超声造影剂在肾细胞癌中的研究进展

葛胜东; 邰胜

doi:10.13201/j.issn.1001-1420.2021.04.018

超声造影剂在肾细胞癌中的研究进展

葛胜东,
邰胜^,

- 安徽医科大学第一附属医院泌尿外科(合肥, 230000)

详细信息

通讯作者: 邰胜,E-mail:taishengwk@163.com

中图分类号: R737.11

收稿日期: 2020-04-09

Advance of ultrasound microbubble contrast agents in renal cell carcinoma

GE Shengdong,
TAI Sheng^,

- Department of Urology, First Affiliated Hospital of Anhui Medical University, Hefei, 230000, China

More Information

Corresponding author: TAI Sheng, E-mail: taishengwk@163.com

Received Date: 09 April 2020

摘要

摘要: 肾细胞癌是常见的泌尿系统恶性肿瘤。目前肾细胞癌的诊断、治疗主要通过CT检查、外科手术及术后化疗等方法实现。肾细胞癌超声微泡造影剂具有器官或组织靶向性、增强显像和血管穿透性。可以携带药物或基因穿过肿瘤血管外组织并且诱导释放,有效地增强传递同时减少不良反应,促进了肾细胞癌在分子水平治疗的发展。
- 超声 /
- 微泡造影剂 /
- 肾细胞癌 /
- 诊断 /
- 治疗
Abstract: Renal cell carcinoma is a common malignant tumor of the urinary system. At present, the diagnosis and treatment of renal cell carcinoma are mainly achieved by CT examination, surgery, and postoperative chemotherapy. Renal cell carcinoma ultrasound microbubble contrast agent has organ or tissue targeting, enhanced imaging, and strengthened vascular permeability. It can carry drugs or genes through the extravascular tissue of tumors and induce release, effectively enhance delivery and reduce side effects, and promote the development of renal cell carcinoma treatment at the molecular level.
- ultrasound /
- microbubble contrast agent /
- renal cell carcinoma /
- diagnosis /
- treatment

HTML全文

参考文献(49)

