昼夜节律与前列腺癌关系研究进展

陈骋; 马建; 申吉泓

doi:10.13201/j.issn.1001-1420.2015.05.026

昼夜节律与前列腺癌关系研究进展

- 昆明医科大学附属第一医院泌尿外科 (昆明, 650032)
基金项目:
云南省科技计划项目（编号2012FB042）

详细信息

通讯作者: 申吉泓,E-mail:chenchengdoc@sohu.com

中图分类号: R737.25

收稿日期: 2014-08-09

Research progress of relationship between circadian rhythm and prostate cancer

- Department of Urology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China

More Information

Corresponding author: SHEN Jihong, E-mail: chenchengdoc@sohu.com

Received Date: 09 August 2014

摘要

摘要: 昼夜节律普遍存在于各种生物体，参与多种生命活动。生活节奏的加快使人体昼夜节律的破坏日趋严重，进而导致一系列严重疾病。前列腺癌（PCa）的发病率位居男性恶性肿瘤前列，但其发病机制仍不明确。近年来的多项研究发现昼夜节律紊乱与PCa等多种肿瘤发生相关。本文就昼夜节律与PCa的关系进行综述。
- 昼夜节律 /
- 前列腺癌 /
- 肿瘤发生
Abstract: Circadian rhythm generally exists and participates in many activities of life in various organisms. An accelerating rhythm of living destructed human circadian rhythm seriously and led to a series of serious diseases. The incidence of prostate cancer is high in male patients with malignant tumors, but its pathogenesis has not been elucidated. Recent studies show circadian rhythm dysregulation plays a possible role in tumorigenesis of prostate cancer and other tumors. The relationship between circadian rhythm and prostate cancer tumorigenesis has been summarized in this article.
- circadian rhythm /
- prostate cancer /
- tumorigenesis

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参考文献(32)

