The efficacy and safety of endoscopic fulguration for classic ulcerative type bladder pain syndrome/interstitial cystitis
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摘要: 目的：探讨内镜下电灼术治疗溃疡型膀胱疼痛综合征/间质性膀胱炎患者（bladder pain syndrome/interstitial cystitis；BPS/IC）的临床有效性和安全性。方法：所有患者在膀胱镜检+水扩张后，病理回报明确为非特异性炎症者，排除恶性肿瘤疾病，明确为BPS/IC诊断后，分为溃疡型和非溃疡型。随机选取32例溃疡型BPS/IC患者行膀胱溃疡内镜下电灼术治疗。观察手术治疗前后（术后随访1、3、6个月）病情变化如：临床症状情况（每日排尿次数、最大排尿容量、膀胱区疼痛程度评分）和O'Leary-Sant间质性膀胱炎问卷表评分及生活质量评分（QOL）情况。结果：32例溃疡型BPS/IC患者，男5例，女27例，年龄36~60岁，平均（47.0±6.2）岁；病程1~5年，平均（3.5±1.2）年。本组患者症状改善总有效率78.1%（25/32），其中完全缓解率为53.1%（17/32），部分缓解率为25%（8/32），治疗无效率为21.9%（7/32）。手术治疗后患者平均每日排尿次数、每次排尿量、疼痛程度、O'Leary-Sant评分、生活质量评分与治疗前相比均存在显著改善（P<0.01）。结论：内镜下电灼术治疗溃疡型BPS/IC患者能够有效缓解临床症状和改善生活质量。
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关键词:
- 膀胱疼痛综合征/间质性膀胱炎 /
- 治疗 /
- 内镜下电灼术
Abstract: Objective: To evaluate the efficacy and safety of endoscopic fulguration for classic ulcerative type bladder pain syndrome/interstitial cystitis(BPS/IC).Method: Thirty-two patients with classic ulcerative type BPS/IC were involved in this trial.Clinical symptoms(micturition frequency per day,maximal micturition volume and cystodynia degree score),O'Leary-Sant IC symptom and problem index,and quality of life score were assessed at baseline and then again after operation treatment.Side effects was recorded.Result: There were 5 male and 27 female patients in our study,the average age was 47±6.2(range from 36 to 60),the average duration of symptoms was 3.5±1.2 years(from 1 to 5 years)before treatment.The response rate was 78.1%(25/32),Overall satisfaction was 53.1%(17/32),Partial satisfaction was 25%(8/32),None response rate was 21.9%(7/32).For all patients,the mean voiding times,voiding volume per time,cystodynia degree score,average O'Leary-Sant score,and quality of life score pre-treatment were statistically improved post-treatment respectively,P<0.01. Conclusion: Treating classic ulcerative type BPS/IC patients with endoscopic fulguration can effectively relieve clinical symptom of BPS/IC and improve BPS/IC patients' quality of life and is well tolerated. -
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