TLR-4介导的免疫逃逸信号转导系统在膀胱尿路上皮癌中的表达及意义

崔杰; 王永华; 于芹超; 刘静; 公欣海; 纪传彪

TLR-4介导的免疫逃逸信号转导系统在膀胱尿路上皮癌中的表达及意义

- 1. 青岛大学医学院附属医院泌尿外科(山东青岛, 266000);
- 2. 青岛大学医学院附属医院儿科
基金项目:
国家自然科学基金青年科学基金项目（编号81101932）

详细信息

通讯作者: 王永华,E-mail:doctorwangyonghua@yahoo.cn

中图分类号: R737.14

收稿日期: 2012-09-23

The expression and significance of TLR4-mediated immune escape signal transduction system in bladder urothelial carcinoma

- 1. Department of Urology, the Affiliated Hospital of Medical College, Qingdao University, Qingdao, 266000, China;
- 2. Department of Pediatrics, the Affiliated Hospital of Medical College, Qingdao University

More Information

Corresponding author: WANG Yonghua, E-mail: doctorwangyonghua@yahoo.cn

Received Date: 23 September 2012

摘要

摘要: 目的：探讨TLR-4介导的免疫逃逸信号转导系统在膀胱尿路上皮癌免疫逃逸机制中的作用及其与膀胱癌生物学行为的关系。方法：采用免疫组化染色法检测60例膀胱尿路上皮癌和10例正常膀胱组织中TLR-4、B7-H1、PD-1、Fas及FasL的表达。结果：TLR-4在正常膀胱组织中均有表达，而在膀胱尿路上皮癌中表达有所降低；B7-H1、PD-1、Fas、FasL在正常膀胱组织中无表达或表达极低，而在膀胱尿路上皮癌中的表达均明显增高，并且其表达与肿瘤的病理分级和临床分期密切相关，同时B7-H1表达与复发亦密切相关。结论：TLR-4介导的免疫逃逸信号转导系统可能与膀胱尿路上皮癌的免疫逃逸密切相关，在膀胱尿路上皮癌的发生发展中可能存在着TLR-4介导的免疫逃逸信号转导系统的活化和相关免疫抑制分子表达的上调。
- 膀胱肿瘤 /
- 免疫逃逸
Abstract: Objective: To investigate the mechanism of the TLR-4-mediated immune escape signal transduction system in bladder urothelial carcinoma and their relationship with the biological behavior of bladder cancer. Method: Sampales from 60 patients with bladder urothelial carcinoma and 10 cases with normal bladder tissue were examined for TLR-4, B7-H1, PD-1, Fas and FasL expression by immunohistochemical staining Result: TLR-4 positivity was observed in all normal bladder tissue, while decreased expression in bladder urothelial carcinoma; There were no expression or very low expression of B7-H1, PD-1, Fas and FasL in normal bladder tissue, but in bladder urothelial carcinoma the positive expression of those proteins were significantly higher, and those proteins expression were closely correlated with tumor pothological grade and clinical stage, at the same time the B7-H1 expression was also correlated with recurrence.Conclusion: TLR-4-mediated signal transduction system may be associated with bladder urothelial carcinoma immune escape, and activation of TLR-4-mediated immune escape signal transduction system may exist in the development of bladder urothelial carcinoma and along with TLR-4-mediated signal transduction system related immunosuppressive molecule upregulation.
- bladder urothelial carcinoma /
- immune escape

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