[1]	Siegel RL,Miller KD,Jemal A.Cancer statistics,2019[J].CA Cancer J Clin,2019,69(1):7-34.
[2]	Capitanio U,Montorsi F.Renal cancer[J].Lancet,2016,387(10021):894-906.
[3]	Sennoga CA,Kanbar E,Auboire L,et al.Microbubble-mediated ultrasound drug-delivery and therapeutic monitoring[J].Expert Opin Drug Deliv,2017,14(9):1031-1043.
[4]	Hull TD,Agarwal A,Hoyt K.New Ultrasound Techniques Promise Further Advances in AKI and CKD[J].J Am Soc Nephrol,2017,28(12):3452-3460.
[5]	Sennoga CA,Kanbar E,Auboire L,et al.Microbubble-mediated ultrasound drug-delivery and therapeutic monitoring[J].Expert Opin Drug Deliv,2017,14(9):1031-1043.
[6]	Mullick Chowdhury S,Lee T,Willmann J K.Ultrasound-guided drug delivery in cancer[J].Ultrasonography,2017,36(3):171-184.
[7]	Min HS,Son S,You DG,et al.Chemical gas-generating nanoparticles for tumor-targeted ultrasound imaging and ultrasound-triggered drug delivery[J].Biomaterials,2016,108:57-70.
[8]	Cao Y,Chen Y,Yu T,et al.Drug Release from Phase-Changeable Nanodroplets Triggered by Low-Intensity Focused Ultrasound[J].Theranostics,2018,8(5):1327-1339.
[9]	Roovers S,Segers T,Lajoinie G,et al.The Role of Ultrasound-Driven Microbubble Dynamics in Drug Delivery:From Microbubble Fundamentals to Clinical Translation[J].Langmuir,2019,35(31):10173-10191.
[10]	Chen Y,Liang Y,Jiang P,et al.Lipid/PLGA Hybrid Microbubbles as a Versatile Platform for Noninvasive Image-Guided Targeted Drug Delivery[J].ACS Appl Mater Interfaces,2019,11(45):41842-41852.
[11]	Luo W,Wen G,Yang L,et al.Dual-targeted and pH-sensitive Doxorubicin Prodrug-Microbubble Complex with Ultrasound for Tumor Treatment[J].Theranostics,2017,7(2):452-465.
[12]	Lu N,Wang L,Lv M,et al.Graphene-based nanomaterials in biosystems[J].Nano Res,2019,12(2):247-264.
[13]	Kim H,Kim J,Lee M,et al.Stimuli-Regulated Enzymatically Degradable Smart Graphene-Oxide-Polymer Nanocarrier Facilitating Photothermal Gene Delivery[J].Adv Healthc Mater,2016,5(15):1918-1930.
[14]	Kalluru P,Vankayala R,Chiang CS,et al.Nano-graphene oxide-mediated In vivo fluorescence imaging and bimodal photodynamic and photothermal destruction of tumors[J].Biomaterials,2016,95:1-10.
[15]	Zullino S,Argenziano M,Stura I,et al.From Micro-to Nano-Multifunctional Theranostic Platform:Effective Ultrasound Imaging Is Not Just a Matter of Scale[J].Mol Imaging,2018,17:1536012118778216.
[16]	阳孟君,王洛夫,郭燕丽,等.携载G250单克隆抗体的纳米微泡靶向于肾细胞癌的体内外实验研究[J].第三军医大学学报,2016,38(2):112-118.
[17]	Li M,Luo H,Zhang W,et al.Phase-shift,targeted nanoparticles for ultrasound molecular imaging by low intensity focused ultrasound irradiation[J].Int J Nanomedicine,2018,13:3907-3920.
[18]	Fan Z,Kumon RE,Deng CX.Mechanisms of microbubble-facilitated sonoporation for drug and gene delivery[J].Ther Deliv,2014,5(4):467-86.
[19]	Tian Y,Liu Z,Tan H,et al.New Aspects of Ultrasound-Mediated Targeted Delivery and Therapy for Cancer[J].Int J Nanomedicine,2020,15:401-418.
[20]	Min H S,You D G,Son S,et al.Echogenic Glycol Chitosan Nanoparticles for Ultrasound-Triggered Cancer Theranostics[J].Theranostics,2015,5(12):1402-1418.
[21]	Zhu L,Zhao H,Zhou Z,et al.Peptide-Functionalized Phase-Transformation Nanoparticles for Low Intensity Focused Ultrasound-Assisted Tumor Imaging and Therapy[J].Nano Lett,2018,18(3):1831-1841.
[22]	Turajlic S,Swanton C,Boshoff C.Kidney cancer:The next decade[J].J Exp Med,2018,215(10):2477-2479.
[23]	Hudson JM,Bailey C,Atri M,et al.The prognostic and predictive value of vascular response parameters measured by dynamic contrast-enhanced-CT,-MRI and-US in patients with metastatic renal cell carcinoma receiving sunitinib[J].Eur Radiol,2018,28(6):2281-2290.
[24]	Stock K,Kübler H,Maurer T,et al.CEUS-diagnosis of solid renal tumors[J].Radiologe,2018,58(6):553-562.
[25]	Rübenthaler J,Negrao de Figueiredo G,Mueller-Peltzer K,et al.Evaluation of renal lesions using contrast-enhanced ultrasound(CEUS);a 10-year retrospective European single-centre analysis[J].Eur Radiol,2018,28(11):4542-4549.
[26]	Tordjman M,Dbjay J,Chamouni A,et al.Clear Cell Papillary Renal Cell Carcinoma:A Recent Entity With Distinct Imaging Patterns[J].AJR Am J Roentgenol,2020,214(3):579-587.
[27]	Jorge S,Pereira K,López-Fernández H,et al.Ultrasonic-assisted extraction and digestion of proteins from solid biopsies followed by peptide sequential extraction hyphenated to MALDI-based profiling holds the promise of distinguishing renal oncocytoma from chromophobe renal cell carcinoma[J].Talanta,2020,206:120180.
