Advances in research on the mechanism of action of reactive oxygen species in the formation of calcium oxalate kidney stones
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摘要: 肾结石的成分繁多、成因复杂,其形成过程一直都是研究者们亟于攻克的领域。随着草酸钙肾结石形成研究的逐步深入,活性氧(ROS)影响草酸钙肾结石形成的部分机制也开始变得明确。本文主要就草酸及草酸钙晶体如何介导形成ROS以及其在草酸钙肾结石形成及防治中相关机制的基础研究作一综述。Abstract: Kidney stones have many components and complex causes, and their formation process has always been a field that researchers are tempted to overcome. With the gradual deepening of the research on the formation of calcium oxalate kidney stones, some of the mechanisms by which reactive oxygen species(ROS) affect the formation of calcium oxalate kidney stones have begun to become clear. This article reviews the basic research on how oxalic acid and calcium oxalate crystals mediate ROS formation and its related mechanisms in the formation and prevention of calcium oxalate kidney stones.
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