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摘要: 目的:分析颈动脉内膜中层厚度(C-IMT)与国际勃起功能指数-5(IIEF-5)评分、血管内皮功能(FMD)间的相关性。方法:分析2017年2月~2018年3月来我中心行C-IMT检查的362例男性健康体检数据。按C-IMT测量值1.0mm为分割点,分为C-IMT<1.0mm组(n=92)和C-IMT≥1.0mm组(n=270)。比较两组受试者年龄、BMI、吸烟率、饮酒比例、血压、甘油三酯、总胆固醇、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、血肌酐、尿酸、空腹血糖,并分析C-IMT、IIEF-5、FMD值间的相关性。结果:两组年龄、BMI、血压、血肌酐、血尿酸、血胆固醇、血糖、甘油三脂、HDL、LDL比较差异无统计学意义(P>0.05),但C-IMT≥1.0mm组受试者的吸烟率及饮酒比例均高于C-IMT<1.0mm组(P<0.05)。Pearson相关性分析显示,C-IMT与IIEF-5呈负相关(r=-0.477,P<0.001),C-IMT与FMD值呈负相关(r=-0.466,P<0.001),FMD值与IIEF-5呈正相关(r=0.549,P<0.001)。结论:通过本研究发现C-IMT与男性勃起功能及血管内皮功能均呈负相关,但C-IMT是否能预测男性的勃起功能及血管内皮功能仍需进一步研究证实。Abstract: Objective:To investigate the relationship between carotid intima-media thickness (C-IMT) and male erectile function (IIEF-5), vascular endothelial function (FMD).Method:From February, 2017 to March, 2018, 362 healthy males who received the C-IMT in our centre were enrolled in this study.These patients were divided into two groups based on the C-IMT value (C-IMT<1.0 mm and C-IMT ≥ 1.0 mm group).Their age, BMI, blood pressure, serum creatinine, uric acid, cholesterol, blood glucose, triglyceride, low density lipoprotein, high density lipoprotein were compared between two groups.Moreover, the relationship among C-IMT, IIEF-5, FMD value were analyzed by correlation Pearson analyzation.Result:There was no statistic difference in their age, BMI, blood pressure, serum creatinine, uric acid, cholesterol, blood glucose, triglyceride, low density lipoprotein, high density lipoprotein between C-IMT<1.0 mm and C-IMT ≥ 1.0 mm group (P>0.05).However, there were more men who smoked and drank in the C-IMT ≥ 1.0 mm group (P<0.05).By the Pearson correlation analyzation, C-IMT was negatively related to the IIEF-5 and FMD value (r=-0.477, -0.466, respectively, P<0.001).Moreover, IIEF-5 was positively related to the FMD value (r=0.549, P<0.001).Conclusion:C-IMT was negatively related to the male erectile function and vascular endothelial function.But whether C-IMT could act as a predictor for male erectile function and vascular endothelial function needs further studies.
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[1] Montorsi F, Briganti A, Salonia A, et al.Erectile dysfunction prevalence, time of onset and association with risk factors in 300consecutive patients with acute chest pain and angiographically documented coronary artery disease[J].Eur Urol, 2003, 44 (3):360-364.
[2] 中国医师协会超声医师分会.血管超声检查指南[J].中华超声影像学杂志, 2009, 10 (18):911-920.
[3] Musicki B, Bella A J, Bivalacqua T J, et al.Basic Science Evidence for the Link Between Erectile Dysfunction and Cardiometabolic Dysfunction[J].J Sex Med, 2015, 12 (12):2233-2255.
[4] Reriani M, Flammer A J, Li J, et al.Microvascular endothelial dysfunction predicts the development of erectile dysfunction in men with coronary atherosclerosis without critical stenoses[J].Coron Artery Dis, 2014, 25 (7):552-557.
[5] Apostolovic S, Stanojevic D, Jankovic-Tomasevic R, et al.Erectile dysfunction as a predictor of two-year prognosis inacute myocardial infarction[J].Cardiol J, 2017, 24 (4):393-402.
[6] Skeldon S C, Cheng L, Morgan S G, et al.Erectile Dysfunction Medications and Treatment for Cardiometabolic Risk Factors:A Pharmacoepidemiologic Study[J].J Sex Med, 2017, 4 (12):1597-1605.
[7] Omland T, Randby A, Hrubos-Strøm H, et al.Relation of Erectile Dysfunction to Subclinical Myocardial Injury[J].Am J Cardiol, 2016, 118 (12):1821-1825.
[8] Feldman H A, Goldstein I, Hatzichristou D G, et al.Impotence and its medical and psychosocial correlates:results of the Massachusetts Male Aging Study[J].J Urol, 1994, 151 (1):54-61.
[9] Guay A T.ED2:erectile dysfunction=endothelial dysfunction[J].Endocrinol Metab Clin North Am, 2007, 36 (2):453-463.
[10] Wenning C, Kloth C, Kuhlmann M T, et al.Serial F-18-FDGPET/CT distinguishes inflamed from stable plaque phenotypesin shear-stress induced murine atherosclerosis[J].Atherosclerosis, 2014, 234 (2):276-282.
[11] Guaricci A I, Arcadi T, Brunetti N D, et al.Carotid intima media thickness and coronary atherosclerosis linkage in symptomatic intermediate risk patients evaluated by coronary computed tomography angiography[J].Int J Cardiol, 2014, 176 (3):988-993.
[12] Dogan S, Duivenvoorden R, Grobbee D E, et al.Ultrasound protocols to measure carotidintima-media thickness in trials:comparison of reproducibility rate of progression and effect of intervention in subjects with familial hypercholesterolemia and subjects with mixed dyslipidemia[J].Ann Med, 2010, 42 (6):447-464.
[13] 王玉, 张磊, 苑秀芳, 等.同型半胱氨酸与颈动脉内膜中层厚度[J].中国医学前沿杂志:电子版, 2011, 3 (3):23-27.
[14] Poredos P, Jezovnik M K.Testing endothelial function and its clinical relevance[J].J Atheroscler Thromb, 2013, 20 (1):1-8.
[15] Deanfield J E, Halcox J P, Rabelink T J.Endothelial function and dysfunction:testing and clinical relevance[J].Circulation, 2007, 115 (10):1285-1295.
[16] Brevetti G, Silvestro A, Schiano V, et al.Endothelial dysfunction and cardiovascular risk prediction in peripheral arterial disease:additive value of flow-mediated dilation to ankle-brachial pressure index[J].Circulation, 2003, 108 (17):2093-2098.
[17] 刘继红, 王涛, 康皓.腹壁下动脉-阴茎背深静脉吻合术治疗血管性勃起功能障碍的5例报告[J].临床泌尿外科杂志, 2017, 32 (6):454-457.
[18] Billups K L.Erectile dysfunction as a marker for vascular disease[J].Curr Urol Rep, 2005, 6 (6):439-444.
[19] Huang Y, Sun X, Liu G, et al.Glycosylated serum protein mayimprove our ability to predict endothelial and erectile dysfunction in nonorganic patients[J].J Sex Med, 2011, 8 (3):840-850.
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