[28]	Mueller-Peltzer K,Negrao de Figueiredo G,Graf T,et al.Papillary renal cell carcinoma in contrast-enhanced ultrasound(CEUS)-A diagnostic performance study[J].Clin Hemorheol Microcirc,2019,71(2):159-164.
[29]	Thaiss WM,Bedke J,Kruck S,et al.Can contrast-enhanced ultrasound and acoustic radiation force impulse imaging characterize CT-indeterminate renal masses?A prospective evaluation with histological confirmation[J].World J Urol,2019,37(7):1339-1346.
[30]	Calio BP,Lyshchik A,Li J,et al.Long Term Surveillance of Renal Cell Carcinoma Recurrence Following Ablation using 2D and 3D Contrast-Enhanced Ultrasound[J].Urology,2018,121:189-196.
[31]	Hudson JM,Williams R,Karshafian R,et al.Quantifying vascular heterogeneity using microbubble disruption-replenishment kinetics in patients with renal cell cancer[J].Invest Radiol,2014,49(2):116-23.
[32]	Hudson JM,Bailey C,Atri M,et al.The prognostic and predictive value of vascular response parameters measured by dynamic contrast-enhanced-CT,-MRI and-US in patients with metastatic renal cell carcinoma receiving sunitinib[J].Eur Radiol,2018,28(6):2281-2290.
[33]	Wang H,Lutz AM,Hristov D,et al.Intra-Animal Comparison between Three-dimensional Molecularly Targeted US and Three-dimensional Dynamic Contrast-enhanced US for Early Antiangiogenic Treatment Assessment in Colon Cancer[J].Radiology,2017,282(2):443-452.
[34]	Eschbach RS,Clevert DA,Hirner-Eppeneder H,et al.Contrast-Enhanced Ultrasound with VEGFR2-Targeted Microbubbles for Monitoring Regorafenib Therapy Effects in Experimental Colorectal Adenocarcinomas in Rats with DCE-MRI and Immunohistochemical Validation[J].PLoS One,2017,12(1):e0169323.
[35]	Baetke SC,Rix A,Tranquart F,et al.Squamous Cell Carcinoma Xenografts:Use of VEGFR2-targeted Microbubbles for Combined Functional and Molecular US to Monitor Antiangiogenic Therapy Effects[J].Radiology,2016,278(2):430-440.
[36]	胡劼,苏海砾,宗瑜瑾,等.利用载舒尼替尼的多聚体微泡实现超声介导的靶向药物运输:实验研究[J].中国医学影像技术,2013,29(2):161-164.
[37]	Hu J,Zong Y,Li J,et al.In Vitro and In Vivo Evaluation of Targeted Sunitinib-Loaded Polymer Microbubbles Against Proliferation of Renal Cell Carcinoma[J].J Ultrasound Med,2016,35(3):589-97.
[38]	Mullick Chowdhury S,Wang TY,Bachawal S,et al.Ultrasound-guided therapeutic modulation of hepatocellular carcinoma using complementary microRNAs[J].J Control Release,2016,238:272-280.
[39]	Wang TY,Choe JW,Pu K,et al.Ultrasound-guided delivery of microRNA loaded nanoparticles into cancer[J].J Control Release,2015,203:99-108.
[40]	Husain SR,Han J,Au P,et al.Gene therapy for cancer:regulatory considerations for approval[J].Cancer Gene Ther,2015,22(12):554-563.
[41]	Huang S,Ren Y,Wang X,et al.Application of Ultrasound-Targeted Microbubble Destruction-Mediated Exogenous Gene Transfer in Treating Various Renal Diseases[J].Hum Gene Ther,2019,30(2):127-138.
[42]	Li F,Jin L,Wang H,et al.The dual effect of ultrasound-targeted microbubble destruction in mediating recombinant adeno-associated virus delivery in renal cell carcinoma:transfection enhancement and tumor inhibition[J].J Gene Med,2014,16(1-2):28-39.
[43]	Rothe M,Schambach A,Biasco L.Safety of gene therapy:new insights to a puzzling case[J].Curr Gene Ther,2014,14(6):429-36.
[44]	Doi K,Takeuchi Y.Gene therapy using retrovirus vectors:vector development and biosafety at clinical trials[J].Uirusu,2015,65(1):27-36.
[45]	Tse LV,Moller-Tank S,Asokan A.Strategies to circumvent humoral immunity to adeno-associated viral vectors[J].Expert Opin Biol Ther,2015,15(6):845-855.
[46]	Suzuki R,Namai E,Oda Y,et al.Cancer gene therapy by IL-12 gene delivery using liposomal bubbles and tumoral[J].J Control Release,2010,142(2):245-250.
[47]	Zhou Y,Gu H,Xu Y,et al.Targeted antiangiogenesis gene therapy using targeted cationic microbubbles conjugated with CD105 antibody compared with untargeted cationic and neutral microbubbles[J].Theranostics,2015,5(4):399-417.
[48]	Park DH,Jung BK,Lee YS,et al.Evaluation of in vivo antitumor effects of ANT2 shRNA delivered using PEI and ultrasound with microbubbles[J].Gene Ther,2015,22(4):325-332.
[49]	Kopechek JA,Carson AR,Mctiernan CF,et al.Ultrasound Targeted Microbubble Destruction-Mediated Delivery of a Transcription Factor Decoy Inhibits STAT3 Signaling and Tumor Growth[J].Theranostics,2015,5(12):1378-1387.