血清OPN水平与桂西地区壮族人群上尿路草酸钙结石的关系

周威; 黄群; 孟冬冬; 黄敏玉

doi:10.13201/j.issn.1001-1420.2019.10.004

血清OPN水平与桂西地区壮族人群上尿路草酸钙结石的关系

- 右江民族医学院附属医院泌尿外科(广西百色, 533000)
基金项目:
国家自然科学基金（编号81600541）

详细信息

通讯作者: 黄群,E-mail:huangqundao@163.com

中图分类号: R691.4

收稿日期: 2019-06-05

Relationship between serum OPN level and upper urinary calcium oxalate stone in the Zhuang from Western Guangxi

- Department of Urology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, 533000, China

More Information

Corresponding author: HUANG Qun, E-mail: huangqundao@163.com

Received Date: 05 June 2019

摘要

摘要: 目的：探讨桂西地区壮族人群血清骨桥蛋白（OPN）水平与上尿路草酸钙（CaOx）结石的关系。方法：选取住院的50例壮族上尿路结石患者作为结石组，术后通过结石红外光谱分析仪进行结石成分分析；收集同期来院的正常壮族体检者50例作为对照组。采用酶联免疫试验测定结石组和对照组血清OPN浓度，并比较两组之间的差异。结果：结石组血清OPN浓度显著低于对照组（P<0.001）；同性别的结石组与对照组血清OPN浓度比较，差异无统计学意义（P>0.05）；结石组的男性与女性血清OPN浓度均低于同性别对照组的血清OPN浓度（P<0.01，P<0.05）；纯CaOx患者血清OPN浓度显著低于对照组（P<0.01）；一水草酸钙（COM）+二水草酸钙（COD）+碳酸磷灰石（CA.AP）患者与对照组血清OPN浓度比较，差异无统计学意义（P>0.05）；COM、COD+CA.AP患者血清OPN浓度高于纯CaOx患者（P<0.05）。结论：在桂西地区壮族人群中，血清OPN可能抑制上尿路CaOx结石的形成，这种抑制作用与性别之间无相关性，但在同性别人群中，上调血清OPN水平可抑制CaOx结石的形成；纯CaOx结石内混合CA.AP可能使血清OPN水平升高。
- 草酸钙结石 /
- 骨桥蛋白 /
- 桂西地区 /
- 壮族
Abstract: Objective: To explore the relationship between serum osteopontin(OPN) level and calcium oxalate stone in upper urinary tract of the Zhuang from Western Guangxi. Method: We selected 50 cases of upper urinary stones in the Zhuang as the stone group. The stones were analyzed by infrared spectroscopy after operation. Other 50 persons of the Zhuang who came to the hospital during the same period were selected as the control group. Serum OPN concentrations in stone group and control group were measured by enzyme-linked immunoassay, and the difference between the two groups was compared. Result: The serum OPN concentration in stone group was significantly lower than that in control group(P<0.001). There was no significant difference in serum OPN concentration between the stone group and the control group with the same sex(P>0.05). Serum OPN concentration in stone group in male and female patients was lower than that in control group with the same sex. The serum OPN concentration of pure CaOx patients was lower than that of the control group. The serum OPN concentration of patients with COM+COD+CA.AP had no significant difference compared with that of the control group(P>0.05). The serum OPN concentration of patients with COM+COD+CA.AP was higher than that of patients with pure CaOx(P<0.05).Conclusion: Serum OPN may inhibit the formation of CaOx stones in the Zhuang from Western Guangxi, and there is no correlation between the inhibitory effect and sex. But up-regulation of serum OPN level may inhibit the formation of CaOx stones in population with the same sex. Mixed CA.AP in pure CaOx stone may increase serum OPN level.
- calcium oxalate stones /
- osteopontin /
- Western Guangxi /
- the Zhuang

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