Abstract: Objective: To investigate the clinical efficacy of ureteroscopy and holmium laser in the treatment of iatrogenic lower ureteral injuries.Method: A retrospective analysis was performed of 9 patients (8 women and one man, mean age 48.6 years) who had received ureteroscopy and holmium laser treatment from 2009 to 2012 for postoperatively detected iatrogenic lower ureteral injuries sustained during gynecologic or general surgery, including seven left side ureteral lesions, two right side ureteral lesions. Five cases of iatrogenic ureteral injury occurred in radical hysterectomy, three cases occurred in resection of rectal cancer, and one occurred in the radical resection of uterine recurrent tumor; mainly postoperative symptoms were abdominal and back pain, fever, urinary leakage, increasing urine leakage of drainage tube. Ureteroscopy were performed with the ureteral catheter (F₃/F₅) or zebra guide wire, carefully to identify the fistula into the proximal ureter by the guiding, submucosal suture were crushed and removed by the holmium laser when ureteral ligation atresia, indwelling the F₇ or F₈ double J tube for 2 to 3 months, regular follow-up.Result: All cases were lower ureteral lesions, 1 case was found because of anuria after the operation, seven cases were found leakage of urine a week later, and one case was found after 3 months. One patient was successfully placed double J tube directly, six cases were placed in a double-J tube after ureteroscopy and holmium laser treatment, the leakage of urine were cured after one to seven days, 2 cases were carried ureterocystostomy after failure of ureteroscopy. Double J stent were indwelled in all the cases for 2 to 3 months after extraction, and were followed up for 6 to 12 months. The continuity of the affected side restored urinary tract, ureteral patency, and renal hydroureter significantly reduced or normal, which were confirmed by intravenous urography.Conclusion: The ureteroscopy and holmium laser treatment was an effective technology to cure ureteral lower iatrogenic injury especially for ureteral mistakenly tie, with the advantages of effective and reliable, less invasive, and easily accpted by patients. Compared with traditional open surgery such as repairing or ureterocystostomy, the ureteroscopy did not increase patients' pain and complications, even if minimally invasive treatment failure, but also to help clear lesion location in open surgery.