前列腺癌双极雄激素治疗的研究进展

尤祥云, 孙德明, 喻俊峰, 等. 前列腺癌双极雄激素治疗的研究进展[J]. 临床泌尿外科杂志, 2021, 36(12): 989-992. doi: 10.13201/j.issn.1001-1420.2021.12.015
引用本文: 尤祥云, 孙德明, 喻俊峰, 等. 前列腺癌双极雄激素治疗的研究进展[J]. 临床泌尿外科杂志, 2021, 36(12): 989-992. doi: 10.13201/j.issn.1001-1420.2021.12.015
YOU Xiangyun, SUN Deming, YU Junfeng, et al. Advances in the treatment of prostate cancer with bipolar androgen therapy[J]. J Clin Urol, 2021, 36(12): 989-992. doi: 10.13201/j.issn.1001-1420.2021.12.015
Citation: YOU Xiangyun, SUN Deming, YU Junfeng, et al. Advances in the treatment of prostate cancer with bipolar androgen therapy[J]. J Clin Urol, 2021, 36(12): 989-992. doi: 10.13201/j.issn.1001-1420.2021.12.015

前列腺癌双极雄激素治疗的研究进展

  • 基金项目:

    湖北省自然科学基金面上类项目(No:2020CFB379);三峡大学学位论文培优基金项目(No:2020SSPY108);宜昌市财政科技专项基金(No:A20-2-021)

详细信息
    通讯作者: 向振东,E-mail:druid456@msn.com
  • 中图分类号: R737.25

Advances in the treatment of prostate cancer with bipolar androgen therapy

More Information
  • 双极雄激素治疗(bipolar androgen therapy,BAT)是去势抵抗性前列腺癌(castration resistant prostate cancer,CRPC)的新疗法,可显著降低部分患者血清前列腺癌特异性抗原(prostate specific antigen,PSA)水平、提高患者生活质量和恢复去势治疗的敏感性,在CRPC患者的治疗中展现了巨大潜力,本文对BAT在前列腺癌中的相关研究进展作一综述。
  • 加载中
  • [1]

    Fitzmaurice C, Akinyemiju TF, Al Lami FH, et alet al.Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2016:A Systematic Analysis for the Global Burden of Disease Study[J].JAMA Oncol, 2018, 4(11):1553-1568.

    [2]

    Feng RM, Zong YN, Cao SM, et al.Current cancer situation in China:good or bad news from the 2018 Global Cancer Statistics?[J].Cancer Commun(Lond), 2019, 39(1):22.

    [3]

    刘成成, 石春雷, 石菊芳, 等.2015-2017年中国城市居民肿瘤预防意识健康素养及相关因素分析[J].中华预防医学杂志, 2020, 68(1):47-53.

    [4]

    El-Amm J, Aragon-Ching JB.The Current Landscape of Treatment in Non-Metastatic Castration-Resistant Prostate Cancer[J].Clin Med Insights Oncol, 2019, 13:1179554919833927.

    [5]

    Xie T, Song XL, Wang C, et al.The role of androgen therapy in prostate cancer:from testosterone replacement therapy to bipolar androgen therapy[J].Drug Discov Today, 2021, 26(5):1293-1301.

    [6]

    Evans CP.Bipolar androgen therapy:an intriguing paradox[J].Lancet Oncol, 2018, 19(1):8-10.

    [7]

    Liu RJ, Hu Q, Li SY, et al.The Role of Androgen Receptor Splicing Variant 7 in Predicting the Prognosis of Metastatic Castration-Resistant Prostate Cancer:Systematic Review and Meta-Analysis[J].Technol Cancer Res Treat, 2021, 20:15330338211035260.

    [8]

    Schiewer MJ, Knudsen KE.DNA Damage Response in Prostate Cancer[J].Cold Spring Harb Perspect Med, 2019, 9(1):a030486.

    [9]

    Chatterjee P, Schweizer MT, Lucas JM, et al.Supraphysiological androgens suppress prostate cancer growth through androgen receptor-mediated DNA damage[J].J Clin Invest, 2019, 130:4245-4260.

    [10]

    Kokal M, Mirzakhani K, Pungsrinont T, et al.Mechanisms of Androgen Receptor Agonist-and Antagonist-Mediated Cellular Senescence in Prostate Cancer[J].Cancers(Basel), 2020, 12(7):1833.

    [11]

    Lam HM, Nguyen HM, Labrecque MP, et al.Durable Response of Enzalutamide-resistant Prostate Cancer to Supraphysiological Testosterone Is Associated with a Multifaceted Growth Suppression and Impaired DNA Damage Response Transcriptomic Program in Patient-derived Xenografts[J].Eur Urol, 2020, 77(2):144-155.

    [12]

    Intasqui P, Bertolla RP, Sadi MV.Prostate cancer proteomics:clinically useful protein biomarkers and future perspectives[J].Expert Rev Proteomics, 2018, 15(1):65-79.

