Abstract: Objective: To analyze and summarize 13 cases of arterial rupture of DCD renal transplantation. Method: A retrospective analysis was performed on 617 DCD kidney transplanted recipients from organ transplantation center of Zhengzhou People's Hospital, including 13 cases of renal artery rupture caused by infection factors. Pathogenic microorganisms were searched through multiple ways of donor and recipient to determine the source of infection. Result: The time of artery rupture was 6-86 days after the operation. The pathogenic microorganisms causing artery rupture included aspergillus, mucor, tropical candida, klebsiella pneumoniae and serratia mucosa. Ten of the patients had their renal grafts removed, and one had the graft preserved by interventional therapy. Three cases died of massive gastrointestinal bleeding, severe pneumonia and hemorrhagic shock.Conclusion: Before organ donation, the donor's blood, urine and wound secretions and other body fluids should be taken for etiological monitoring. Anti-infective therapy with sensitive drugs should be given to the cultured positive donors, and the ineffective ones should be discarded decisively. When one recipient of the same donor suffers from renal artery rupture, another recipient should also be highly valued and given empirical anti-infective drugs immediately. If the infection cannot be controlled, the transplanted kidney should be removed as soon as possible according to the principle of "life first and kidney second". For the donor kidney with a long history and uncertain infectious factors, broad-spectrum antibacterials combined with antifungal drugs should be used to prevent infection after operation, and the treatment plan should be adjusted in time according to the culture results and drug sensitivity test.