肿瘤相关成纤维细胞在膀胱癌发生发展中的研究进展

叶峻江; 吴睿成; 李登雄; 韩平

doi:10.13201/j.issn.1001-1420.2023.10.014

肿瘤相关成纤维细胞在膀胱癌发生发展中的研究进展

- 四川大学华西医院泌尿外科(成都，610041)
基金项目:
四川省卫生健康委项目(No：21PJ041)；成都市科技局重点研发支持计划(No：2022-YF05-01568-SN)

详细信息

通讯作者: 韩平，E-mail：hanping@scu.edu.cn

中图分类号: R737.14

收稿日期: 2023-03-27

刊出日期: 2023-10-06

Research progress of tumor-associated fibroblasts in the genesis and development of bladder cancer

- Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, 610041, China

More Information

Corresponding author: HAN Ping, E-mail: hanping@scu.edu.cn

Received Date: 27 March 2023

Publish Date: 06 October 2023

摘要

摘要: 肿瘤相关成纤维细胞作为肿瘤微环境中主要的间质细胞，可以通过改造肿瘤微环境，影响肿瘤的发生发展。膀胱癌是泌尿系统最常见的恶性肿瘤之一，具有易复发、易进展的特点。尽管接受了多种治疗措施，膀胱癌患者的预后仍差。近年来的研究发现，肿瘤相关成纤维细胞在膀胱癌的发生发展中起重要作用，并且与膀胱癌多种耐药机制相关。因此，本文归纳了近年来肿瘤相关成纤维细胞在膀胱癌的研究进展，总结了肿瘤相关成纤维细胞在膀胱癌发生发展中的作用，以及利用肿瘤相关成纤维细胞改进膀胱癌治疗的潜在可能，期望进一步推动膀胱癌肿瘤微环境的研究。
- 膀胱癌 /
- 肿瘤相关成纤维细胞 /
- 肿瘤微环境
Abstract: Cancer-associated fibroblasts, as the main stromal cells in the tumor microenvironment, can affect the genesis and development of tumors by modifying the tumor microenvironment. Bladder cancer is one of the most common malignant tumors in the urinary system, with high rate of recurrence and progression. Despite various therapeutic measures, the prognosis of patients with bladder cancer remains poor. Recent studies have found that cancer-associated fibroblasts play an important role in the genesis and development of bladder cancer, and are related to a variety of drug resistance mechanisms of bladder cancer. Therefore, this article summarizes the research progress of cancer-associated fibroblasts in bladder cancer in recent years, summarizes the role of cancer-associated fibroblasts in the occurrence and development of bladder cancer, and the potential of targeting cancer-associated fibroblasts to improve the treatment of bladder cancer, hoping to further promote the study of bladder cancer tumor microenvironment.
- bladder cancer /
- cancer-associated fibroblasts /
- tumor microenvironment

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