    [13]

    Batra A, Winquist E.Emerging cell cycle inhibitors for treating metastatic castration-resistant prostate cancer[J].Expert Opin Emerg Drugs, 2018, 23(4):271-282.

    [14]

    Icard P, Fournel L, Wu Z, et al.Interconnection between Metabolism and Cell Cycle in Cancer[J].Trends Biochem Sci, 2019, 44(6):490-501.

    [15]

    Burkhart DL, Morel KL, Sheahan AV, et al.The Role of RB in Prostate Cancer Progression[J].Adv Exp Med Biol, 2019, 1210:301-318.

    [16]

    Gravina GL, Marampon F, Sanita P, et al.Episode-like pulse testosterone supplementation induces tumor senescence and growth arrest down-modulating androgen receptor through modulation of p-ERK1/2, pAR(ser81) and CDK1 signaling:biological implications for men treated with testosterone replacement therapy[J].Oncotarget, 2017, 8(69):113792-113806.

    [17]

    Leone G, Buttigliero C, Pisano C, et al.Bipolar androgen therapy in prostate cancer:Current evidences and future perspectives[J].Crit Rev Oncol Hematol, 2020, 152:102994.

    [18]

    Sugiura M, Sato H, Kanesaka M, et al.Epigenetic modifications in prostate cancer[J].Int J Urol, 2021, 28(2):140-149.

    [19]

    Joly-Pharaboz MO, Ruffion A, Roch A, et al.Inhibition of growth and induction of apoptosis by androgens of a variant of LNCaP cell line[J].J Steroid Biochem Mol Biol, 2000, 73(5):237-249.

    [20]

    Kim JH, Lee H, Shin EA, et al.Implications of Bcl-2 and its interplay with other molecules and signaling pathways in prostate cancer progression[J].Expert Opin Ther Targets, 2017, 21(9):911-920.

    [21]

    Etheridge T, Damodaran S, Schultz A, et al.Combination therapy with androgen deprivation for hormone sensitive prostate cancer:A new frontier[J].Asian J Urol, 2019, 6(1):57-64.

    [22]

    Thomas L, Baratchian M, Sharifi N.Supraphysiologic Testosterone Solutions for Enzalutamide-resistant Prostate Cancer[J].Eur Urol, 2020, 77(2):156-157.

    [23]

    Schweizer MT, Antonarakis ES, Wang H, et al.Effect of bipolar androgen therapy for asymptomatic men with castration-resistant prostate cancer:results from a pilot clinical study[J].Sci Transl Med, 2015, 7(269):269ra2.

    [24]

    Bluemn EG, Coleman IM, Lucas JM, et al.Androgen Receptor Pathway-Independent Prostate Cancer Is Sustained through FGF Signaling[J].Cancer Cell, 2017, 32(4):474-489 e6.

    [25]

    Schweizer MT, Wang H, Luber B, et al.Bipolar Androgen Therapy for Men With Androgen Ablation Naive Prostate Cancer:Results From the Phase ⅡBATMAN Study[J].Prostate, 2016, 76(13):1218-1226.

    [26]

    Teply BA, Wang H, Luber B, et al.Bipolar androgen therapy in men with metastatic castration-resistant prostate cancer after progression on enzalutamide:an open-label, phase 2, multicohort study[J].Lancet Oncol, 2018, 19(1):76-86.

    [27]

    Markowski MC, Shenderov E, Eisenberger MA, et al.Extreme responses to immune checkpoint blockade following bipolar androgen therapy and enzalutamide in patients with metastatic castration resistant prostate cancer[J].Prostate, 2020, 80(5):407-411.

    [28]

    Markowski MC, Wang H, Sullivan R, et al.A Multicohort Open-label Phase II Trial of Bipolar Androgen Therapy in Men with Metastatic Castration-resistant Prostate Cancer(RESTORE):A Comparison of Post-abiraterone Versus Post-enzalutamide Cohorts[J].Eur Urol, 2021;79(5):692-699.

    [29]

    Markowski MC, Silberstein JL, Eshleman JR, et al.Clinical Utility of CLIA-Grade AR-V7 Testing in Patients With Metastatic Castration-Resistant Prostate Cancer[J].JCO Precis Oncol, 2017, 2017:PO.17.00127.

    [30]

    Denmeade SR, Wang H, Agarwal N, et al.TRANSFORMER:A Randomized Phase II Study Comparing Bipolar Androgen Therapy Versus Enzalutamide in Asymptomatic Men With Castration-Resistant Metastatic Prostate Cancer[J].J Clin Oncol, 2021, 39(12):1371-1382.

    [31]

    Denmeade SR.Bipolar androgen therapy in the treatment of prostate cancer[J].Clin Adv Hematol Oncol, 2018, 16(6):408-411.

  • 加载中
计量
  • 文章访问数:  1231
  • PDF下载数:  1457
  • 施引文献:  0
出版历程
收稿日期:  2020-09-28

目录