降钙素原动态变化对经直肠前列腺穿刺活检后抗生素应用的指导价值

胡斌; 路玫; 韦秀望; 廖君娟; 韦华玉

doi:10.13201/j.issn.1001-1420.2019.10.014

降钙素原动态变化对经直肠前列腺穿刺活检后抗生素应用的指导价值

- 1. 广西壮族自治区人民医院泌尿外科(南宁, 530021);
- 2. 广西壮族自治区人民医院临床药学科
基金项目:
广西壮族自治区卫生和计划生育委员会自筹经费科研课题（编号Z20170321）

详细信息

通讯作者: 路玫,E-mail:Lumei951219@163.com

中图分类号: R737.25

收稿日期: 2018-11-28

Guiding value of dynamic change of procalcitonin for antibiotics application after transrectal prostatic biopsy

- 1. Department of Urology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021, China;
- 2. Department of Clinical Medicine, People's Hospital of Guangxi Zhuang Autonomous Region

More Information

Corresponding author: LU Mei, E-mail: Lumei951219@163.com

Received Date: 28 November 2018

摘要

摘要: 目的：探讨降钙素原（PCT）动态变化对经直肠前列腺穿刺活检后抗生素应用的指导价值。方法：前列腺穿刺活检术患者129例为研究对象，其中59例为对照组，术后常规使用3 d抗生素，根据病情变化调整抗生素的应用；另外70例为试验组，检测所有患者术前2 h、术后36 h、3 d及7 d血清PCT水平，试验组依据PCT变化调整抗生素应用。记录两组的抗生素应用时间、抗生素费用、穿刺感染及感染性休克。结果：对照组和试验组术前2 h、术后36 h、3 d血清PCT比较差异无统计学意义（P>0.05），对照组术后7 d血清PCT明显高于试验组，差异有统计学意义（P<0.05）。对照组和试验组的抗生素应用时间、抗生素费用、穿刺感染率比较差异均有统计学意义（P<0.05）。结论：经直肠前列腺穿刺活检后动态监测血清PCT水平，可以指导抗生素的应用，减少抗生素应用时间、抗生素费用及穿刺感染率。
- 经直肠前列腺穿刺活检 /
- 抗生素 /
- 感染率
Abstract: Objective: To investigate the guiding value of dynamic change of procalcitonin(PCT) for antibiotics application after transrectal prostatic biopsy. Method: One hundred and twenty-nine cases undergoing transrectal prostatic biopsy were taken as the research objects. Among them, 59 cases were taken as control group and received routine treatment, antibiotics for 3 days after surgery, then the application of antibiotics was adjusted according to the condition changes. Another 70 cases as experimental group. The level of serum PCT was detected 2 h before operation, 36 h, 3 d and 7 d after operation of all patients. Experimental group were adjusted antibiotics according to change of PCT. Antibiotics application time, cost of antibiotics and puncture infection and septic shock were recorded in the two groups. Result: There was no statistically significant difference of serum PCT levels 2 h before operation, 36 h, 3 d after operation(P>0.05). Serum PCT level 7 h after operation of experiment group was lower than that of the control group 7 d postoperatively. The difference of antibiotics application time, cost of antibiotics, puncture infection rate were statistically significant(P<0.05).Conclusion: Serum PCT dynamic level detection could be used for guiding antibiotics application and reduce antibiotics application time, cost of antibiotics, puncture infection rate.
- transrectal prostatic biopsy /
- antibiotics /
- infection rate

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