感染性结石的相关临床易感因素研究

苏晓伟; 王大明; 丁德茂; 谢栋栋; 章大钊; 吕洁; 于德新

doi:10.13201/j.issn.1001-1420.2021.04.008

感染性结石的相关临床易感因素研究

- 安徽医科大学第二附属医院泌尿外科(合肥, 230601)

详细信息

通讯作者: 于德新,E-mail:Urology_ydx@126.com

中图分类号: R691.4

收稿日期: 2020-10-12

Clinical factors associated with susceptibility to infection stone formation

- Department of Urology, Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China

More Information

Corresponding author: YU Dexin, E-mail: Urology_ydx@126.com

Received Date: 12 October 2020

摘要

摘要: 目的:探讨感染性结石的相关临床易感因素,并且分析各种结石成分的临床特点差异。方法:回顾性分析2015年6月—2020年8月于安徽医科大学第二附属医院行手术治疗的上尿路结石患者,根据结石成分分析分为草酸钙结石组、感染性结石组、尿酸结石组,将各临床因素与感染性结石的相关性进行Logistic回归分析,采用方差分析或卡方检验分析3组临床特点差异。结果:1604例患者纳入研究,草酸钙结石组1087例,感染性结石组250例,尿酸结石组267例,感染性结石的发生与患者年龄、女性、尿路感染、尿细菌培养阳性有显著相关性,与其他因素无相关性,3组临床特点分析有显著差异(P＜0.05),感染性结石组年龄最小,感染性结石组在女性患者比例、结石复发率、尿路感染比例、尿细菌培养阳性比例及尿pH值显著高于其他两组,尿培养最多的细菌为大肠埃希菌。结论:感染性结石的发生与年龄、女性、尿路感染、尿细菌培养阳性明显相关,感染性结石的发生趋向年轻化,非脲酶细菌明显增多。
- 感染性结石 /
- 临床易感因素 /
- 鸟粪石 /
- 碳酸磷灰石
Abstract: Objective: To investigate the clinical factors associated with susceptibility to infection stone formation and to analyze the variations in the clinical characteristics of stones with different compositions.Methods: We retrospectively analysed patients with upper urinary calculi who underwent surgical treatment in Second Affiliated Hospital of Anhui Medical University from June 2015 to August 2020. The patients were divided into calcium oxalate stone group, infectious stone group and uric acid stone group according to the analysis of stone composition. The correlation between clinical factors and infectious stones were analyzed by logistic regression analysis. The clinical characteristics of the three groups were analyzed by ANOVA or chi square test.Results: A total of 1604 patients were included in the study. There were 1087 cases in calcium oxalate stone group, 250 cases in infectious stone group and 267 cases in uric acid stone group. The occurrence of infection stones was significantly associated with the patient's age, female, urinary tract infection and positive urine bacterial culture. It has nothing to do with other factors. There was significant difference in clinical characteristics among the three groups(P＜0.05). The infection stone group was the youngest. The proportion of female patients, stone recurrence rate, urinary tract infection rate, positive rate of urinary bacterial culture and urine pH value in the infectious stone group were significantly higher than those in the other two groups. Escherichia coli was the most cultured bacteria in urine.Conclusion: The incidence of infectious stones was significantly correlated with age, female, urinary tract infection and positive culture of urinary bacteria. In addition, the incidence of infectious stones tended to be younger and non-urease bacteria increased significantly.
- infection stone /
- clinical susceptibility factors /
- struvite calculus /
- apatite carbonate

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