HIF-1α表达对膀胱尿路上皮癌预后的影响

邓光程, 张新明, 黄智超, 等. HIF-1α表达对膀胱尿路上皮癌预后的影响[J]. 临床泌尿外科杂志, 2020, 35(8): 624-630,634. doi: 10.13201/j.issn.1001-1420.2020.08.007
引用本文: 邓光程, 张新明, 黄智超, 等. HIF-1α表达对膀胱尿路上皮癌预后的影响[J]. 临床泌尿外科杂志, 2020, 35(8): 624-630,634. doi: 10.13201/j.issn.1001-1420.2020.08.007
DENG Guangcheng, ZHANG Xinming, HUANG Zhichao, et al. Effects of hypoxia-inducible factor-1α expression on prognosis of human bladder urothelial carcinoma[J]. J Clin Urol, 2020, 35(8): 624-630,634. doi: 10.13201/j.issn.1001-1420.2020.08.007
Citation: DENG Guangcheng, ZHANG Xinming, HUANG Zhichao, et al. Effects of hypoxia-inducible factor-1α expression on prognosis of human bladder urothelial carcinoma[J]. J Clin Urol, 2020, 35(8): 624-630,634. doi: 10.13201/j.issn.1001-1420.2020.08.007

HIF-1α表达对膀胱尿路上皮癌预后的影响

  • 基金项目:

    湖南省科学技术厅科技计划项目(No:2013SK3047)

详细信息
    通讯作者: 吴洪涛,E-mail:wht168@csu.edu.cn
  • 中图分类号: R737.14

Effects of hypoxia-inducible factor-1α expression on prognosis of human bladder urothelial carcinoma

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  • 目的:探讨缺氧诱导因子-1α(hypoxia inducible factor-1α,HIF-1α)在膀胱尿路上皮癌(bladder urothelial carcinoma,BUC)中的表达及其与膀胱尿路上皮癌预后的影响。方法:回顾性分析90例手术治疗的膀胱尿路上皮癌患者的临床病理资料,采用免疫组化的方法检测切除标本中HIF-1α的表达情况,Kaplan-Meier法对HIF-1α的表达,血红蛋白含量及吸烟史等变量进行分析,建立Cox比例风险回归模型分析多变量的影响。结果:90例研究对象年龄51~88岁,平均(68.2±9.4)岁,血红蛋白含量75~145 g/L,平均(109.5±13.9)g/L。所有患者均随访5年,中位总生存期为34.0个月,中位无病生存期14.5个月。不同水平HIF-1α表达组之间临床病理分期、组织学分级、吸烟史和血红蛋白水平比较差异有统计学意义(P<0.05)。HIF-1α的表达水平与临床病理分期及组织学分级均正相关(P<0.001)。HIF-1α的表达水平越高,其总生存期(overall survival,OS)及无病生存期(disease-free survival,DFS)越短,差异有统计学意义(P<0.05)。Cox比例风险回归模型中,HIF-1α的表达水平是影响OS及DFS的独立因素(P<0.05),血红蛋白水平是影响DFS的独立因素(P<0.05)。结论:HIF-1α的表达水平是膀胱尿路上皮癌的独立预后因素,且与膀胱尿路上皮癌的预后呈负相关。
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出版历程
收稿日期:  2019-11-23

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