间质性膀胱炎的治疗策略

庞阳阳, 龚玉雯, 刘伟, 等. 间质性膀胱炎的治疗策略[J]. 临床泌尿外科杂志, 2017, 32(5): 400-404. doi: 10.13201/j.issn.1001-1420.2017.05.019
引用本文: 庞阳阳, 龚玉雯, 刘伟, 等. 间质性膀胱炎的治疗策略[J]. 临床泌尿外科杂志, 2017, 32(5): 400-404. doi: 10.13201/j.issn.1001-1420.2017.05.019
PANG Yangyang, GONG Yuwen, LIU Wei, et al. Treatment strategies for interstitial cystitis[J]. J Clin Urol, 2017, 32(5): 400-404. doi: 10.13201/j.issn.1001-1420.2017.05.019
Citation: PANG Yangyang, GONG Yuwen, LIU Wei, et al. Treatment strategies for interstitial cystitis[J]. J Clin Urol, 2017, 32(5): 400-404. doi: 10.13201/j.issn.1001-1420.2017.05.019

间质性膀胱炎的治疗策略

详细信息
    通讯作者: 王志平,E-mail:erywzp@lzu.edu.cn
  • 中图分类号: R694

Treatment strategies for interstitial cystitis

More Information
  • 间质性膀胱炎是一种不明病因的慢性异质性疾病,使很大一部分女性受累。患者的症状高度可变:可能会遭受骨盆疼痛而且疼痛会由于膀胱的充盈而加剧,并且会伴随有一系列的下尿路症状,包括尿频和尿急。考虑到不同患者临床表现并不完全相同,因此应该针对每个具体的患者给予相应的治疗。目前美国泌尿协会(AUA)指南将IC治疗分为6个层次,建议开始对患者进行教育以及改善生活方式,再通过物理、药物治疗,对于那些前期治疗均失败的患者最终进行手术治疗。这篇文章针对IC最新治疗指南以及这些指南的一些证据资料进行了综述。
  • 加载中
  • [1]

    Berry S H,Elliott M N,Suttorp M,et al.Prevalence of symptoms of bladder pain syndrome/interstitial cystitis among adult females in the United States[J].J Urol,2011,186(2):540-544.

    [2]

    Hanno P M,Burks D A,Clemens J Q,et al.AUAguideline for the diagnosis and treatment of interstitial cystitis/bladder pain syndrome[J].J Urol,2011,185(6):2162-2170.

    [3]

    Hanno P M,Erickson D,Moldwin R,et al.Diagnosis and treatment of interstitial cystitis/bladder pain syndrome:AUA guideline amendment[J].J Urol,2015,193(5):1545-1553.

    [4]

    Fitzgerald M P,Payne C K,Lukacz E S,et al.Randomized multicenter clinical trial of myofascial physical therapy in women with interstitial cystitis/painful bladder syndrome and pelvic floor tenderness[J].J Urol,2012,187(6):2113-2118.

    [5]

    van Ophoven A,Pokupic S,Heinecke A,et al.A prospective,randomized,placebo controlled,double-blind study of amitriptyline for the treatment of interstitial cystitis[J].J Urol,2004,172(2):533-536.

    [6]

    van Ophoven A,Hertle L.Long-term results ofamitriptyline treatment for interstitial cystitis[J].J Urol,2005,174(5):1837-1840.

    [7]

    Barr S.Diagnosis and management of interstitial cystitis[J].Obstet Gynecol Clin North Am,2014,41(3):397-407.

    [8]

    Thilagarajah R,Witherow R O,Walker M M.Oral cimetidine gives effective symptom relief in painful bladder disease:aprospective,randomized,double-blind placebo-controlled trial[J].BJU Int,2001,87(3):207-212.

    [9]

    Sant G R,Propert K J,Hanno P M,et al.A pilot clinical trial of oral pentosan polysulfate and oral hydroxyzine in patients with interstitial cystitis[J].JUrol,2003,170(3):810-815.

    [10]

    Janssen D A,van Wijk X M,Jansen K C,et al.The distribution and function of chondroitin sulfate and other sulfated glycosaminoglycans in the human bladder and their contribution to the protective bladder barrier[J].JUrol,2013,189(1):336-342.

    [11]

    Nickel J C,Herschorn S,Whitmore K E,et al.Pentosan polysulfate sodium for treatment of interstitial cystitis/bladder pain syndrome:insights from a randomized,double-blind,placebo controlled study[J].JUrol,2015,193(3):857-862.

    [12]

    Sairanen J,Tammela T L,Leppilahti M,et al.Cyclosporine A and pentosan polysulfate sodium for the treatment of interstitial cystitis:a randomized comparative study[J].J Urol,2005,174(6):2235-2238.

