-
摘要: 膀胱癌是泌尿系统常见的恶性肿瘤之一。相关研究指出，人乳头状瘤病毒(human papillomavirus，HPV)感染可能与膀胱癌的发生发展有一定的病因相关性。然而，HPV感染与膀胱癌之间的关系仍存在争议和不确定，至今仍未达成共识。因此，本文收集整理相关文献资料，阐述HPV在膀胱肿瘤的致病机制，综述HPV感染与膀胱癌的流行病学和病理特征研究，为膀胱癌的早诊早治提供理论依据和新的思路。Abstract: Bladder cancer is one of the common malignant tumors of the urinary system. Relevant studies have pointed out that human papillomavirus(HPV) infection may have some etiological correlation with the occurrence and development of bladder cancer. However, the relationship between HPV infection and bladder cancer is still controversial and uncertain, and no consensus has been reached so far. Therefore, this article collects and collates relevant literature, expounds the pathogenic mechanism of HPV in bladder cancer, reviews the epidemiological and pathological characteristics of HPV infection and bladder cancer, in order to provide theoretical basis and new ideas for early diagnosis and treatment of bladder cancer.
-
Key words:
- bladder cancer /
- human papillomavirus /
- correlation /
- prevalence
-
-
[1] Lobo N, Afferi L, Moschini M, et al. Epidemiology, Screening, and Prevention of Bladder Cancer[J]. Eur Urol Oncol, 2022, 5(6): 628-639. doi: 10.1016/j.euo.2022.10.003
[2] van Hoogstraten L, Vrieling A, van der Heijden AG, et al. Global trends in the epidemiology of bladder cancer: challenges for public health and clinical practice[J]. Nat Rev Clin Oncol, 2023, 20(5): 287-304. doi: 10.1038/s41571-023-00744-3
[3] Dobruch J, Oszczudłowski M. Bladder Cancer: Current Challenges and Future Directions[J]. Medicina(Kaunas), 2021, 57(8): 749.
[4] Wang C, Li L, Wang F, et al. Single-cell transcriptomics dissects epithelial heterogeneity in HPV+ cervical adenocarcinoma[J]. J Med Virol, 2023, 95(2): e28480. doi: 10.1002/jmv.28480
[5] Li X, Zhang M, Lei T, et al. Single-cell RNA-sequencing dissects cellular heterogeneity and identifies two tumor-suppressing immune cell subclusters in HPV-related cervical adenosquamous carcinoma[J]. J Med Virol, 2022, 94(12): 6047-6059. doi: 10.1002/jmv.28084
[6] Pang L, Ding Z, Li F, et al. HPV-16 Expression and Loss of Cell Differentiation in Primary Bladder Tumors[J]. Biomed Res Int, 2022, 2022: 6565620.
[7] Musangile FY, Matsuzaki I, Okodo M, et al. Detection of HPV infection in urothelial carcinoma using RNAscope: Clinicopathological characterization[J]. Cancer Med, 2021, 10(16): 5534-5544. doi: 10.1002/cam4.4091
[8] Collins K, Hwang M, Hamza A, et al. Prevalence of high-risk human papillomavirus in primary squamous cell carcinoma of urinary bladder[J]. Pathol Res Pract, 2020, 216(9): 153084. doi: 10.1016/j.prp.2020.153084
[9] Farshadpour F, Taherkhani R, Farzaneh M. Human papillomaviruses and bladder cancer risk: first report in south of Iran[J]. Virusdisease, 2023, 34(2): 257-262. doi: 10.1007/s13337-023-00819-w
[10] Pešut E, - Dukić A, Lulić L, et al. Human Papillomaviruses-Associated Cancers: An Update of Current Knowledge[J]. Viruses, 2021, 13(11): 2234. doi: 10.3390/v13112234
[11] Yu L, Majerciak V, Zheng ZM. HPV16 and HPV18 Genome Structure, Expression, and Post-Transcriptional Regulation[J]. Int J Mol Sci, 2022, 23(9): 4943. doi: 10.3390/ijms23094943
[12] Sofiani VH, Veisi P, Rukerd M, et al. The complexity of human papilloma virus in cancers: a narrative review[J]. Infect Agent Cancer, 2023, 18(1): 13. doi: 10.1186/s13027-023-00488-w
[13] Yousefi Z, Aria H, Ghaedrahmati F, et al. An Update on Human Papilloma Virus Vaccines: History, Types, Protection, and Efficacy[J]. Front Immunol, 2021, 12: 805695.
