Research progress in the key role of corpus cavernosum smooth muscle cell in erectile dysfunction
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摘要: 近年来，勃起功能障碍的发病率呈上升趋势，已成为泌尿系统的常见疾病。阴茎海绵体平滑肌细胞(corpus cavernosum smooth muscle cell，CCSMC)作为阴茎勃起结构的重要组成部分，其完整的舒张-收缩机制是阴茎勃起的重要基础，勃起功能障碍患者CCSMC表现出多种病理变化，如凋亡增加、焦亡及铁死亡水平升高、自噬水平下降、氧化应激水平升高和表型转化等。本文旨在汇总聚焦于CCSMC的勃起功能障碍研究进展，阐明CCSMC在勃起功能障碍中的关键致病作用及其可能的治疗靶点。Abstract: In recent years, the incidence rate of erectile dysfunction(ED) has been on the rise and has become a common disease of the urinary system. The corpus cavernosum smooth muscle cell(CCSMC), as an important component of the penile erection structure, has a complete relaxation-contraction mechanism that is an important foundation for penile erection. Patients with ED exhibit various pathological changes in CCSMC, such as increased apoptosis, upregulated pyroptosis and ferroptosis, decreased autophagy, increased oxidative stress levels, and phenotypic transformation. This article aims to summarize the research progress in ED focusing on CCSMC, and elucidate the key pathogenic role of CCSMC in ED and its potential therapeutics.
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