Analysis of key issue of diagnosis and treatment of perioperative urinary tract infection in PCNL
-
摘要: 经皮肾镜取石术(PCNL)是目前治疗>2 cm上尿路结石的“金标准”,围手术期合并尿路感染是PCNL术后引发尿源性感染相关并发症的重要危险因素,围手术期准确、高效的诊断尿路感染不仅对预判术后感染具有重要价值,更对制定抗菌药物的应用策略具有指导意义。本文旨在结合当前国内外研究现状,对PCNL围手术期尿路感染的诊断、治疗及临床意义进行总结,探讨PCNL围手术期关于尿路感染仍需注意的关键问题以及今后需要关注的方向。Abstract: Percutaneous nephrolithotomy(PCNL) is the "gold standard" for the treatment of upper urinary tract calculi larger than 2 cm. Perioperative urinary tract infection is an important risk factor for infection-related complications after PCNL. Accurate and efficient diagnosis of perioperative urinary tract infection in PCNL could not only predict postoperative infection, but also direct antimicrobial medicine application strategy. In current issue, the status quo of nowadays of diagnosis and treatment of perioperative urinary tract infection in PCNL, as well as the clinical significance are summarized. Furthermore, the key problems related to the perioperative urinary tract infection in PCNL are explored and the future direction in this field are considered accordingly.
-
Key words:
- percutaneous nephrolithotomy /
- urinary tract infection /
- diagnosis /
- treatment /
- antimicrobial medicine
-
-
[1] Türk C,Petćík A,Sarica K,et al.EAU Guidelines on Interventional Treatment for Urolithiasis[J].Eur Urol,2016,69(3):475-482.
[2] Assimos D,Krambeck A,Miller NL,et al.Surgical Management of Stones:American Urological Association/Endourological Society Guideline,PART II[J].J Urol,2016,196(4):1161-1169.
[3] 李为兵.经皮肾镜碎石取石术并发症及其防治[J].中华泌尿外科杂志,2012,33(1):10-12.
[4] Michel MS,Trojan L,Rassweiler JJ.Complications in percutaneous nephrolithotomy[J].Eur Urol,2007,51(4):899-906.
[5] 贾灵华,王金根.经皮肾镜取石术相关尿源性脓毒症的研究进展[J].中华泌尿外科杂志,2012,33(4):312-315.
[6] 栾光超,王勤章,钱彪,等.经皮肾镜术后尿源性脓毒血症相关危险因素的Meta分析[J/OL].中华腔镜泌尿外科杂志(电子版),2019,13(2):103-107.
[7] Chen D,Jiang C,Liang X,et al.Early and rapid prediction of postoperative infections following percutaneous nephrolithotomy in patients with complex kidney stones[J].BJU Int,2019,123(6):1041-1047.
[8] 王清松.尿、结石细菌培养对预测PCNL致尿脓毒血症发生的价值[D].重庆:重庆医科大学,2015.
[9] Dogan HS,Guliyev F,Cetinkaya YS,et al.Importance of microbiological evaluation in management of infectious complications following percutaneous nephrolithotomy[J].Int Urol Nephrol,2007,39(3):737-742.
[10] McCartney AC,Clark J,Lewi HJ.Bacteriological study of renal calculi[J].Eur J Clin Microbiol,1985,4(6):553-555.
[11] Benson AD,Juliano TM,Miller NL.Infectious outcomes of nephrostomy drainage before percutaneous nephrolithotomy compared to concurrent access[J].J Urol,2014,192(3):770-774.
[12] Mariappan P,Smith G,Bariol SV,et al.Stone and pelvic urine culture and sensitivity are better than bladder urine as predictors of urosepsis following percutaneous nephrolithotomy:a prospective clinical study[J].J Urol,2005,173(5):1610-1614.
[13] 马楠,李虎,黄志强,等.尿路结石并发感染患者尿液亚硝酸盐与白细胞检测分析[J].实用临床医药杂志,2018,22(17):68-70,74.
[14] Espinosa-Ortiz EJ,Eisner BH,Lange D,et al.Current insights into the mechanisms and management of infection stones[J].Nat Rev Urol,2019,16(1):35-53.
[15] 吴文起,肖成林,梁叶萍,等.上尿路结石细菌培养的临床意义[J].现代泌尿外科杂志,2013,18(1):19-22.
[16] 吴文起,吴伟宙,钟芳灵,等.草酸钙结石尿路大肠埃希菌的特征分析[J].临床外科杂志,2019,27(2):102-104.
[17] El-Nahas AR,Shokeir AA,El-Assmy AM,et al.Post-percutaneous nephrolithotomy extensive hemorrhage:a study of risk factors[J].J Urol,2007,177(2):576-579.
[18] Flannigan R,Choy WH,Chew B,et al.Renal struvite stones--pathogenesis,microbiology,and management strategies[J].Nat Rev Urol,2014,11(6):333-341.
[19] Chen D,Zhang Y,Huang J,et al.The analysis of microbial spectrum and antibiotic resistance of uropathogens isolated from patients with urinary stones[J].Int J Clin Pract,2018,72(6):e13205.
[20] Paonessa JE,Gnessin E,Bhojani N,et al.Preoperative Bladder Urine Culture as a Predictor of Intraoperative Stone Culture Results Clinical Implications and Relationship to Stone Composition[J].J Urol,2016,196(3):769-774.
[21] 王彭,于江,张建军,等.上尿路结石尿细菌培养结果与结石成分相关性的研究[J/OL].泌尿外科杂志(电子版),2011,3(4):23-24,32.
[22] 陈东,张玉艳,蓝创歆,等.泌尿系结石患者尿液菌谱特征分析[J].中华泌尿外科杂志,2016,37(11):855-859.
[23] 李江,陈勇,邹庆波.肾结石患者尿路感染病原菌分布与耐药性分析[J].中华医院感染学杂志,2015,25(17):3881-3883.
[24] 潜力,李伟.肾结石并尿路感染215例病原菌分布及耐药性分析[J].现代泌尿外科杂志,2013,18(5):493-494,517.
[25] 刘晓龙.上尿路结石术前尿培养细菌谱分析及抗生素的应用[D].天津:天津医科大学,2014.
[26] 张玉艳,蓝创歆,陈东,等.泌尿系结石患者尿路大肠埃希菌感染的临床特点及药物敏感性分析[J].中国现代医学杂志,2018,28(10):94-98.
[27] 乔庐东,陈山,马小军,等.上尿路结石患者围手术期抗菌药物应用的专家意见[J].中华泌尿外科杂志,2017,38(9):641-643.
[28] Kumar A,Roberts D,Wood KE,et al.Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock[J].Crit Care Med,2006,34(6):1589-1596.
-
计量
- 文章访问数: 994
- PDF下载数: 727
- 施引文献: 0