前列腺癌患者血清中锌、镉含量变化及其临床意义

陈谷泉; 吴乐军; 吴应虬; 朱建友

doi:10.13201/j.issn.1001-1420.2015.05.017

前列腺癌患者血清中锌、镉含量变化及其临床意义

- 乐清市第二人民医院外科(浙江乐清, 325608)

详细信息

通讯作者: 陈谷泉,E-mail:chenguquanyouxiang@163.com

中图分类号: R737.25

收稿日期: 2014-12-25

Content change of zinc and cadmium in serum of patients with prostate cancer and its clinical significance

- Department of Surgery, Second People Hospital of Yueqing, Yueqing, Zhejiang, 325608, China

More Information

Corresponding author: CHEN Guquan, E-mail: chenguquanyouxiang@163.com

Received Date: 25 December 2014

摘要

摘要: 目的：研究血清锌、镉与前列腺癌（PCa）的关系，以探讨其在PCa诊断及防治中的价值。方法：选择PCa患者85例（PCa组）和健康体检者90例（对照组），抽取外周静脉血4 ml，分离血清。采用原子吸收分光光度法测定血清中锌、镉含量。结果：PCa组血清锌为（63.92±19.10）μg/dl，显著低于对照组（103.61±32.43）μg/dl；而PCa组血清镉为（13.58±3.64）μg/dl，显著高于对照组（7.45±2.31）μg/dl （P<0.05）。PCa组血清锌与前列腺特异抗原（PSA）之间呈明显负相关（P<0.05），相关系数r=-0.74；血清镉与PSA之间呈明显正相关（P<0.05），相关系数r=0.65。结论：血清锌降低及血清镉升高可能与PCa的发生密切相关；检测血清锌、镉可能对PCa的早期诊断具有重要价值。
- 前列腺癌 /
- 锌 /
- 镉
Abstract: Objective: To investigate the relationship between serum zinc, cadmium and prostate cancer (PCa) in order to explore its value in diagnosis and prevention of PCa.Method: Totally 85 patients with PCa (PCa group) and 90 cases of healthy persons (control group) were selected. Each case was taken 4 ml peripheral venous blood and serum was separated. Zinc and cadmium concentrations were detected by atomic spectrophotometry.Result: The serum zinc concentration in PCa group was (63.92±19.10) μg/dl, which was significantly lower than in control group (103.61±32.43) μg/dl. However, the serum cadmium concentration in PCa group was (13.58±3.64) μg/dl, which was significantly higher than in control group (7.45±2.31) μg/dl (P<0.05). Serum zinc in PCa group was negatively correlated with prostate specific antigen (PSA) (P<0.05), the correlation coefficient r=-0.74; while serum cadmium in PCa group was positively correlated with PSA (P<0.05), the correlation coefficient r=0.65.Conclusion: The decrease of serum zinc and increase of serum cadmium may be closely related to the pathogenesis of PCa, and detection of serum zinc, cadmium may play an important role in early diagnosis of PCa.
- prostate cancer /
- zinc /
- cadmium

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参考文献(10)

[1]	陈孝平主编.外科学[M].第2版.北京:人民卫生出版社, 2010:850-851.
[2]	韩苏军, 张思维, 陈万青, 等.中国前列腺癌发病现状和流行趋势分析[J].临床肿瘤学杂志, 2013, 18(4):330-334.
[3]	Park S Y, Wilkens L R, Morris J S, et al.Serum zinc and prostate cancer risk in a nested case-control study:The multiethnic cohort[J].Prostate, 2013, 73(3):261-266.
[4]	Medarova Z, Ghosh S K, Vangel M, et al.Risk stratification of prostate cancer patients based on EPS-urine zinc content[J].Am J Cancer Res, 2014, 4(4):385-393.
[5]	Wong Y C, Wang Y Z, Lee J S, et al.Changes in serum and tissue zinc levels in sex hormone-induced prostatic carcinogenesis in the noble rat[J].Tumour Biol, 2000, 21(6):328-336.
[6]	Gao S, Hsieh C L, Zhou J, et al.Zinc Finger 280B regulates sGCα1 and p53 in prostate cancer cells[J].PLoS One, 2013, 8(11):e78766.
[7]	Hartwig A.Cadmium and cancer[J].Met Ions Life Sci, 2013, 11:491-507.
[8]	Julin B, Wolk A, Johansson J E, et al.Dietary cadmium exposure and prostate cancer incidence:apopulation-based prospective cohort study[J].Br J Cancer, 2012, 107(5):895-900.
[9]	李晓建, 潘东亮, 李宁忱, 等.重金属暴露与前列腺癌发生和进展的关系综述[J].环境化学, 2014, 33(10):1776-1783.
[10]	Zeng X, Jin T, Jiang X, et al.Effects on the prostate of environmental cadmium exposure——a cross-sectional population study in China[J].Biometals, 2004, 17(5):559-565.