Relationships between the protein expression of AR and IGF-1R and risk factors in prostate cancer
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摘要: 目的：探讨前列腺癌组织中雄激素受体（AR）、胰岛素样生长因子1受体（IGF-1R）的蛋白表达并与前列腺癌危险因素进行比较分析。方法：42例前列腺癌根据临床分期、Gleason评分、血清PSA浓度分为中低危组、高危组，采用免疫组织化学方法检测前列腺癌组织中AR及IGF-1R的蛋白表达阳性率，分析这两种蛋白表达阳性率在中低危组、高危组之间的差异。结果：临床分期中低危组、高危组AR表达阳性率分别为57%、66%，两组比较差异无统计学意义（P>0.05）；IGF-1R表达阳性率分别为24%、37%，两组比较差异有统计学意义（P<0.05）。Gleason评分中低危组、高危组AR表达阳性率分别为46%、57%，两组比较差异有统计学意义（P<0.05）；IGF-1R表达阳性率分别为26%、34%，两组比较差异无统计学意义（P>0.05）。血清PSA浓度中低危组、高危组AR表达阳性率分别为46%、54%，IGF-1R表达阳性率分别为28%、31%，两组比较差异均无统计学意义（P>0.05）。结论：前列腺癌组织中AR蛋白表达在高危Gleason评分时增加，IGF-1R蛋白表达在高危临床分期时增加。
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关键词:
- 前列腺癌 /
- 雄激素受体 /
- 胰岛素样生长因子1受体 /
- 危险因素
Abstract: Objective: To explore androgen receptor (AR) and insulin like growth factor-1receptor (IGF-1R) protein expression and analyze the relationships between the protein expression and the risk factors in prostate cancer (PCa).Method: Forty-two cases of PCa were divided into low-middle and high risk factor groups based on clinical stage, serum prostatic specific antigen (PSA) concentration and Gleason score.The percentages of PCa cells that expressed AR or IGF-1R protein in paraffin bedded PCa tissue were measured by immunohistochemistry, and the difference of AR and IGF-1R positive expressing cells between the low-middle and high risk factor groups were determined.Result: With respect to clinical stage, the percentages of AR expression cells were 57% and 66% respectively (P>0.05), and the percentages of IGF-1R expressing cells were 24% and 37%respectively (P<0.05) between the low-middle and the high risk factor groups.With respect to Gleason score, the percentages of AR expressing cells were 46% and 57% respectively (P<0.05), and the percentages of IGF-1R expressing cells were 26% and 34% respectively (P>0.05) between the low-middle and high risk factor groups.With respect to PSA concentration, the percentages of AR expressing cells were 46% and 54% respectively (P<0.05), and the percentages of IGF-1R expressing cells were 28% and 31%respectively (P>0.05) between the low-middle and the high risk factor groups.Conclusion: The expression of AR protein increased in the PCa tissue of high risk Gleason score, and the expression of IGF-1R protein increased in the PCa tissue of high risk clinical stage.-
Key words:
- prostate cancer /
- androgen receptor /
- insulin like growth factor-1receptor /
- risk factor
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