Study on brain functional networks related to micturition control in healthy adults based on magnetic resonance imaging
-
摘要: 目的:研究健康成人因强烈排尿感而引起的与排尿控制相关的脑功能网络的改变。方法:选择年龄25~50岁健康受试者43例(男20例,女23例),均为右利手。分别在膀胱空虚和强烈排尿感状态进行两次静息态功能性核磁共振成像(rs-fMRI)扫描。使用自动解剖标记(AAL)图谱将大脑皮层和皮层下结构分割为90个脑区,并计算90个脑区之间的Pearson相关系数,即功能连接(FC),构建2种状态下的脑功能网络,使用配对样本t检验(P＜0.05,FDR校正后)来检测2种状态下脑区间FC差异的显著性。结果:与膀胱空虚状态相比,强烈排尿感状态默认网络(DMN)内的FC显著增强(P＜0.05,FDR校正后)。结论:健康成人的排尿控制过程不是由某一大脑区域单独完成的,而是一个主要由DMN参与的过程,这可以作为膀胱功能障碍潜在的病理过程的基线,有利于促进大脑靶向疗法的出现。Abstract: Objective: To study the changes of brain functional networks related to the control of micturition in healthy adults due to the strong desire to void.Methods: Forty-three healthy subjects aged 25 to 50(20 males and 23 females) were screened, and all of them were right-handed. Two rest state-functional magnetic resonance imaging scans were performed under an empty bladder and a strong desire to void states. The cerebral cortex and subcortical structures were divided into 90 brain regions using automated anatomical labeling atlas, and the Pearson's correlation coefficient among the 90 brain regions, namely functional connectivity(FC), was calculated to construct the brain functional network in the two states. A paired t test [P＜0.05, after false discovery rate(FDR) correction] was used to detect the significance of FC difference between the two states.Results: Compared with the empty bladder state, the FC within the default mode network(DMN) of strong desire to void state significantly increased.Conclusion: We suggest that control of micturition in healthy adults should not be performed by an individual brain region, but by a complex process dominated by DMN, which can serve as a baseline for underlying the pathologic processes of bladder dysfunction and facilitate the emergence of brain-targeted therapies.
-
Key words:
- functional connectivity /
- brain-bladder control /
- void /
- strong desire to void /
- central mechanism
-
-
[1] Griffiths D.Neural control of micturition in humans:a working model[J].Nat Rev Urol,2015,12(12):695-705.
[2] Griffiths D,Tadic SD.Bladder control,urgency,and urge incontinence:evidence from functional brain imaging[J].Neurourol Urodyn,2008,27(6):466-474.
[3] Zuo L,Zhou Y,Wang S,et al.Abnormal Brain Functional Connectivity Strength in the Overactive Bladder Syndrome:A Resting-State fMRI Study[J].Urology,2019,131:64-70.
[4] Ketai LH,Komesu YM,Dodd AB,et al.Urgency urinary incontinence and the interoceptive network:a functional magnetic resonance imaging study[J].Am J Obstet Gynecol,2016,215(4):449.e1-449.e17.
[5] Jin M,Wang L,Wang H,et al.Altered resting-state functional networks in patients with hemodialysis:a graph-theoretical based study[J].Brain Imaging Behav,2021,15(2):833-845.
[6] Tzourio-Mazoyer N,Landeau B,Papathanassiou D,et al.Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain[J].Neuroimage,2002,15(1):273-289.
[7] Raichle ME.The brain's default mode network[J].Annu Rev Neurosci,2015,38:433-447.
[8] Harrison BJ,Pujol J,López-Solà M,et al.Consistency and functional specialization in the default mode brain network[J].Proc Natl Acad Sci U S A,2008,105(28):9781-9786.
[9] Bonnici HM,Cheke LG,Green D,et al.Specifying a Causal Role for Angular Gyrus in Autobiographical Memory[J].J Neurosci,2018,38(49):10438-10443.
[10] Jarrahi B,Mantini D,Mehnert U,et al.Exploring influence of subliminal interoception on whole-brain functional network connectivity dynamics[J].Annu Int Conf IEEE Eng Med Biol Soc,2015,2015:670-674.
[11] Nardos R,Karstens L,Carpenter S,et al.Abnormal functional connectivity in women with urgency urinary incontinence:Can we predict disease presence and severity in individual women using Rs-fcMRI/[J].Neurourol Urodyn,2016,35(5):564-573.
[12] Nardos R,Gregory WT,Krisky C,et al.Examining mechanisms of brain control of bladder function with resting state functional connectivity MRI[J].Neurourol Urodyn,2014,33(5):493-501.
[13] Cameron OG.Interoception:the inside story--a model for psychosomatic processes[J].Psychosom Med,2001,63(5):697-710.
[14] Nour S,Svarer C,Kristensen JK,et al.Cerebral activation during micturition in normal men[J].Brain,2000,123(Pt 4):781-789.
[15] Kuhtz-Buschbeck JP,van der Horst C,Pott C,et al.Cortical representation of the urge to void:a functional magnetic resonance imaging study[J].J Urol,2005,174(4 Pt 1):1477-1481.
[16] Athwal BS,Berkley KJ,Hussain I,et al.Brain responses to changes in bladder volume and urge to void in healthy men[J].Brain,2001,124(Pt 2):369-377.
[17] Sakakibara R,Fowler CJ,Hattori T.Voiding and MRI analysis of the brain[J].Int Urogynecol J Pelvic Floor Dysfunct,1999,10(3):192-199.
[18] Griffiths D,Derbyshire S,Stenger A,et al.Brain control of normal and overactive bladder[J].J Urol,2005,174(5):1862-1867.
[19] Blok BF.Central pathways controlling micturition and urinary continence[J].Urology,2002,59(5 Suppl 1):13-17.
[20] Leech R,Braga R,Sharp DJ.Echoes of the brain within the posterior cingulate cortex[J].J Neurosci,2012,32(1):215-222.
[21] Hardy SG,Leichnetz GR.Cortical projections to the periaqueductal gray in the monkey:a retrograde and orthograde horseradish peroxidase study[J].Neurosci Lett,1981,22(2):97-101.
[22] Gjone R.Excitatory and inhibitory bladder responses to stimulation of 'limbic',diencephalic and mesencephalic structures in the cat[J].Acta Physiol Scand,1966,66(1):91-102.
[23] Andrew J,Nathan PW.Lesions on the anterior frontal lobes and disturbances of micturition and defaecation[J].Brain,1964,87:233-262.
[24] van Kemenade BM,Arikan BE,Kircher T,et al.The angular gyrus is a supramodal comparator area in action-outcome monitoring[J].Brain Struct Funct,2017,222(8):3691-3703.
[25] Laird AR,Eickhoff SB,Li K,et al.Investigating the functional heterogeneity of the default mode network using coordinate-based meta-analytic modeling[J].J Neurosci,2009,29(46):14496-14505.
-
计量
- 文章访问数: 511
- PDF下载数: 170
- 施引文献: 0
下载: