膀胱壁内注射A型肉毒素加水扩张并灌注透明质酸钠治疗间质性膀胱炎的疗效观察

刘建光; 孔斌; 杨明州; 杨进益

doi:10.13201/j.issn.1001-1420.2019.10.016

膀胱壁内注射A型肉毒素加水扩张并灌注透明质酸钠治疗间质性膀胱炎的疗效观察

- 大连医科大学附属大连市友谊医院泌尿外科(大连, 116001)

详细信息

通讯作者: 杨进益,E-mail:yangjinyi90@hotmail.com

中图分类号: R694

收稿日期: 2018-06-13

Observation of curative effect for treatment of IC with injection of BTX-A to bladder wall combination of bladder hydrodistention and intravesical perfusion of sodium hyaluronate

- Department of Urology, Affiliated Dalian Friendship Hospital of Dalian Medical University, Dalian, Liaoning, 116001, China

More Information

Corresponding author: YANG Jinyi, E-mail: yangjinyi90@hotmail.com

Received Date: 13 June 2018

摘要

摘要: 目的：总结我院治疗间质性膀胱炎（IC）的成果，探索IC最佳治疗方法。方法：我院2010年6月~2018年6月采用3种不同治疗方法治疗78例IC患者，其中28例采用膀胱壁内注射A型肉毒素加水扩张并灌注透明质酸钠治疗（A组），30例采用膀胱水扩张加膀胱灌注透明质酸钠治疗（B组），20例采用膀胱水扩张术治疗（C组），分析比较三组治疗前、治疗6周、治疗6个月后IC症状指数（ICSI）及治疗效果。结果：78例患者均获得满意随访。A组效果显著23例、有效5例、无效0例；B组效果显著15例、有效10例、无效5例；C组效果显著6例、有效6例、无效8例。A组有效率为100%，B组有效率为83.3%，C组有效率为60.0%。治疗前、治疗6周及治疗6个月后ICSI评分均较治疗前明显降低，A组与B组、C组间治疗6周及6个月后有效率比较差异均有统计学意义（P<0.01）。结论：膀胱黏膜下注射A型肉毒素加水扩张并灌注透明质酸钠治疗IC较膀胱水扩张加膀胱灌注透明质酸钠及单纯膀胱水扩张疗效明显，是治疗IC的有效手段。
- 间质性膀胱炎 /
- A型肉毒素 /
- 透明质酸钠
Abstract: Objective: To summarize the experience of different treatments for interstitial cystitis(IC) so as to find out the best choice. Method: From June 2010 to June 2018, 78 IC patients were studied, and they were divided into three groups. Group A included 28 subjects, and they were given the treatment of injection of BTX-A to bladder wall combination of bladder hydrodistention and intravesical perfusion of sodium hyaluronate. Group B included 30 subjects, and they were given the treatment of bladder hydrodistention and intravesical perfusion of sodium hyaluronate. Group C included 20 subjects, and they were only given the treatment of bladder hydrodistention. Interstitial cystitis symptom index(ICSI) of the three groups before the treatment, 6 weeks after treatment, 6 months after treatment were evaluated and compared among the three groups. Result: All 78 subjects were followed up for 6 months. In group A 23 subjects acquired significant curative effect, 5 subjects were effective, 0 subject was ineffective. In group B 15 subjects acquired significant curative effect, 10 subjects were effective, 5 subjects were ineffective. In group C 6 subjects acquired significant curative effect, 6 subjects were effective, 8 subjects were ineffective. The effective rate of group A, B and C were 100%, 83.3% and 60.0% respectively. ICSI reduced significantly 6 weeks and 6 months after treatment. There was significant difference in the effective rate among group A, B and C 6 weeks and 6 months after treatment(P<0.01).Conclusion: IC treatment with injection of BTX-A to bladder wall combination of bladder hydrodistention and intravesical perfusion of sodium hyaluronate shows obvious curative effect, which is better than the treatment of bladder hydrodistention and intravesical perfusion of sodium hyaluronate or bladder hydrodistention merely.
- interstitial cystitis /
- BTX-A /
- sodium hyaluronate

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