衰老微环境对非肌层浸润性膀胱癌预后的影响及机制初步探讨

王尚任; 张爱巧; 黄诗桥; 王波; 马勇; 杨永姣; 刘晓强; 张鲁东; 王站成

doi:10.13201/j.issn.1001-1420.2020.03.007

衰老微环境对非肌层浸润性膀胱癌预后的影响及机制初步探讨

- 1. 单县中心医院济宁医学院附属湖西医院泌尿外科(山东菏泽, 274300);
- 2. 天津医科大学总医院泌尿外科
基金项目:
山东省医药卫生科技发展计划项目(No:2017ws106)

详细信息

通讯作者: 马勇,E-mail:15264095500@163.com

中图分类号: R737.14

收稿日期: 2018-10-07

Influence of aged microenvironment upon the prognosis of non-muscle-invasive bladder cancer and preliminary research on its mechanism

- 1. Department of Urology, Shanxian Central Hospital, Heze, Shandong, 274300, China;
- 2. Department of Urology, Tianjin Medical University General Hospital

More Information

Corresponding author: MA Yong, E-mail: 15264095500@163.com

Received Date: 07 October 2018

摘要

摘要: 目的:探讨衰老微环境对非肌层浸润性膀胱癌(NMIBC)预后的影响并初步探讨相关机制。方法:选取单县中心医院初诊的NMIBC患者81例,按照患者年龄分为低龄组(<65岁)和高龄组(≥65岁)两组,比较分析两组患者无复发生存期及无进展生存期,采用Cox回归模型分析影响NMIBC患者预后的危险因素。并留取同期癌旁正常膀胱黏膜组织30例作为对照,采用免疫组化法检测分析正常膀胱黏膜、低龄组及高龄组NMIBC中分泌型Frizzled相关蛋白2(secreted frizzled-related proteins 2,sFRP2)及β-catenin的表达水平。结果:低龄组患者的无复发生存率和无进展生存率均高于高龄组患者(P<0.05),多因素分析发现年龄是NMIBC患者复发和进展的独立危险因素。sFRP2在低龄组及高龄组NMIBC组织中,表达的阳性率均低于正常膀胱黏膜(P<0.05);高龄组sFRP2的表达阳性率明显高于低龄组(P<0.05)。β-catenin低龄组及高龄组NMIBC组织中表达的阳性率均高于正常膀胱黏膜组织(P<0.05);高龄组β-catenin的表达阳性率明显低于低龄组(P<0.05)。结论:衰老微环境可能在膀胱癌的发生发展中发挥了一定作用。sFRP2及β-catenin可能参与了衰老微环境对膀胱癌发生发展过程的调控。
- 衰老微环境 /
- 非肌层浸润性膀胱癌 /
- sFRP2 /
- β-catenin /
- 预后
Abstract: Objective: To investigate the prognosis of human non-muscle-invasive bladder cancer in aged microenvironment, and investigate the related molecular mechanisms. Method: According to the age,81 patients of non-muscle-invasive bladder cancer were divided into young group(<65 years old) and aged group(≥65 years old).The recurrence-free survival(RFS) and progression-free survival(PFS) of two groups were analyzed. Risk factors influencing prognosis of non-muscle-invasive bladder cancer were analyzed by using the Cox proportional hazards regression model. The expressions of sFRP2 and β-catenin were detected by immunohistochemical method in normal bladder tissues, young and aged groups of non-muscle-invasive bladder cancer tissues. Result: The recurrence and progression rates in the aged group is higher than those in the young group, and the RFS and PFS were shorter(P<0.05).In the multivariable Cox analysis, we found that age was an independent predictor of RFS and PFS. Compared with normal bladder tissue,sFRP2 was lowly expressed in both young and aged groups of non-muscle-invasive bladder cancer tissues(P<0.05).The level of sFRP2 was significantly higher in the aged group than that in the young group(P<0.05). Higher expression of β-catenin was found in both young and aged groups of non-muscle-invasive bladder cancer tissues compared with the normal bladder tissue(P<0.05).The level of β-catenin was significantly lower in the aged group than that in the young group(P<0.05).Conclusion: The aged microenvironment is an important factor influencing the survival rate of the patients with bladder cancer. In aged microenvironment,sFRP2 and β-catenin are closely correlated with the carcinogenesis and progression of non-muscle-invasive bladder cancer in the aged microenvironment.
- aged microenvironment /
- non-muscle-invasive bladder cancer /
- secreted frizzled-related proteins 2 /
- β-catenin /
- prognosis

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