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摘要: 泌尿系结石是泌尿外科常见疾病。近年来,我国泌尿系结石的发病率有逐渐增加的趋势,对于结石的病因与发病机制的认识也经历了一个很长的过程,但仍然无法得出一个完整的定论。20世纪90年代后,纳米细菌的发现使人们对于泌尿系结石的形成过程有了新的认识。但纳米细菌是否作为一个真实的生命体,以及如何导致相关疾病的发生等方面仍存在很大的争议。本文旨在介绍纳米细菌的本质及其独特的生物作用,综述纳米细菌近年来的研究进展,讨论纳米细菌作为泌尿系结石的发病因素在临床上的应用并作出展望。Abstract: Urinary calculus is the common disease in urology. In recent years, the incidence of urinary calculi in our country gradually increases. The understanding of the etiology and pathogenesis of stone also has experienced a long process, but we still can't draw a valid conclusion. Since the 1990s, the discovery of nanobacteria has made people have a new understanding of the formation process of urinary calculi. However, whether the nanobacteria are real lives, or how they lead to the occurrence of related diseases is still controversial. This article is to introduce the nature and unique biological role of nanobacteria, review the research progress of nanobacteria in recent years, discuss the application of nanobacteria as urinary calculi incidence factors in clinic and open up a bright prospect.
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Key words:
- urinary calculi /
- nanobacteria /
- 16srRNA /
- Fetuin-A /
- biomineralization
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