预测非梗阻性无精子症精子获取因素的研究进展

王希涛; 郝林; 张文达; 周荣升; 韩从辉

doi:10.13201/j.issn.1001-1420.2020.12.015

预测非梗阻性无精子症精子获取因素的研究进展

- 1. 徐州市中心医院泌尿外科(江苏徐州, 221009);
- 2. 东南大学医学院
基金项目:
江苏省妇幼健康科研项目资助(No:F201561)

详细信息

通讯作者: 韩从辉,E-mail:hanchdoctor@qq.com

中图分类号: R697

收稿日期: 2019-06-16

Advances in predictive factors of testicular sperm extraction in men with non-obstructive azoospermia

- 1. Department of Urology, Xuzhou Central Hospital, Jiangsu, Xuzhou, 221009, China;
- 2. Medical School of Southeast University

More Information

Corresponding author: HAN Conghui, E-mail: hanchdoctor@qq.com

Received Date: 16 June 2019

摘要

摘要: 非梗阻性无精子症(NOA)目前常通过睾丸取精技术结合卵胞浆内单精子注射技术(ICSI),使其获得生育的可能。而睾丸取精技术在不断的发展,睾丸细针穿刺抽吸术(TFNA)、睾丸切开取精术(TESE)、显微睾丸切开取精术(MD-TESE)等技术得到广泛的应用,但是目前仍然缺少可靠的术前预测因素来判断能否成功获取精子。是否可使用特定标记物或非侵入的检查方法对精子获取进行预测,从而避免不必要手术,许多学者进行了多方面的研究。目前已有的预测指标有血清与精浆激素类指标、睾丸指标、影像学和光学技术、Y染色体微缺失、分子蛋白指标、核酸指标等。本文对NOA精子获取的预测因素作一综述。
- 男性不育 /
- 非梗阻性无精子症 /
- 预测因素
Abstract: Men with non-obstructive azoospermia(NOA) can achieve fertility by testicular sperm extraction combined with intracytoplasmic sperm injection(ICSI). The testicular sperm extraction methods, such as testicular fine needle aspiration(TFNA), testicular sperm extraction(TESE), and microdissection testicular sperm extraction(MD-TESE) are widely used in the treatment of NOA. However, there is still lack of reliable preoperative predictors to determine whether sperm can be successfully obtained. Whether non-invasive methods can be used to predict sperm extraction, many scholars have conducted various studies. Nowadays some predictors come into notice, including serum and seminal plasma hormones marker, testicular markers, imaging and optical techniques, Y chromosome micro-deletion, molecule protein indicators and nucleic acid indicators. This article reviews the reliable predictive factors of testicular sperm extraction in NOA.
- male infertility /
- non-obstructive azoospermia /
- predictive factors

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