外周血雄雌激素水平及雄雌激素比与前列腺增生的相关性研究

刘玉明; 陆凯; 葛建章; 王光宇

doi:10.13201/j.issn.1001-1420.2021.06.008

外周血雄雌激素水平及雄雌激素比与前列腺增生的相关性研究

- 南华大学附属长沙中心医院泌尿外科(长沙, 410000)
基金项目:
湖南省自然科学基金(No:2018JJ2453)

详细信息

通讯作者: 刘玉明,E-mail:yu1320731@163.com

中图分类号: R697.3

收稿日期: 2020-11-23

Correlation between estrogen and androgen level of peripheral blood and estrogen to androgen ratio and prostatic hyperplasia

- Department of Urology, Changsha Central Hospital Affiliated to University of South China, Changsha, 410000, China

More Information

Corresponding author: LIU Yuming, E-mail: yu1320731@163.com

Received Date: 23 November 2020

摘要

摘要: 目的:探讨外周血雄激素(T)、雌激素(E2)及雄雌比与前列腺增生(BPH)的相关性。方法:选取我院体检中心及泌尿外科2019年8月—2020年8月期间的体检人员(n=136)及BPH住院患者(n=61);收集并分析两组外周血T、E2、T/E2、PSA及前列腺B超。结果:随年龄的增长,雄激素(T)水平出现下降,与年龄表现低度线性负相关,其相关系数R=-0.11(|R|<0.4);雌激素(E2)没有变化,趋势线几乎呈水平线。T/E2与年龄呈现低度线性负相关,其相关系数R=-0.15(|R|<0.4);前列腺体积增大,与年龄变化表现为显著性线性正相关,相关系数R=0.56(0.4<|R|<0.7)。T与前列腺体积呈低度线性负相关,其相关系数R=-0.006(|R|<0.4);E2与前列腺体积表现低度线性正相关,相关系数R=0.12(|R|<0.4);T/E2与前列腺体积表现低度线性负相关,相关系数R=-0.18(|R|<0.4)。BPH组与正常组E2水平之间差异无统计学意义(P>0.05);BPH组与正常组对比,T和T/E2差异有统计学意义(P<0.05)。结论:BPH患者与外周血T、E2及T/E2均存在相关性。
- 前列腺增生 /
- 雌激素 /
- 雄激素 /
- 雄雌比
Abstract: Objective: To investigate the correlation between peripheral blood androgen(T), estrogen(E2) and T/E2 ratio and benign prostatic hyperplasia(BPH).Methods: From August 2019 to August 2020, 197 cases of BPH and normal controls admitted to urology department and physical examination center of our hospital were selected and divided into BPH and normal control group. Peripheral blood T, E2, T/E2, PSA and prostate B ultrasound were collected and analyzed.Results: With the increase of age, the level of androgen decreased, which was negatively correlated with the low age expression. The correlation coefficient was R=-0.11(|R|<0.4); estrogen did not change, and the trend line was almost horizontal. T/E2 has a low degree of linear negative correlation with age, and the correlation coefficient was R=-0.15(|R|<0.4). The increase of prostate volume was significantly positively correlated with age, with the correlation coefficient R=0.56(0.4<|R|<0.7). There was a low degree of linear negative correlation between T and prostate volume, and the correlation coefficient was R=-0.006(|R|<0.4). E2 had a low degree of linear positive correlation with the prostate volume expression, with the correlation coefficient R=0.12(|R|<0.4). T/E2 was negatively correlated with low-degree linear and linear prostate volume expression, with the correlation coefficient R=-0.18(|R|<0.4). There was no significant difference in E2 level between BPH group and normal group(P>0.05). There was significant difference in T and T/E between the BPH group and the normal group(P<0.05).Conclusion: BPH patients are correlated with peripheral blood T, E2 and T/E2
- benign prostatic hyperplasia /
- estrogen /
- androgen /
- androgen-to-estrogen ratio

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