-
摘要: 肾上腺肿瘤术后顽固性低血压临床上较为少见,国内外仅见零星个案报道,本文报道1例66岁女性患者,因左侧腰痛不适1年,发现左侧肾上腺占位1周入院。术前诊断为左侧肾上腺肿瘤、高血压、甲状腺次全切术后。于腹腔镜下实施左侧肾上腺部分切除术,术后患者出现进行血压下降,通过积极补液、大剂量激素和肾上腺素能受体激动剂治疗无效,加用垂体后叶素有效。本文通过回顾性分析肾上腺肿瘤患者的病例资料、术前准备、术中及术后诊疗措施,分析术后出现顽固性低血压的原因,总结加用垂体后叶素抢救成功的经验。Abstract: Refractory hypotension after adrenal tumor operation is relatively rare in clinic, and only sporadic cases have been reported at home and abroad. This paper reports a 66-year-old female patient who was admitted to the hospital because of left low back pain for 1 year and left adrenal mass for 1 week. Preoperative diagnosis was left adrenal tumor, hypertension, and partial thyroidectomy. After laparoscopic partial adrenalectomy on the left side, the patient experienced a decrease in blood pressure after surgery, which failed to be treated with active fluid replacement, high-dose hormone and adrenergic receptor agonist, but pituitrin was effective. This paper retrospectively analyzed the case data, preoperative preparation, intraoperative and postoperative diagnosis and treatment measures of patients with adrenal tumor, analyzed the causes of postoperative refractory hypotension, and summarized the successful experience of adding pituitrin to rescue patients.
-
Key words:
- adrenal tumors /
- hypotension /
- pituitrin /
- ɑ-receptor blocker
-
[1] Crimì F, Quaia E, Cabrelle G, et al. Diagnostic Accuracy of CT Texture Analysis in Adrenal Masses: A Systematic Review[J]. Int J Mol Sci, 2022, 23(2): 637. doi: 10.3390/ijms23020637
[2] 李春建, 王健明. 肾上腺偶发瘤的诊疗进展[J/OL]. 泌尿外科杂志(电子版), 2021, 13(2): 92-95.
[3] Lenders J, Kerstens MN, Amar L, et al. Genetics, diagnosis, management and future directions of research of phaeochromocytoma and paraganglioma: a position statement and consensus of the Working Group on Endocrine Hypertension of the European Society of Hypertension[J]. J Hypertens, 2020, 38(8): 1443-1456. doi: 10.1097/HJH.0000000000002438
[4] Buitenwerf E, Osinga TE, Timmers H, et al. Efficacy of α-Blockers on Hemodynamic Control during Pheochromocytoma Resection: A Randomized Controlled Trial[J]. J Clin Endocrinol Metab, 2020, 105(7): 2381-2391. doi: 10.1210/clinem/dgz188
[5] 李星, 朱云鹏, 汪静, 等. 高血压伴无肾上腺激素生化异常的肾上腺偶发瘤外科治疗疗效及预后因素分析[J]. 临床泌尿外科杂志, 2021, 36(7): 513-518. https://www.cnki.com.cn/Article/CJFDTOTAL-LCMW202107002.htm
[6] Fang F, Ding L, He Q, et al. Preoperative Management of Pheochromocytoma and Paraganglioma[J]. Front Endocrinol(Lausanne), 2020, 11: 586795. doi: 10.3389/fendo.2020.586795
[7] Buscemi S, Di Buono G, D'Andrea R, et al. Perioperative Management of Pheochromocytoma: From a Dogmatic to a Tailored Approach[J]. J Clin Med, 2021, 10(16): 3759. doi: 10.3390/jcm10163759
[8] Patel D. Surgical approach to patients with pheochromocytoma[J]. Gland Surg, 2020, 9(1): 32-42. doi: 10.21037/gs.2019.10.20
[9] Kim JH, Lee HC, Kim SJ, et al. Perioperative hemodynamic instability in pheochromocytoma and sympathetic paraganglioma patients[J]. Sci Rep, 2021, 11(1): 18574. doi: 10.1038/s41598-021-97964-3
[10] Chiba D, Hada Y, Numahata K, et al. A case of pheochromocytoma crisis with persistent hypotension successfully managed with vasopressin[J]. Urol Case Rep, 2021, 38: 101664. doi: 10.1016/j.eucr.2021.101664
[11] Heesen M, Carvalho B, Carvalho J, et al. International consensus statement on the use of uterotonic agents during caesarean section[J]. Anaesthesia, 2019, 74(10): 1305-1319. doi: 10.1111/anae.14757
[12] Li W, Wang G, Lin T. Application of laparoscopic tourniquet in myomectomy[J]. Int J Gynaecol Obstet, 2020, 148(1): 124-125. doi: 10.1002/ijgo.12966
[13] Kislitsina ON, Rich JD, Wilcox JE, et al. Shock-Classification and Pathophysiological Principles of Therapeutics[J]. Curr Cardiol Rev, 2019, 15(2): 102-113. doi: 10.2174/1573403X15666181212125024
[14] Yoon S, Kim YK. The Role of the Oxytocin System in Anxiety Disorders[J]. Adv Exp Med Biol, 2020, 1191: 103-120.
[15] Török B, Fazekas CL, Szabó A, et al. Epigenetic Modulation of Vasopressin Expression in Health and Disease[J]. Int J Mol Sci, 2021, 22(17): 9415. doi: 10.3390/ijms22179415