尿脱落细胞荧光原位杂交技术在尿路上皮癌诊断中的应用

徐阿祥; 杨素霞; 孙圣坤; 宋勇; 张旭

尿脱落细胞荧光原位杂交技术在尿路上皮癌诊断中的应用

- 中国人民解放军总医院泌尿外科(北京, 100853)

详细信息

通讯作者: 徐阿祥,E-mail:xu_axiang@yahoo.com.cn

中图分类号: R737.14

收稿日期: 2012-05-31

Fluorescence in situ hybridization of urine exfoliative cells in diagnosis of urothelial carcinoma

- Department of Urology, Chinese PLA General Hospital, Beijing, 100853, China

More Information

Corresponding author: XU Axiang, E-mail: xu_axiang@yahoo.com.cn

Received Date: 31 May 2012

摘要

摘要: 目的：分析尿脱落细胞荧光原位杂交技术（FISH）在尿路上皮肿瘤诊断中的应用价值。方法：对205例临床疑诊尿路上皮肿瘤患者的尿脱落细胞进行FISH检测，并与组织病理学结果进行对照，总结FISH检测方法对尿路上皮癌诊断的敏感性与特异性。结果：153例尿路上皮癌、52例非尿路上皮癌患者在术前接受了尿脱落细胞FISH检测，术后均经病理检查确定诊断。FISH检测尿路上皮癌的敏感性为54.2%，特异性为94.2%。结论：尿脱落细胞FISH检测对于诊断尿路上皮癌具有高度的特异性。
- 膀胱肿瘤 /
- 荧光原位杂交 /
- 尿路上皮癌
Abstract: Objective: To investigate the value of fluorescence in situ hybridization of urine exfoliative cells in the diagnosis of urothelial carcinoma.Method: The urine samples were collected from 205 patients with suspected urothelial neoplasms. The specificity and sensitivity of FISH were analyzed on the basis of pathological diagnosis. Result: One hundred and fifty-three patients with urothelial carcinoma and 52 cases of non-urothelial neoplasms received one FISH assay of their urine exfoliative cells before operation. The sensitivity of FISH examination of malignant epithelial tumor was 54.2%. The specificity of FISH on urothelial carcinoma was 94.2%.Conclusion: The FISH assay of the urine exfoliative cells shows high specificity for the detection of urothelial carcinoma.
- bladder cancer /
- fluorescence in situ hybridization /
- urothelial carcinoma

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参考文献(12)

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