[14] Lim J, Lilie H, Kalbacher H, et al. Evidence for direct interaction between the oncogenic proteins E6 and E7 of high-risk human papillomavirus(HPV)[J]. J Biol Chem, 2023, 299(8): 104954. doi: 10.1016/j.jbc.2023.104954
[15] Roman BR, Aragones A. Epidemiology and incidence of HPV-related cancers of the head and neck[J]. J Surg Oncol, 2021, 124(6): 920-922. doi: 10.1002/jso.26687
[16] Scott-Wittenborn N, Fakhry C. Epidemiology of HPV Related Malignancies[J]. Semin Radiat Oncol, 2021, 31(4): 286-296. doi: 10.1016/j.semradonc.2021.04.001
[17] Della Fera AN, Warburton A, Coursey TL, et al. Persistent Human Papillomavirus Infection[J]. Viruses, 2021, 13(2): 321. doi: 10.3390/v13020321
[18] Hussain SS, Lundine D, Leeman JE, et al. Genomic Signatures in HPV-Associated Tumors[J]. Viruses, 2021, 13(10): 1998. doi: 10.3390/v13101998
[19] Li L, Dong X, Tang Y, et al. Deciphering the mechanisms of HPV E6 mutations in the destabilization of E6/E6AP/p53 complex[J]. Biophys J, 2022, 121(9): 1704-1714. doi: 10.1016/j.bpj.2022.03.030
[20] Kono T, Laimins L. Genomic Instability and DNA Damage Repair Pathways Induced by Human Papillomaviruses[J]. Viruses, 2021, 13(9): 1821. doi: 10.3390/v13091821
[21] Wendel SO, Stoltz A, Xu X, et al. HPV 16 E7 alters translesion synthesis signaling[J]. Virol J, 2022, 19(1): 165. doi: 10.1186/s12985-022-01899-8
[22] Balasubramaniam SD, Balakrishnan V, Oon CE, et al. Key Molecular Events in Cervical Cancer Development[J]. Medicina(Kaunas), 2019, 55(7): 384.
[23] Cosper PF, Bradley S, Luo L, et al. Biology of HPV Mediated Carcinogenesis and Tumor Progression[J]. Semin Radiat Oncol, 2021, 31(4): 265-273. doi: 10.1016/j.semradonc.2021.02.006
[24] Porter VL, Marra MA. The Drivers, Mechanisms, and Consequences of Genome Instability in HPV-Driven Cancers[J]. Cancers(Basel), 2022, 14(19): 4623.
[25] Kitamura T, Yogo Y, Ueki T, et al. Presence of human papillomavirus type 16 genome in bladder carcinoma in situ of a patient with mild immunodeficiency[J]. Cancer Res, 1988, 48(24 Pt 1): 7207-7211.
[26] Muresu N, Di Lorenzo B, Saderi L, et al. Prevalence of Human Papilloma Virus Infection in Bladder Cancer: A Systematic Review[J]. Diagnostics(Basel), 2022, 12(7): 1759.
[27] Yan Y, Zhang H, Jiang C, et al. Human Papillomavirus Prevalence and Integration Status in Tissue Samples of Bladder Cancer in the Chinese Population[J]. J Infect Dis, 2021, 224(1): 114-122. doi: 10.1093/infdis/jiaa710
[28] Sarier M, Sepin N, Keles Y, et al. Is There any Association between Urothelial Carcinoma of the Bladder and Human Papillomavirus? A Case-Control Study[J]. Urol Int, 2020, 104(1-2): 81-86. doi: 10.1159/000500467
[29] Zapatka M, Borozan I, Brewer DS, et al. The landscape of viral associations in human cancers[J]. Nat Genet, 2020, 52(3): 320-330 doi: 10.1038/s41588-019-0558-9
[30] Cantalupo PG, Katz JP, Pipas JM. Viral sequences in human cancer[J]. Virology, 2018, 513: 208-216. doi: 10.1016/j.virol.2017.10.017
[31] Sun JX, Xu JZ, Liu CQ, et al. The association between human papillomavirus and bladder cancer: Evidence from meta-analysis and two-sample mendelian randomization[J]. J Med Virol, 2023, 95(1): e28208. doi: 10.1002/jmv.28208
[32] Javanmard B, Barghi MR, Amani D, et al. Human Papilloma Virus DNA in Tumor Tissue and Urine in Different Stage of Bladder Cancer[J]. Urol J, 2019, 16(4): 352-356.
