精子DNA碎片及其在不育症诊治中的应用

张俊峰; 彭炜; 王涛; 刘继红

doi:10.13201/j.issn.1001-1420.2018.08.019

精子DNA碎片及其在不育症诊治中的应用

- 1. 华中科技大学同济医学院附属同济医院泌尿外科(武汉, 430030);
- 2. 湖北省泌尿外科研究所

详细信息

通讯作者: 王涛,E-mail:tjhwt@126.com

中图分类号: R698.2

收稿日期: 2017-05-24

Sperm DNA fragmentation and its application in the diagnosis and treatment of infertility

- 1. Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China;
- 2. Hubei Institute of Urology

More Information

Corresponding author: WANG Tao, E-mail: tjhwt@126.com

Received Date: 24 May 2017

摘要

摘要: 精子DNA碎片(SDF)是近年来国内外生殖医学领域研究的热点,随着大量实验研究和临床研究的开展,SDF对于男性生殖能力具有重大影响已成为学术界的共识。但是,SDF产生机制不明确,治疗手段也较为有限,同时关于SDF的众多问题仍然存在较大争议,本文从SDF的产生机制、临床意义、检测方法和治疗手段4个方面对SDF的发展及应用现状予以综述,以利于对SDF进一步的深入研究。
- 精子DNA碎片 /
- 产生机制 /
- 临床意义 /
- 检测方法 /
- 治疗手段
Abstract: Sperm DNA fragmentation is a hot spot in the field of reproductive medicine at home and abroad recently.With the development of a large number of experimental studies and clinical researches, the significant impact of the SDF on male reproductive ability has become the consensus of academia.Nonetheless, there are many controversial issues on the SDF.Its exact mechanism is unclear, and its effective cure methods are comparatively limited.In this paper, we reviewed basic experiments and clinical trials to contribute to its in-depth studies from four aspects the generation mechanism of SDF, clinical significances, detection methods and treatment methods.
- sperm DNA fragmentation /
- mechanism theory /
- clinical significance /
- detection method /
- treatment method

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