Clinical observation of therapeutic effectiveness of body-gamma knife in treating the bladder cancer
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摘要: 目的：探讨体部伽玛刀治疗膀胱癌的临床疗效及毒副反应。方法：采用OUR-QGD体部伽玛刀治疗膀胱癌患者40例，根据病灶的三维形状及患者身体状况确定靶点数目、治疗次数及分次剂量。单次治疗剂量为3.0~4.0 Gy，等剂量曲线为50.0%~65.0%，计划靶体积（PTV）覆盖>95.0%临床靶体积（CTV），共计10~12次。根据患者年龄、KPS评分、肿瘤侵及范围、CTV、治疗毒副反应调整治疗剂量。随访6~36个月，平均18个月。结果：所有患者治疗后3个月复查，并进行疗效评价，其中完全缓解13例，部分缓解24例，稳定3例，近期有效率为92.5%（37/40），1年生存率90.0%（36/40）。治疗中与治疗后发生的副反应及放射性损伤均较小。结论：体部伽玛刀是对膀胱癌比较有效的治疗方法，毒副反应较轻，临床应用安全。Abstract: Objective: To investigate the clinical therapeutic effectiveness and side effects of body-gamma knife in treating the bladder cancer.Method: Total of 40 patients with bladder cancer were treated by OUR-QGD body gamma knife. The dosage distribution and other radiotherapeutic plans were established on the basis of the carcinoma position and patient health condition. The dosage was 3.0-4.0 Gy. The isodose curve was 50.0%-65.0%. The target volume(PTV) covered about 95.0% of the clinical target volume(CTV). The radiation was performed 10-12 times for one patients. Adjusting the treating dose based on the age, Karnofsky score, the scope of tumor invasion, CTV and side effect. All the cases were followed-up ranged from 6 to 36 months(averaged 18 months).Result: All patients were reexamined 3 months after the treatment. There was 13 cases with complete response, 24 cases partial response, 3 cases stable disease. The short-term effective rate was 92.5%(37/40). The 1-year survival rate was 90.0%(36/40). The side effect and irradiation injury were found during and after therapy, but could continue having therapy and recover.Conclusion: Body-gamma knife is effective in the treatment of bladder cancer, with mild to moderate side effect and safety in clinical practice.
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Key words:
- bladder cancer /
- body-gamma knife /
- stereotaxic technique
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