生殖股神经生殖支移位海绵体神经修复大鼠勃起功能的研究

沈洲; 庞自力; 武新超; 张龙; 徐玉节; 李兵

doi:10.13201/j.issn.1001-1420.2014.04.023

生殖股神经生殖支移位海绵体神经修复大鼠勃起功能的研究

- 华中科技大学同济医学院附属协和医院泌尿外科(武汉, 430022)
基金项目:
国家自然科学基金资助项目 (编号81371379)

详细信息

通讯作者: 李兵, E-mail:bingli@mail.hust.edu.cn

中图分类号: R698.1

收稿日期: 2013-12-05

Erectile function recovery by genital branch of genitofemoral nerve to cavernous nerve transfer in rats

- Department of Urology, Fifth People's Hospital of Shanghai, Fudan University, Shanghai, 200240, China

More Information

Corresponding author: LI Bing, E-mail: bingli@mail.hust.edu.cn

Received Date: 05 December 2013

摘要

摘要: 目的: 研究生殖股神经生殖支移位海绵体神经修复双侧海绵体神经损伤大鼠阴茎勃起功能的可行性。方法: 将24只成年雄性SD大鼠随机分为3组:神经移位组(双侧生殖股神经生殖支近端与海绵体神经远端行端端吻合)、神经损伤组(双侧海绵体神经离断)和假手术组,每组8只。术后1、3个月行交配试验检测大鼠勃起功能恢复情况,术后3个月电刺激海绵体神经或生殖股神经生殖支,比较各组大鼠阴茎海绵体内压(ICP)的变化。结果: 术后1个月交配试验观察到神经移位组与神经损伤组有插入行为的大鼠个数无明显差异,而3个月后神经移位组观察到75%(6/8)的大鼠有交配行为,明显高于神经损伤组(P<0.05)。电刺激神经移位组大鼠生殖股神经生殖支时,可引起ICP明显升高,与神经损伤组相比差异有统计学意义(P<0.05)。结论: 生殖股神经生殖支移位海绵体神经可修复双侧海绵体神经损伤大鼠的勃起功能。
- 生殖股神经 /
- 海绵体神经 /
- 神经移位 /
- 勃起功能
Abstract: Objective: To investigate the feasibility of erectile function recovery by genital branch of genitofemoral nerve to cavernous nerve transfer in rat models with bilateral cavernous nerve resection. Method: Twenty-four adult male Sprague-Dawley rats were randomly divided into three groups:the nerve transfer group underwent nerve anastomosis bilaterally between proximal stump of genital branch of genitofemoral nerve and distal stump of cavernous nerve; the nerve resection group underwent bilateral cavernous nerve resection; and the sham operation group. One and three months postoperatively, mating test was performed to determine the potency of erectile function, and then intracavernous pressure (ICP) was measured at three months after surgery by electrostimulating the cavernous nerve or genital branch of genitofemoral nerve. Result: One month postoperatively, there was no significant difference in number of animals intromission observed between nerve transfer group and nerve resection group. However, 75% animals in the nerve transfer group displayed intromission behaviors at three months intervals, which was obviously higher than that in the nerve resection group (P<0.05). The ICP was markedly increased by electrostimulating the genital branch of genitofemoral nerve in the rats of nerve transfer group, significantly different from that in nerve resection group (P<0.05). Conclusion: Genital branch of genitofemoral nerve to cavernous nerve transfer can restore erectile function in rat models with bilateral cavernous nerve resection.
- genitofemoral nerve /
- cavernous nerve /
- nerve transfer /
- erectile function

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