Application of frozen section analysis of ureteral resection margin in radical cystectomy
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摘要: 肿瘤上尿路复发是根治性膀胱切除术的术后晚期并发症之一。术中冰冻切片分析(FSA)长期以来用于识别输尿管切缘是否存在肿瘤侵犯,并指导术中进行适当的远端输尿管切除,降低术后上尿路复发的风险,但术中输尿管切缘FSA的应用具有较大的争议。本文结合相关研究结果,分析了输尿管切缘FSA的主要争议和应用价值。Abstract: Recurrence of the upper urinary tract is one of the late postoperative complications of radical cystectomy.Intraoperative frozen section analysis has long been used to identify the presence of tumor invasion in the ureteral resection margin and guide the intraoperative appropriate ureterectomy to reduce the risk of postoperative upper urinary tract recurrence.However, the application of intraoperative frozen section analysis of ureteral resection margin is controversial.In this paper, the main controversy and application value of frozen section analysis of ureteral resection margin were analyzed.
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[1] Gakis G, Efstathiou J, Lerner S P, et al.ICUD-EAUInternational Consultation on Bladder Cancer 2012:radical cystectomy and bladder preservation for muscle-invasive urothelial carcinoma of the bladder[J].Eur Urol, 2013, 63 (1):45-57.
[2] Alfred W J, Lebret T, Compérat E M, et al.Updated 2016 EAU Guidelines on Muscle-invasive and Metastatic Bladder Cancer[J].Eur Urol, 2017, 71 (3):462-475.
[3] Linder B J, Boorjian S A, Hudolin T, et al.Late Recurrence after Radical Cystectomy:Patterns, Risk Factors and Outcomes[J].J Urol, 2014, 191 (5):1256-1261.
[4] Picozzi S, Ricci C, Gaeta M, et al.Upper urinary tract recurrence following radical cystectomy for bladder cancer:a meta-analysis on 13, 185patients[J].J Urol, 2012, 188 (6):2046-2054.
[5] Furukawa J, Miyake H, Hara I, et al.Upper urinary tract recurrence following radical cystectomy for bladder cancer[J].Int J Urol, 2007, 14 (6):496-499.
[6] Takayanagi A, Masumori N, Takahashi A, et al.Upper urinary tract recurrence after radical cystectomy for bladder cancer:Incidence and risk factors[J].Int J Urol, 2012, 19 (3):229-233.
[7] Volkmer B G, Schnoeller T, Kuefer R, et al.Upper Urinary Tract Recurrence After Radical Cystectomy for Bladder Cancer-Who is at Risk?[J].J Urol, 2009, 182 (6):2632-2637.
[8] Gakis G, Schilling D, Perner S, et al.Sequential resection of malignant ureteral margins at radical cystectomy:a critical assessment of the value of frozen section analysis[J].World J Urol, 2011, 29 (4):451-456.
[9] Umbreit E C, Crispen P L, Shimko M S, et al.Multifactorial, site-specific recurrence model after radical cystectomy for urothelial carcinoma[J].Cancer, 2010, 116 (14):3399-3407.
[10] Tollefson M K, Blute M L, Farmer S A, et al.Significance of Distal Ureteral Margin at Radical Cystectomy for Urothelial Carcinoma[J].J Urol, 2010, 183 (1):81-86.
[11] Loeser A, Katzenberger T, Vergho D C, et al.Frozen section analysis of ureteral margins in patients undergoing radical cystectomy for bladder cancer:differential impact of carcinoma in situ in the bladder on reliability and impact on tumour recurrence in the upper urinary tract[J].Urol Int, 2014, 92 (1):50-54.
[12] Osman Y, El-Tabey N, Abdel-Latif M, et al.The value of frozen-section analysis of ureteric margins on surgical decision-making in patients undergoing radical cystectomy for bladder cancer[J].BJU Int, 2007, 99 (1):81-84.
