Abstract: Objective: To evaluate the safety and efficacy of transurethral plasma needle electrode combined with coagulation electrode for bladder tumor resection. Method: The clinical data of 45 patients with bladder cancer admitted in our hospital from June 2016 to December 2017 were retrospectively analyzed. There were 37 males and 8 females. They were 30-80 years old, with an average age of (58 ±13) years old. The diameter of tumor ranged from 1 to 3 cm, with an average of (2.2 ±1.4) cm. There were 36 cases of solitary tumor and 9 cases of multiple tumors, of which 2 lumps were found in 6 cases and 3 lumps were found in 3 cases. There were 19 cases of lateral wall of bladder, 16 cases of posterior wall, and 10 cases of other parts. Preoperative pathological diagnosis was bladder urothelial carcinoma. Preoperative CTU showed no infiltration outside the bladder wall, and no tumor was found in the upper urinary tract. Transurethral plasma needle electrode plus coagulation electrode for bladder tumor resection under epidural spinal anesthesia was performed in 45 cases. During the operation, transurethral resection of bladder tumor was performed with needle electrode (hook electrode). Coagulating electrode was used to coagulate the wound. Specimens were sent to pathology. Result: Forty-five cases were successfully performed. Fifty-seven tumors were removed and the size of tumors ranged from 0.5 to 3 cm. The operation time ranged from 15 to 53 min, with an average of (30±19) min, and the intraoperative blood loss ranged from 1 to 10 ml, with an average of (5±3) ml. Obturator nerve reflex occurred only in 1 case. No perforation or postoperative bleeding was found. All patients were treated with intravesical instillation of chemotherapy with gemcitabine 50 mg immediately or after 24 h without obvious adverse reactions. Postoperative pathological diagnosis was non-muscle invasive bladder cancer (NMIBC). The margins were negative. Pathological stage classification showed 52 T₁G₁ urothelial carcinomas, 3 T₁G₂urothelial carcinomas, and 2 T₁G₃urothelial carcinomas. The cystoscope showed all the wounds healed well after 3 months. All 45 cases were followed up for 6-24 months, averaging (6.1±5.3) months. No tumor recurrence occurred.Conclusion: Transurethral plasma needle electrode plus coagulation electrode for bladder tumor resection layer by layer in the treatment of NMIBC shows advantages of clear anatomy, effective reduction of obturator nerve reflex, less bleeding, no perforation, intact specimens, accurate pathological stages, quick recovery and satisfactory clinical effects.