达泊西汀联合坦索罗辛治疗早泄的应用效果及安全性研究

付桥; 张景宇; 王芳芳; 张志超; 杨军; 张炜

doi:10.13201/j.issn.1001-1420.2019.10.007

达泊西汀联合坦索罗辛治疗早泄的应用效果及安全性研究

- 武汉市第三医院泌尿外科(武汉, 430060)

详细信息

通讯作者: 张景宇,E-mail:344649225@qq.com

中图分类号: R698

收稿日期: 2018-02-08

Therapeutic effect and safety of dapoxetine and tamsulosin in the treatment of premature ejaculation

- Department of Urology, Third People's Hospital of Wuhan City, Wuhan, 430060, China

More Information

Corresponding author: ZHANG Jingyu, E-mail: 344649225@qq.com

Received Date: 08 February 2018

摘要

摘要: 目的：探讨达泊西汀联合坦索罗辛治疗早泄（PE）的临床疗效及安全性。方法：选择我院2016年1月1日~2016年12月31日收治的PE患者120例，随机数字法将所有患者分为对照组与观察组，其中观察组60例，患者给予达泊西汀联合坦索罗辛治疗；对照组60例，单纯给予达泊西汀治疗。分别于治疗前及治疗后1、3、6个月比较两组患者阴道射精潜伏期（IELT）、临床总体印象变化（CGIC）、PE评估量表（PEP）、不良反应发生率的差异。结果：治疗前两组患者各项指标比较差异均无统计学意义（P>0.05），治疗后1、3、6个月，两组患者的平均IELT均较治疗前明显增加（P<0.05），且观察组IELT明显高于对照组（P<0.05）；观察组CGIC的总有效率明显高于对照组（93.3% vs.71.7%，P<0.05）；观察组治疗后6个月控制射精能力、性交满意度、PE相关苦恼及PE相关夫妻沟通困难评分均高于对照组（P<0.05）；观察组的不良反应发生率明显低于对照组（9.94% vs.21.67%，P<0.05）。结论：达泊西汀联合坦索罗辛治疗PE疗效显著，能够延长IELT，提高性生活质量，且不良反应较少，适宜临床推广。
- 早泄 /
- 达泊西汀 /
- 坦索罗辛 /
- 临床疗效 /
- 安全性
Abstract: Objective: To explore the clinical efficacy and safety of dapoxetine combined with tamsulosin in the treatment of premature ejaculation(PE). Method: One hundred and twenty patients with PE who were admitted to our hospital from January 1 st, 2016 to December 31 st, 2016 were selected. All patients were divided into control group and observation group by random number method. Among them, observation group was 60 cases. Patients were given dapoxetine combined with tamsulosin; control group, 60 cases, simply given dapoxetine. Before treatment, 1 month, 3 months, and 6 months after treatment, intravaginal ejaculation latency time(IELT), clinical global impression change(CGIC), premature ejaculation profile(PEP) and incidence of adverse reactions were compared between the two groups. Result: There was no significant difference in each index between the two groups before treatment(P>0.05). After one month, three months and six months of treatment, the average IELT of all patients increased significantly(P<0.05). The observation group was significantly higher than the control group(P<0.05); the total effective rate of the CGIC in the observation group was 93.3%, which was significantly higher than 71.7% in the control group(P<0.05); the observation group had control of ejaculation ability 6 months after treatment. The scores of sexual intercourse satisfaction, premature ejaculation-related distress, and premature ejaculation-related couple communication difficulties were all higher than those in the control group(P<0.05). The incidence of adverse reactions in the observation group was 9.94%, which was significantly lower than that in the control group of 21.67%(P<0.05).Conclusion: Dapoxetine combined with tamsulosin is effective in the treatment of PE, which can prolong IELT, improve the quality of sexual life, and decrease adverse reactions. It is suitable for clinical promotion.
- premature ejaculation /
- dapoxetine /
- tamsulosin /
- clinical efficacy /
- safety

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