[1]	Rebecca S, Jiemin M, Zhaohui Z, et al.Cancer Statistics, 2014[J].Ca Cancer J Clin, 2014, 64:9-29.
[2]	Kelleher F C, Rao A, Maguire A.Circadian molecular clocks and cancer[J].Cancer Lett, 2014, 342(1):9-18.
[3]	Markt S C, Valdimarsdottir U A, Shui I M, et al.Circadian clock genes and risk of fatal prostate cancer[J].Cancer Causes Control, 2015, 26(1):25-33.
[4]	Lee J H, Sancar A.Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis[J].PNAS, 2011, 108:10668-10672.
[5]	Lee E, Salic A, Kirschner M W.Physiological regulation of[beta] -catenin stability by Tcf3and CK1epsilon[J].J Cell Biol, 2001, 154:983-993.
[6]	Zhu Y, Stevens R G, Hoffman A E, et al.Testing the circadian gene hypothesis in prostate cancer:apopulation-based case-control study[J].Cancer Res, 2009, 69(24):9315-9322.
[7]	Ortiz-Tudela E, Mteyrek A, Ballesta A, et al.Cancer chronotherapeutics:experimental, theoretical, and clinical aspects[J].Handb Exp Pharmacol, 2013, (217):261-288.
[8]	Gorbacheva V Y, Kondratov R V, Zhang R, et al.Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMALI transactivation complex[J].PNAS, 2005, 102(9):3407-3412.
[9]	Kubo T, Oyama I, Nakamura T, et al.Industry-based retrospective cohort study of the risk of prostate cancer among rotating-shift workers[J].Int J Urol, 2011, 18(3):206-211.
[10]	Papantoniou K, Castano-Vinyals G, Espinosa A, et al.Night shift work, chronotype and prostate cancer risk in the MCC-Spain case-control study[J].Int J Cancer, 2015, 1(ePublish ahead)
[11]	Conlon M, Lightfoot N, Kreiger N.Rotating shift work and risk of prostate cancer[J].Epidemiology, 2007, 18:182-183.
[12]	Pukkala E, Aspholm R, Auvinen A, et al.Cancer incidence among 10, 211airline pilots:a Nordic study[J].Aviat Space Environ Med, 2003, 74:699-706.
[13]	Pukkala E, Ojamo M, Rudanko S L, et al.Does incidence of breast cancer and prostate cancer decrease with increasing degree of visual impairment[J].Cancer Causes Control, 2006, 17:573-576.
[14]	Obretan K, Impey S, Smith D, et al.circadian regulation of cAMP response element-mediated gene expression in the suprachiasmatic nuclei[J].J Biol Chem, 1999, 274(25):17748-17756.
[15]	Doig C L, Singh P K, Dhiman V K, et al.Thorne recruitment of ncor1to vdr target genes is enhanced in prostate cancer cells and associates with altered dna methylation patterns[J].Carcinogenesis, 2013, 34(2):248-256.
[16]	姜熙, 曹志刚, 戚敏俊, 等.南京地区汉族人群VDR基因多态性与前列腺癌易感性的关系研究[J].中华男科学杂志, 2013, 19(10):953-955.
[17]	Jung-Hynes B, Schmit T L, Reagan-Shaw S R, et al.Melatonin, a novel sirt1inhibitor, imparts antiproliferative effects against prostate cancer in vitro in culture and in vivo in tramp model[J].J Pineal Res, 2011, 50(2):140-149.
[18]	Brittney J H, Wei H, Russel J, et al.Melatonin resynchronizes dysregulated circadian rhythm circuitry in human prostate cancer cells[J].J Pineal Res, 2010, 49(1):60-68.
[19]	徐丽, 金清东, 宫喜, 等.褪黑素对小鼠胃癌的抑制作用及Bcl-2, Bax, p21, p53表达变化研究[J].生理学报, 2014, 66(6):723-729.
[20]	Proietti S, Cucina A, Dobrowolny G, et al.Melatonin down-regulates MDM2 gene expression and enhances p53acetylation in MCF-7cells[J].J Pineal Res, 2014, 57(1):120-129.
[21]	Nguyen H L, Zucker S, Zarrabi K, et al.Oxidative stress and prostate cancer progression are elicited by membrane-type 1 matrix metalloproteinase[J].Mol Cancer Res, 2011, 9(10):1305-1318.
[22]	Qi C, Sigal G, Azadeh D, et al.A role for the clock gene per1in prostate cancer[J].Cancer Res, 2009, 69:7619-7625.
[23]	Comstock C E, Augello M A, Schiewer M J, et al.Cyclin d1is a selective modifier of androgen-dependent signaling and androgen receptor function[J].J Biol Chem, 2011, 286(10):8117-8127.
[24]	Lim J T, Mansukhani M, Weinstein I B.Cyclin-dependent kinase 6associates with the androgen receptor and enhances its transcriptional activity in prostate cancer cells[J].Proc Natl Acad Sci USA, 2005, 102:5156-5161.
[25]	Chu L W, Zhu Y, Yu K, et al.Correlation between circadian gene variants and serum levels of sex steroids and insulin-like growth factor-1[J].Cancer Epidemiol Biomarkers Prev, 2008, 17:3268-3273.
[26]	Wittert G.The relationship between sleep disorders and testosterone in men[J].Asian J Androl.2014V16N2:262-265.
[27]	Dehm S M, Tindall D J.Molecular regulation of androgen action in prostate cancer[J].J Cell Biochem, 2006, 99:333-344.
[28]	Banez L L, Albisinni S, Freedland S J, et al.The impact of obesity on the predictive accuracy of PSA in men undergoing prostate biopsy[J].World J Urol, 2014, 32(2):323-328.
[29]	Ohlsson C, Wallaschofski H, Lunetta K L, et al.Genetic determinants of serum testosterone concentrations in men[J].PLoS Genet, 2011, 7(10):e1002313.
[30]	Jin G, Sun J, Kim S T, et al.Genome-wide association study identifies a new locus jmjd1cat 10q21that may influence serum androgen levels in men[J].Hum MolGenet, 2012, 21(23):5222-5228.
[31]	Platica M, Ionescu A, Ivan E, et al.PAR, aprotein involved in the cell cycle, is functionally related to chromosomal passenger proteins[J].Int J Oncol, 2011, 38(3):777-785.
[32]	Lange E M, Johnson A M, Wang Y, et al.Genomewide association scan for variants associated with earlyonset prostate cancer[J].PLoS One, 2014, 9(4):e93436.