钙化性纳米微粒与泌尿系疾病相关性研究的新进展

康云鹏; 武进峰

doi:10.13201/j.issn.1001-1420.2015.05.028

钙化性纳米微粒与泌尿系疾病相关性研究的新进展

康云鹏¹,
武进峰^2, ,

- 1. 山西医科大学(太原, 030001);
- 2. 山西医科大学山西大医院泌尿外科

详细信息

通讯作者: 武进峰,E-mail:wujf005@126.com

中图分类号: R692.4

收稿日期: 2014-11-22

Latest progress of correlative studies between calcifying nanoparticles and urinary system diseases

KANG Yunpeng¹,
WU Jinfeng^2, ,

- 1. Shanxi Medical University, Taiyuan, 030001, China;
- 2. Department of Urology, Shanxi Dayi Hospital of Shanxi Medical University

More Information

Corresponding author: WU Jinfeng, E-mail: wujf005@126.com

Received Date: 22 November 2014

摘要

摘要: 钙化性纳米颗粒（CNPs）是一种磷酸钙和蛋白质共同形成的纳米大小的球形复合物，具有自我复制的功能，曾被称为"纳米细菌"。然而在其被发现27年后，它们的性质仍未完全确定，到目前为止，没有人能够确定它们是否是地球上最小的能够自我复制的生命形式，抑或简单的蛋白质-矿物质组合体。同时，由于这些生物体主要从泌尿生殖道被分离出来，因此，越来越多的研究关注了这种颗粒在泌尿系统疾病病因学中所发挥的作用，包括肾结石、多囊肾以及慢性Ⅲ型前列腺炎（慢性盆腔疼痛综合征）。本文综述了钙化性纳米微粒的当前研究现状，并探索这些粒子如何影响泌尿系疾病。
- 钙化性纳米微粒 /
- 肾结石 /
- 慢性前列腺炎
Abstract: Calcifying nanoparticles (CNPs) appearing as self-propagating nano-sized complexes of calcium phosphate mineral and proteins, has been called the "nanobacteria". Though they were discovered 27 years ago, their nature is still obscure. Up to now nobody has been successful in credibly determining whether they are the smallest self-replicating life form on Earth, or mineralo-protein complexes. These nanoparticles isolated mainly from urogenital tract, so more and more studies show the significant role of CNPs in the etiopathogenesis of urinary system diseases including nephrolithiasis, polycystic kidney disease and type Ⅲ chronic prostatitis (chronic pelvic pain syndrome). This paper reviews the current research situation of CNPs, and explore how these particles affect the urinary system diseases.
- calcifying nanoparticles /
- nephrolithiasis /
- chronic prostatitis

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