膜联蛋白Ⅱ的表达与前列腺癌临床病理特征及预后的关系

丁滔; 赵正平; 洪斌; 余万钧; 楼雨蛟; 邹依珩; 杨罗艳

膜联蛋白Ⅱ的表达与前列腺癌临床病理特征及预后的关系

- 1. 上海中医药大学附属普陀医院泌尿外科(上海, 200062);
- 2. 中南大学湘雅二医院泌尿外科
基金项目:
湖南省卫生厅科研计划课题项目（编号B2010-046）

详细信息

通讯作者: 丁滔,E-mail:dingtao1006@126.com

中图分类号: R737.25

收稿日期: 2011-12-11

The correlations between the expression of annexin Ⅱ and clinicopathologic features as well as prognosis of prostate cancer

- 1. Department of Urology, Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, China;
- 2. Department of Urology, the Second Xiangya Hospital, Central South China

More Information

Corresponding author: DING Tao, E-mail: dingtao1006@126.com

Received Date: 11 December 2011

摘要

摘要: 目的：研究膜联蛋白Ⅱ（annexin Ⅱ）表达与前列腺癌（PCa）临床病理特征及预后的关系。方法：采用免疫组织化学方法（SP法）检测annexin Ⅱ在40例前列腺增生症（BPH）和85例PCa标本中的表达情况，统计分析annexin Ⅱ表达与PCa临床病理特征及预后的关系。结果：annexin Ⅱ在PCa、BPH表达阳性率分别是62.4%、92.5%，两者差异有统计学意义（P<0.05），annexin Ⅱ在不同Gleason评分、前列腺特异性抗原（PSA）水平、临床分期、不同危险度PCa中，经统计学分析，它们在各组的差异均有统计学意义（P<0.05），Kaplan-Meier生存曲线分析发现annexin Ⅱ表达阴性PCa患者的生存率显著低于annexin Ⅱ表达阳性（P<0.01），预后分析发现annexin Ⅱ表达阴性性均预示着PCa预后较差（P<0.01）。结论：膜联蛋白Ⅱ表达与PCa的发生、进展及预后有关，可作为PCa诊断的分子标记物及预后判断的独立因子。
- 前列腺癌 /
- 膜联蛋白Ⅱ /
- 临床病理特征 /
- 预后
Abstract: Objective: The aim of our work is to investigate the correlations between the expression of annexin Ⅱ and Clinicopathologic features as well as prognosis of prostate cancer(PCa).Method: All prostate specimens were paraffin-embedded in paraffins and confirmed by the pathological diagnosis.They were divided into two groups:40 BPH,85 PCa.The 85 PCa were further divided into various groups according to Gleason's criterion,Prostate-specific antigen(PSA),risk PCa,clinical stage.Expression of annexin Ⅱ was determined by immunohistochemical staining.The correlation among Expression of annexin Ⅱ and clinicopathologic features were analyzed by SPSS software.Result: The results from immunohistochemical staining showed that the positive ratio of annexin Ⅱ expression were 62.4% in PCa,and 92.5% in BPH.And there were significant difference between the expression of annexin Ⅱ and PCa as well as BPH(P<0.05).The 85 PCa were further divided into various groups according to Gleason,PSA,clinical stage,risk of PCa.And there were significant difference of the expression of annexin Ⅱ among them(P<0.05).Kaplan-Meier survival curve showed that PCa patients with low or negative expression of annexin Ⅱ seem to have a poorly survival rate in comparison to those with positive and strong expression of annexin Ⅱ.Prognosis analysis showed that PCa patients with low or negative expression of annexin Ⅱ seem to have poorly prognosis,and annexin Ⅱ can serve as independent index of prognosis in PCa.Conclusion: Our study indicated that annexin Ⅱ play a key role in the development and progression of prostate cancer.It appeared to that the annexin Ⅱ could be used as the basis index of diagnosis and prognosis for PCa.
- prostate cancer /
- annexin Ⅱ /
- clinicopathologic features /
- prognosis

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