PEDF在前列腺癌患者血清中的表达及临床意义

舒博; 陈鹏; 牛越; 张玲

PEDF在前列腺癌患者血清中的表达及临床意义

- 1. 新疆医科大学附属肿瘤医院泌尿科(乌鲁木齐, 830011);
- 2. 新疆维吾尔自治区疾病预防控制中心
基金项目:
新疆维吾尔自治区自然科学基金（编号2010211A29），中国博士后科学基金面上资助第45批项目（编号20090451516）

详细信息

通讯作者: 张玲,E-mail:zhangling2613884@163.com

中图分类号: R737.25

收稿日期: 2012-05-06

Evaluation of the expression of PEDF in blood serum of prostate cancer patients and its clinical significance

- 1. Department of Urology, Affiliated Tumor Hospital, Xinjiang Medical University, Urumqi, 830011, China;
- 2. Center for Disease Control and Prevention of Xinjiang Uygur Autonomous Region

More Information

Corresponding author: ZHANG Ling, E-mail: zhangling2613884@163.com

Received Date: 06 May 2012

摘要

摘要: 目的：探讨色素上皮衍生因子（pigmentary epithelium derived factor， PEDF）在前列腺癌患者血清中表达并探讨其临床意义。方法：应用免疫印迹（Western blotting）法检测前列腺癌转移（PCaM）患者、前列腺癌未转移（PCa）患者及良性前列腺增生（BPH）患者血清中PEDF表达情况，并通过统计学方法比较各组PEDF的表达差异。结果：PEDF在BPH组血清样本中高于PCa组（P<0.05），PEDF在PCa组的血清样本中也高于PCaM组（P<0.05）。结论：PEDF与前列腺癌的发生和转移相关，并可能在前列腺癌的进展中起重要作用，借助测定PEDF的表达可以协助前列腺癌的诊断和预后评估。
- 色素上皮衍生因子 /
- 前列腺癌 /
- 免疫印迹法
Abstract: Objective: To detect the expression of pigmentary epithelium derived factor (PEDF) in the blood serum of prostate cancer and evaluation its clinical significances. Method: Western blotting method was used to detect PEDF expression in prostate cancer patients with metastasis (PCaM), prostate cancer patients without metastasis (PCa) and benign prostatic hyperplasia patients(BPH). Result: PEDF was more highly expressed in the blood serum of BPH patients than PCa patients (P<0.05). PEDF was also more highly expressed in the blood serum of PCa patients than PCaM patients (P<0.05). Conclusion: PEDF are related to the malignant transformation and metastatis of prostate cancer. To detect the expression of PEDF may make for judging prostate cancer's diagnosis and prognosis.
- pigmentary epithelium derived factor /
- prostate cancer /
- Western blotting

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参考文献(9)

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