[13] Satkunasivam R, Hu B, Metcalfe C, et al.The Utility and Significance of Ureteral Frozen Section Analysis During Radical Cystectomy[J].BJU Int, 2016, 117 (3):463-468.
[14] Satkunasivam R, Hu B, Daneshmand S.Is Frozen Section Analysis of Ureteral Margins at Time of Radical Cystectomy Useful?[J].Curr Urol Rep, 2015, 16 (6):38-38.
[15] Massonlecomte A, Francois T, Vordos D, et al.Predictive factors for final pathologic ureteral sections on 700radical cystectomy specimens:Implications for intraoperative frozen section decision-making[J].Urol Oncol, 2017, 35 (11):659.e1-659.e6.
[16] Hakozaki K, Kikuchi E, Fukumoto K, et al.Significance of a frozen section analysis of the ureteral margin in bladder cancer patients treated with radical cystectomy and neoadjuvant chemotherapy[J].Med Oncol, 2017, 34 (12):187-187.
[17] Kim H S, Moon K C, Jeong C W, et al.The clinical significance of intra-operative ureteral frozen section analysis at radical cystectomy for urothelial carcinoma of the bladder[J].World J Urol, 2015, 33 (3):359-365.
[18] Hoang A N, Agarwal P K, Walton-Diaz A, et al.Clinical significance of ureteric ‘skip lesions’ at the time of radical cystectomy:The M.D.Anderson experience and literature review[J].BJU Int, 2014, 113 (5b):E28-E33.
[19] Moschini M, Gallina A, Freschi M, et al.Effect on postoperative survival of the status of distal ureteral margin:The necessity to achieve negative margins at the time of radical cystectomy[J].Urol Oncol, 2016, 34 (2):59.e15-59.e22.
[20] Touma N, Izawa J I, Abdelhady M, et al.Ureteral frozen sections at the time of radical cystectomy:reliability and clinical implications[J].Can Urol Assoc J, 2010, 4 (1):28-32.
[21] Jalón-Monzón A, González-Ruiz dLC, Alvarez-Múgica M, et al.Usefulness of cold ureteral biopsy during radical cystectomy as a predictor of recurrence risk:Review of our series[J].Arch Esp Urol, 2018, 71 (5):486-494.
[22] Reder N P, Maxwell S P, Pambuccian S E, et al.Diagnostic accuracy of intraoperative frozen sections during radical cystectomy does not affect disease-free or overall survival:a study of 364patients with urothelial carcinoma of the urinary bladder[J].Ann Diagn Pathol, 2015, 19 (3):107-112.
[23] Hafner C, Knuechel R, Stoehr R, et al.Clonality of multifocal urothelial carcinomas:10years of molecular genetic studies[J].Int J Cancer, 2002, 101 (1):1-6.
[24] Gordetsky J, Bivalacqua T, Schoenberg M, et al.Ureteral and urethral frozen sections during radical cystectomy or cystoprostatectomy:an analysis of denudation and atypia[J].Urology, 2014, 84 (3):619-623.
[25] Neuzillet Y, Soulie M, Larre S, et al.Positive surgical margins and their locations in specimens are adverse prognosis features after radical cystectomy in non-metastatic carcinoma invading bladder muscle:results from a nationwide case-control study[J].BJU Int, 2013, 111 (8):1253-1260.
[26] Xylinas E, Rink M, Novara G, et al.Predictors of survival in patients with soft tissue surgical margin involvement at radical cystectomy[J].Ann Surg Oncol, 2013, 20 (3):1027-1034.
[27] Rink M, Hansen J, Cha E K, et al.Outcomes and prognostic factors in patients with a single lymph node metastasis at time of radical cystectomy[J].BJU Int, 2013, 111 (1):74-84.
[28] Zhou H, Ro J Y, Truong L D, et al.Intraoperative frozen section evaluation of ureteral and urethral margins:studies of 203consecutive radical cystoprostatectomy for men with bladder urothelial carcinoma[J].Am J Clin Exp Urol, 2014, 2 (2):156-160.
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