    [13]

    Sairanen J,Forsell T,Ruutu M.Long-term outcome of patients with interstitial cystitis treated with low dose cyclosporine A[J].J Urol,2004,171(6 Pt 1):2138-2141.

    [14]

    Ehren I,Hallen G K,Vrba M,et al.Nitric oxide as a marker for evaluation of treatment effect of cyclosporine A in patients with bladder pain syndrome/interstitial cystitis type 3C[J].Scand J Urol,2013,47(6):503-508.

    [15]

    Colaco M A,Evans R J.Current recommendations for bladder instillation therapy in the treatment of interstitial cystitis/bladder pain syndrome[J].Curr Urol Rep,2013,14(5):442-447.

    [16]

    Moldwin R M,Evans R J,Stanford E J,et al.Rational approaches to the treatment of patients with interstitial cystitis[J].Urology,2007,69(4 Suppl):73-81.

    [17]

    Stav K,Beberashvili I,Lindner A,et al.Predictors of response to intravesical dimethyl-sulfoxide cocktail in patients with interstitial cystitis[J].Urology,2012,80(1):61-65.

    [18]

    Slobodov G,Feloney M,Gran C,et al.Abnormal expression of molecular markers for bladder impermeability and differentiation in the urothelium of patients with interstitial cystitis[J].J Urol,2004,171(4):1554-1558.

    [19]

    Kyker K D,Coffman J,Hurst R E.Exogenous glycosaminoglycans coat damaged bladder surfaces in experimentally damaged mouse bladder[J].BMC Urol,2005,5:4.

    [20]

    Campbell N A,Reece J B.Campbell biology[M].9th ed.ed.Boston:Benjamin Cummings/Pearson,2011.1263.

    [21]

    Nickel J C,Moldwin R,Lee S,et al.Intravesical alkalinized lidocaine(PSD597)offers sustained relief from symptoms of interstitial cystitis and painful bladder syndrome[J].BJU Int,2009,103(7):910-918.

    [22]

    Nickel J C,Jain P,Shore N,et al.Continuous intravesical lidocaine treatment for interstitial cystitis/bladder pain syndrome:safety and efficacy of a new drug delivery device[J].Sci Transl Med,2012,4(143):100r-143r.

    [23]

    Niimi A,Nomiya A,Yamada Y,et al.Hydrodistension with or without fulguration of hunner lesions forinterstitial cystitis:Long-term outcomes and prognostic predictors[J].Neurourol Urodyn,2016,35(8):965-969.

    [24]

    Hsieh C H,Chang W C,Huang M C,et al.Hydrodistention plus bladder training versus hydrodistention for the treatment of interstitial cystitis[J].Taiwan J Obstet Gynecol,2012,51(4):591-595.

    [25]

    Aihara K,Hirayama A,Tanaka N,et al.Hydrodistension under local anesthesia for patients with suspected painful bladder syndrome/interstitial cystitis:safety,diagnostic potential and therapeutic efficacy[J].Int JUrol,2009,16(12):947-952.

    [26]

    Payne R A,O'Connor R C,Kressin M,et al.Endoscopic ablation of Hunner's lesions in interstitial cystitis patients[J].Can Urol Assoc J,2009,3(6):473-477.

    [27]

    Hillelsohn J H,Rais-Bahrami S,Friedlander J I,et al.Fulguration for Hunner ulcers:long-term clinical outcomes[J].J Urol,2012,188(6):2238-2241.

    [28]

    Smith C P,Radziszewski P,Borkowski A,et al.Botulinum toxin a has antinociceptive effects in treating interstitial cystitis[J].Urology,2004,64(5):871-875.

    [29]

    Kuo H C.Preliminary results of suburothelialinjection of botulinum a toxin in the treatment of chronic interstitial cystitis[J].Urol Int,2005,75(2):170-174.

    [30]

    Giannantoni A,Costantini E,Di Stasi S M,et al.Botulinum A toxin intravesical injections in the treatment of painful bladder syndrome:apilot study[J].Eur Urol,2006,49(4):704-709.

    [31]

    Ramsay A K,Small D R,Conn I G.Intravesical botulinum toxin type A in chronic interstitial cystitis:results of a pilot study[J].Surgeon,2007,5(6):331-333.

    [32]

    Liu H T,Tyagi P,Chancellor M B,et al.Urinary nerve growth factor level is increased in patients with interstitial cystitis/bladder pain syndrome and decreased in responders to treatment[J].BJU Int,2009,104(10):1476-1481.

    [33]

    Kuo H C,Chancellor M B.Comparison of intravesical botulinum toxin type A injections plus hydrodistention with hydrodistention alone for the treatment of refractory interstitial cystitis/painful bladder syndrome[J].BJU Int,2009,104(5):657-661.

  • 加载中
计量
  • 文章访问数:  282
  • PDF下载数:  281
  • 施引文献:  0
出版历程
收稿日期:  2016-12-31

目录