[33] Llewellyn MA, Gordon NS, Abbotts B, et al. Defining the frequency of human papillomavirus and polyomavirus infection in urothelial bladder tumours[J]. Sci Rep, 2018, 8(1): 11290. doi: 10.1038/s41598-018-29438-y
[34] Mete UK, Shenvi S, Singh MP, et al. Human Papillomavirus in Urothelial Carcinoma of Bladder: An Indian study[J]. Int J Appl Basic Med Res, 2018, 8(4): 217-219. doi: 10.4103/ijabmr.IJABMR_91_18
[35] Khatami A, Salavatiha Z, Razizadeh MH. Bladder cancer and human papillomavirus association: a systematic review and meta-analysis[J]. Infect Agent Cancer, 2022, 17(1): 3. doi: 10.1186/s13027-022-00415-5
[36] Li N, Yang L, Zhang Y, et al. Human papillomavirus infection and bladder cancer risk: a meta-analysis[J]. J Infect Dis, 2011, 204(2): 217-223. doi: 10.1093/infdis/jir248
[37] Muresu N, Sotgiu G, Saderi L, et al. Distribution of HPV Genotypes in Patients with a Diagnosis of Anal Cancer in an Italian Region[J]. Int J Environ Res Public Health, 2020, 17(12): 4516. doi: 10.3390/ijerph17124516
[38] Muresu N, Sotgiu G, Saderi L, et al. Italian observational study on HPV infection, E6, and p16 expression in men with penile cancer[J]. Virol J, 2020, 17(1): 161. doi: 10.1186/s12985-020-01424-9
[39] Wu J, Xiao F, Zheng Y, et al. Worldwide trend in human papillomavirus-attributable cancer incidence rates between 1990 and 2012 and Bayesian projection to 2030[J]. Cancer, 2021, 127(17): 3172-3182. doi: 10.1002/cncr.33628
[40] Cai T, Mazzoli S, Meacci F, et al. Human papillomavirus and non-muscle invasive urothelial bladder cancer: potential relationship from a pilot study[J]. Oncol Rep, 2011, 25(2): 485-489.
[41] Shigehara K, Sasagawa T, Kawaguchi S, et al. Etiologic role of human papillomavirus infection in bladder carcinoma[J]. Cancer, 2011, 117(10): 2067-2076. doi: 10.1002/cncr.25777
[42] Nakagawa T, Shigehara K, Kato Y, et al. Are bladder washing samples suitable for investigation of HPV infection in urinary bladder? Comparison in HPV prevalence between urine and washing samples[J]. J Med Virol, 2023, 95(1): e28110. doi: 10.1002/jmv.28110
[43] Urbute A, Rasmussen CL, Belmonte F, et al. Prognostic Significance of HPV DNA and p16INK4a in Anal Cancer: A Systematic Review and Meta-Analysis[J]. Cancer Epidemiol Biomarkers Prev, 2020, 29(4): 703-710. doi: 10.1158/1055-9965.EPI-19-1259
[44] Sun Y, Khan M, Mangiola S, et al. IL17RB and IL17REL Expression Are Associated with Improved Prognosis in HPV-Infected Head and Neck Squamous Cell Carcinomas[J]. Pathogens, 2023, 12(4): 572. doi: 10.3390/pathogens12040572
[45] Lei J, Arroyo-Mühr LS, Lagheden C, et al. Human Papillomavirus Infection Determines Prognosis in Cervical Cancer[J]. J Clin Oncol, 2022, 40(14): 1522-1528. doi: 10.1200/JCO.21.01930
[46] Sarier M, Usta SS, Turgut H, et al. Prognostic value of HPV DNA in Urothelial Carcinoma of the Bladder: A Preliminary Report of 2-Year Follow-up Results[J]. Urol J, 2021, 19(1): 45-49.
[47] Ohadian Moghadam S, Mansori K, Nowroozi MR, et al. Association of human papilloma virus(HPV)infection with oncological outcomes in urothelial bladder cancer[J]. Infect Agent Cancer, 2020, 15: 52. doi: 10.1186/s13027-020-00318-3
[48] Jørgensen KR, Jensen JB. Human papillomavirus and urinary bladder cancer revisited[J]. APMIS, 2020, 128(2): 72-79. doi: 10.1111/apm.13016
[49] Maja SG, Slavica KK, Suad A, et al. Bladder mucinous adenocarcinoma as a diagnostic challenge: a case report[J]. Pan Afr Med J, 2022, 42: 221.
[50] Alexander RE, Williamson SR, Richey J, et al. The expression patterns of p53 and p16 and an analysis of a possible role of HPV in primary adenocarcinoma of the urinary bladder[J]. PLoS One, 2014, 9(4): e95724. doi: 10.1371/journal.pone.0095724
-
计量
- 文章访问数: 503
- PDF下载数: 139
- 施引文献: 0
下载: