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摘要: 膀胱肿瘤是泌尿系统常见肿瘤之一,根据肿瘤浸润深度分为肌层浸润性膀胱癌和非肌层浸润性膀胱癌,肌层浸润性膀胱癌约占15%~25%。根治性膀胱切除术加盆腔淋巴结清扫术是肌层浸润性膀胱癌的标准治疗方式。但该手术存在并发症发生率高、严重影响生活质量等问题。近年来,随着技术水平的发展,肌层浸润性膀胱癌保留膀胱的治疗方式逐渐得到了学者们的重视与应用。本文就肌层浸润性膀胱癌保留膀胱的手术治疗进展进行一综述。Abstract: Bladder cancer is one of the common cancers of the urinary system.It can be divided into muscle invasive bladder cancer (MIBC) and non-muscle invasive bladder cancer according to the depth of tumor invasion, and MIBC accounts for 15%-25% of all cases.Radical cystectomy (RC) with pelvic lymph node dissection remains the gold-standard treatment for MIBC.However, RC shows a high incidence of complications which has corresponding effects on quality of life.In recent years, bladder-sparing techniques for MIBC has been widely accepted and applied.This paper summarized the progress of bladder-sparing surgical treatment for MIBC.
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Key words:
- bladder cancer /
- bladder-sparing surgical treatment /
- radical cystectomy
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[1] Siegel R L, Miller K D, Jemal A.Cancer statistics, 2016[J].CA Cancer J Clin, 2016, 66 (1):7-30.
[2] Chen W, Zheng R, Baade P D, et al.Cancer statistics in China, 2015[J].CA Cancer J Clin, 2016, 66 (2):115-132.
[3] Ro J Y, Staerkel G A, Ayala A G.Cytologic and histologic features of superficial bladder cancer[J].Urol Clin North Am, 1992, 19 (3):435-453.
[4] Nowak-Sadzikowska J, Skóra T, Szyszka-Charewicz B, et al.Muscle-invasive bladder cancer treated with TURB followed by concomitant boost with small reduction of radiotherapy field with or without of chemotherapy[J].Rep Pract Oncol Radiother, 2016, 21 (1):31-36.
[5] Grob B M, Macchia R J.Radical transurethral resection in the management of muscle-invasive bladder cancer[J].J Endourol, 2001, 15 (4):419-423.
[6] Volkmer B G, Kuefer R, Bartsch G Jr, et al.Effect of a pT0 cystectomy specimen without neoadjuvant therapy on survival[J].Cancer, 2005, 104 (11):2384-2391.
[7] Solsona E, Iborra I, Ricós J V, et al.Feasibility of transurethral resection for muscle infiltrating carcinoma of the bladder:long-term followup of a prospective study[J].J Urol, 1992, 147 (6):1513-1515.
[8] El-Taji O M, Alam S, Hussain S A.Bladder sparing approaches for muscle-invasive bladder cancers[J].Curr Treat Options Oncol, 2016, 17 (3):15.
[9] Herr H W.Transurethral resection of muscle-invasive bladder cancer:10-year outcome[J].J Clin Oncol, 2001, 19 (1):89-93.
[10] Solsona E, Iborra I, Collado A, et al.Feasibility of radical transurethral resection as monotherapy for selected patients with muscle invasive bladder cancer[J].J Urol, 2010, 184 (2):475-480.
[11] Han B, Liang S, Jing Y, et al.Organ preservation for muscle-invasive bladder cancer by preoperative intra-arterial chemotherapy and transurethral resection[J].Med Oncol, 2014, 31 (4):912.
[12] 张国辉, 王金萍, 郑清友, 等.肌层浸润性膀胱癌保留膀胱手术后不同辅助治疗方法的疗效评价[J].现代泌尿外科杂志, 2013, 18 (6):557-561.
[13] Tunio M A, Hashmi A, Rafi M, et al.Bladder preservation by neoadjuvant chemotherapy followed by concurrent chemoradiation for muscle-invasive bladder cancer:experience at Sindh Institute of Urology &Transplantation (SIUT)[J].J Pak Med Assoc, 2011, 61 (1):6-10.
[14] Pieters B R, Blank L E C M, Koedooder C, et al. External beam radiotherapy combined with brachytherapy for muscle-invasive bladder cancer results in good local control and bladder sparing outcome in a cohort of 1040patients[J].Eur Urol Suppl, 2012, 11 (5):183.
[15] Bamias A, Tsantoulis P, Zilli T, et al.Outcome of patients with nonmetastatic muscle-invasive bladder cancer not undergoing cystectomy after treatment with noncisplatin-based chemotherapy and/or radiotherapy:a retrospective analysis[J].Cancer Med, 2016, 5 (6):1098-1107.
[16] Arcangeli G, Strigari L, Arcangeli S.Radical cystectomy versus organ-sparing trimodality treatment in muscleinvasive bladder cancer:A systematic review of clinical trials[J].Crit Rev Oncol Hematol, 2015, 95 (3):387-396.
[17] Gerardi M A, Jereczek-Fossa B A, Zerini D, et al.Bladder preservation in non-metastatic muscle-invasive bladder cancer (MIBC):a single-institution experience[J].Ecancermedicalscience, 2016, 10:657.
[18] Babjuk M, Oosterlinck W, Sylvester R, et al.EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder[J].Eur Urol, 2008, 54 (2):303-314.
[19] Divrik R T, 爦ahin A F, Yildirim, et al.Impact of routine second transurethral resection on the long-term outcome of patients with newly diagnosed pT1 urothelial carcinoma with respect to recurrence, progression rate, and disease-specific survival:aprospective randomised clinical trial[J].Eur Urol, 2010, 58 (2):185-190.
[20] Daneshmand S.The value of extended transurethral resection of bladder tumour (TURBT) in the treatment of bladder cancer[J].BJU Int, 2012, 110 (2Pt 2):E80.
[21] Suer E, Hamidi N, Gokce M I, et al.Significance of second transurethral resection on patient outcomes in muscle-invasive bladder cancer patients treated with bladder-preserving multimodal therapy[J].World J Urol, 2015, 34 (6):847-851.
[22] Schoborg T W, Sapolsky J L, Lewis C W Jr.Carcinoma of the bladder treated by segmental resection[J].J Urol, 1979, 122 (4):473-475.
[23] Smith Z L, Christodouleas J P, Keefe S M, et al.Bladder preservation in the treatment of muscle-invasive bladder cancer (MIBC):a review of the literature and a practical approach to therapy[J].BJU Int, 2013, 112 (1):13-25.
[24] Fujii Y, Kihara K, Tanaka H, et al.Mp65-04oncological and functional outcomes in muscle-invasive bladder cancer patients undergoing bladder-sparing treatment consisting of low-dose chemoradiotherapy and consolidative partial cystectomy[J].J Urol, 2015, 193 (4):e808-e808.
[25] Knoedler J, Kim S, Boorjian S, et al.1409does partial cystectomy compromise oncologic outcomes for patients with invasive bladder cancer compared to radical cystectomy?A matched, case-control analysis[J].J Urol, 2012, 187 (4):e572.
[26] Knoedler J, Frank I.Organ-sparing surgery in urology:partial cystectomy[J].Curr Opin Urol, 2015, 25 (2):111-115.
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