间充质干细胞来源的细胞外囊泡与肾损伤修复

王琪; 姜大朋

doi:10.13201/j.issn.1001-1420.2020.03.016

间充质干细胞来源的细胞外囊泡与肾损伤修复

王琪,
姜大朋^,

- 上海交通大学医学院附属上海儿童医学中心小儿泌尿外科(上海, 200120)
基金项目:
国家自然科学基金项目(No:81472085)

详细信息

通讯作者: 姜大朋,E-mail:jdp509@163.com

中图分类号: R692

收稿日期: 2019-03-23

Mesenchymal stem cell-derived extracellular vesicles for kidney repair

WANG Qi,
JIANG Dapeng^,

- Department of Pediatric Urology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200120, China

More Information

Corresponding author: JIANG Dapeng, E-mail: jdp509@163.com

Received Date: 23 March 2019

摘要

摘要: 间充质干细胞(mesenchymal stem cell,MSC)具有修复、再生和免疫调节功能,其在器官损伤修复过程中发挥重要作用。MSC的治疗机制与其旁分泌形成的细胞外囊泡(extracellular vesicles,EVs)有关。EVs主要包括外泌体(exosome)和微囊泡(microvesicles),其内含多种遗传物质和蛋白信号分子,这些成分在调控细胞间信号传递中起重要作用,可影响受体细胞的增殖、分化、凋亡。肾脏疾病的治疗效果并不理想,因此迫切需要寻找新的有效治疗手段,目前的研究已提示EVs与肾脏损伤与修复密切相关。本文将对MSC来源EVs对肾脏损伤修复的作用及其机制进行综述。
- 间充质干细胞 /
- 细胞外囊泡 /
- 外泌体 /
- 急性肾损伤 /
- 慢性肾病
Abstract: Mesenchymal stem cell(MSC)have the function of repair,regeneration and immunomodulation,which play an important role in the repair of organ injury.The therapeutic effects of MSC are primarily mediated by the paracrine release of factors,including extracellular vesicles(EVs),composed of microvesicles and exosomes.MSC-derived EVs contain a variety of genetic and protein material that play a key role in the intercellularcommunication,and can affect the proliferation,differentiation and apoptosis of receptor cells.Treatment of kidney diseases is not satisfactory,so it is urgent to find new and effective treatments.Current researches have revealed that EVs are closely related to renal injury and repair.In this review,we summarized the application and mechanism of MSC-derived EVs in the repair of kidney injury.
- mesenchymal stem cell /
- extracellular vesicles /
- exosomes /
- acute kidney injury /
- chronic kidney disease

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