Effect of lipoic acid combined with vitamin E and L-carnitine in improving sperm DNA integrity
-
摘要: 目的 观察抗氧化剂硫辛酸联合维生素E及左卡尼汀在改善精子DNA完整性中的作用。方法 本研究共纳入2020年7—12月因精子DNA碎片化指数(DFI)过高在同济医院生殖男科门诊就诊的男性不育患者84例，分为硫辛酸组(43例)和对照组(41例)。硫辛酸组予以服用硫辛酸胶囊(0.2 g，tid)，配合维生素E胶囊(100 mg，tid)及左卡尼汀口服液(1 g，tid)；对照组仅予以维生素E及左卡尼汀口服液治疗，用药3个月后复查精液常规及DFI，比较治疗前后以及组间的差异。结果 治疗后两组患者的精子浓度、精子总数、前向运动精子百分率及正常形态精子百分率较治疗前均有提高，精子DFI水平均低于治疗前；两组比较显示，硫辛酸组的DFI显著低于对照组(13.68% vs.25.45%，P < 0.05)。结论 在使用维生素E和左卡尼汀改善精子DNA完整性时，联合使用硫辛酸可获得更好的疗效。Abstract: Objective To investigate the effect of antioxidant lipoic acid (LA) combined with vitamin E and L-carnitine in improving sperm DNA integrity.Methods Eighty-four men visiting andrology office in Reproductive Medicine Center of Tongji Hospital between July and December in 2020 because of infertility and an elevated sperm DNA fragmentation index (DFI) were divided into LA group (n=43) and the control group (n=41) according to whether or not LA (0.2 g, tid) were added to the conventional treatment using vitamin E (100 mg, tid) and L-carnitine (1 g, tid). The treatment lasted for 3 months and then semen were examined for conventional parameters and DFI.Results Semen parameters such as concentration, total count, progressive motility, normal morphology were elevated and DFI were reduced in both groups. In LA group, the level of DFI after treatment was significantly lower than in control group.Conclusion Better effect may be achieved by adding lipoid acid when using vitamin E and L-carnitine to improve sperm DNA integrity.
-
Key words:
- lipoic acid /
- sperm /
- DNA integrity /
- antioxidant /
- male infertility
-
-
表 表 1 两组患者治疗前后精液参数的比较
指标 硫辛酸组(n=43) 对照组(n=41) P1 P2 P3 P4 治疗前 治疗后 治疗前 治疗后 精液体积/mL 2.86±1.38 3.01±2.00 2.83±1.76 3.15±1.69 0.532 0.136 0.094 0.361 精子浓度/(×106·mL-1) 16.96(5.85) 24.52(6.72) 18.03(5.94) 23.90(7.23) 0.197 0.028 0.032 0.427 精子总数/(×106/次射精) 38.65(13.62) 71.99(21.38) 36.76(14.08) 68.74(20.56) 0.329 0.031 0.036 0.156 前向运动精子百分率/% 31.85(6.58) 58.93(11.66) 29.86(5.32) 53.62(10.89) 0.281 0.010 0.017 0.086 正常形态精子百分率/% 4.38±0.67 7.68±1.12 3.92±0.81 5.84±0.98 0.094 0.015 0.021 0.048 精子DFI/% 35.62±10.55 13.68±7.4 36.11±11.86 25.45±8.85 0.121 0.008 0.013 0.024 注：P1：硫辛酸组治疗前与对照组治疗前比较；P2：硫辛酸组治疗前与治疗后比较；P3：对照组治疗前与治疗后比较；P4：硫辛酸组治疗后与对照组治疗后比较。 
下载: 导出CSV
-
[1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11] [12] [13] [14] [15] [16] [17] [18] [19] -