decreasing of soluble epoxide hydrolase associated with aggressiveness of human breast cancer[J].BMC Cancer, 2014, 14:841.
[13]	Panigrahy D, Kaipainen A, Greene E R, et al.Cytochrome P450-derived eicosanoids:the neglected pathway in cancer[J].Cancer Metastasis Rev, 2010, 29 (4):723-735.
[14]	Imig J D.Epoxides and soluble epoxide hydrolase in cardiovascular physiology[J].Physiol Rev, 2012, 92 (1):101-130.
[15]	Liu L, Chen C, Gong W, et al.Epoxyeicosatrienoic acids attenuate reactive oxygen species level, mitochondrial dysfunction, caspase activation, and apoptosis in carcinoma cells treated with arsenic trioxide[J].J Pharmacol Exp Ther, 2011, 339 (2):451-463.
[16]	Khan M A, Liu J, Kumar G, et al.Novel orally active epoxyeicosatrienoic acid (EET) analogs attenuate cisplatin nephrotoxicity[J].FASEB J, 2013, 27 (8):2946-2956.
[17]	Panigrahy D, Greene E R, Pozzi A, et al.EET signaling in cancer[J].Cancer Metastasis Rev, 2011, 30 (3-4):525-540.
[18]	Xu X, Zhang X A, Wang D W.The roles of CYP450 epoxygenases and metabolites, epoxyeicosatrienoic acids, in cardiovascular and malignant diseases[J].Adv Drug Deliv Rev, 2011, 63 (8):597-609.
[19]	Thomson S J, Askari A, Bishop-Bailey D.Anti-inflammatory effects of epoxyeicosatrienoic acids[J].Int JVasc Med, 2012, 2012:605101.
[20]	Nithipatikom K, Brody D M, Tang A T, et al.Inhibition of carcinoma cell motility by epoxyeicosatrienoic acid (EET) antagonists[J].Cancer Sci, 2010, 101 (12):2629-2636.
[21]	Xu X M, Yuan G J, Deng J J, et al.Inhibition of 12-lipoxygenase reduces proliferation and induces apoptosis of hepatocellular carcinoma cells in vitro and in vivo[J].Hepatobiliary Pancreat Dis Int, 2012, 11 (2):193-202.
[22]	Gohara A, Eltaki N, Sabry D, et al.Human 5-, 12-and 15-lipoxygenase-1coexist in kidney but show opposite trends and their balance changes in cancer[J].Oncol Rep, 2012, 28 (4):1275-1282.
[23]	Chen L, Ackerman R, Saleh M, et al.20-HETE regulates the angiogenic functions of human endothelial progenitor cells and contributes to angiogenesis in vivo[J].J Pharmacol Exp Ther, 2014, 348 (3):442-451.
[24]	Alexanian A, Sorokin A.Targeting 20-HETE producing enzymes in cancer-rationale, pharmacology, and clinical potential[J].Onco Targets Ther, 2013, 6:243-255.
[25]	Viola K, Kopf S, Huttary N, et al.Bay11-7082inhibits the disintegration of the lymphendothelial barrier triggered by MCF-7 breast cancer spheroids;the role of ICAM-1and adhesion[J].Br J Cancer, 2013, 108 (3):564-569.
[26]	Tang K, Cai Y, Joshi S, et al.Convergence of eicosanoid and integrin biology:12-lipoxygenase seeks a partner[J].Mol Cancer, 2015, 14:111.
[27]	Guo A M, Janic B, Sheng J, et al.The cytochrome P4504 A/F-20-hydroxyeicosatetraenoic acid system:a regulator of endothelial precursor cells derived from human umbilical cord blood[J].J Pharmacol Exp Ther, 2011, 338 (2):421-429.
[28]	Singh H, Cheng J, Deng H, et al.Vascular cytochrome P450 4 A expression and 20-hydroxyeicosatetraenoic acid synthesis contribute to endothelial dysfunction in androgen-induced hypertension[J].Hypertension, 2007, 50 (1):123-129.
[29]	Vanella L, Di Giacomo C, Acquaviva R, et al.Effects of ellagic Acid on angiogenic factors in prostate cancer cells[J].Cancers (Basel), 2013, 5 (2):726-738.