Effect and prognosis analysis of surgical treatment on adrenal incidentalomas patients with hypertension and normally endocrinological assessment
-
摘要: 目的:探讨高血压伴无肾上腺激素生化异常的肾上腺偶发瘤患者行肾上腺占位切除术后高血压的改善效果及影响术后血压改善的相关因素。方法:回顾性分析2014年1月—2017年12月在我院接受肾上腺占位切除术的88例患者的临床、病理资料及随访情况。男50例,女38例,年龄27~76岁,平均(53.61±10.92)岁;肿瘤最大直径中位数为2.4 cm;左侧41例,右侧47例。88例患者均具有高血压病史,术前血浆醛固酮、血浆醛固酮/肾素比值、血浆游离皮质醇、尿儿茶酚胺、血浆甲氧基肾上腺素、血浆甲氧基去甲肾上腺素、电解质等均正常。随访患者术后1年的血压改善情况以及控制血压的服药量。将术后血压恢复正常或控制血压的服药量减少的患者作为观察组,将术后血压与用药无明显变化的患者作为对照组,根据logistic回归分析探讨影响术后血压改善的相关因素。结果:88例患者中,术后血压恢复正常或控制血压的服药量减少的患者有70例,术后血压与用药无明显变化的患者有18例,高血压的改善率为79.5%。观察组70例患者术后病理类型分别为:肾上腺皮质腺瘤48例(68.57%),嗜铬细胞瘤12例(17.14%),髓脂肪瘤5例(7.14%),肾上腺结节性增生3例(4.29%),节细胞神经瘤2例(2.86%);对照组18例患者术后病理类型分别为:肾上腺皮质腺瘤17例(94.44%),嗜铬细胞瘤1例(5.56%)。两组患者临床资料分析显示,观察组与对照组相比,年龄、术前血压、血浆醛固酮、血浆醛固酮/肾素比值、血浆游离皮质醇、血浆甲氧基肾上腺素、血浆甲氧基去甲肾上腺素、肿瘤最大直径、肿瘤偏侧、ASA分级差异无统计学意义(P>0.05),而两组患者的性别比例和BMI比较差异有统计学意义(P<0.05)。logistic回归分析显示BMI(OR=1.312,95%CI:1.064~1.617,P=0.011)是影响术后血压改善的独立因素。BMI较低者,术后血压改善情况更好。结论:本研究认为,对于高血压伴无肾上腺激素生化异常的肾上腺偶发瘤患者,手术治疗可使一部分患者显著获益,尤其是对于BMI较低(BMI≤25 kg/m2)的患者,手术治疗指征可适当放宽。Abstract: Objective: To investigate the effect of adrenal surgery on blood pressure in adrenal incidentalomas patients with normally endocrinological assessment and to assess factors affecting hypertension outcomes after surgery.Methods: Data of 88 patients who underwent partial adrenalectomy between Jan. 2014 and Dec. 2017 were studied. There were 50 males and 38 females, whose age ranged from 27 to 76 years old, with an average age of(53.61 ±10.92) years. The median diameter of the tumor was 2.4 cm, 41 cases on the left side and 47 cases on the right side. All the 88 patients had a history of hypertension. In preoperative assessment, plasma aldosterone, plasma aldosterone to renin ratio, plasma free cortisol, urinary catecholamine,plasma metanephrine,plasma normetanephrine, electrolytes were normal. The postoperative blood pressure and the dose of anti-hypertension drugs were followed up for one year. The patients whose postoperative blood pressure returned to normal or dose of anti-hypertension drugs were reduced were regarded as the observation group, while the patients with no improvement in blood pressure as the control group. Factors affecting hypertension outcomes after surgery were determined using logistic regression.Results: A total of 88 patients, 70 patients had returned to normal blood pressure or reduced the dose of anti-hypertension drugs, while 18 patients had no significant change in blood pressure after operation, and the improvement rate was 79.5%. The postoperative pathological types of 70 patients in the observation group were adrenocortical adenoma 48 cases(68.57%), pheochromocytoma 12 cases(17.14%), myelolipoma 5 cases(7.14%), adrenal nodular hyperplasia 3 cases(4.29%), ganglioneuroma 2 cases(2.86%). The postoperative pathological types of 18 patients in the control group were 17 cases of adrenocortical adenoma(94.44%) and 1 case of pheochromocytoma(5.56%). The analyses of clinical data of the two groups showed that there was no significant difference in age, preoperative blood pressure, plasma aldosterone, plasma aldosterone to renin ratio, plasma free cortisol, plasma metanephrine, plasma normetanephrine, maximum diameter of tumor, tumor laterality or ASA grade(P>0.05), but there was significant difference in sex ratio and BMI between the two groups(P<0.05). Logistic regression analyses showed that BMI(OR=1.312, 95%CI: 1.064-1.617, P=0.011) was the only independent factor associated with favorable postoperative hypertension.Conclusion: Surgical treatment can improve concomitant hypertension in most patients with adrenal incidentaloma without biochemical abnormalities, especially for patients with low BMI(BMI≤25 kg/m2).
-
Key words:
- hypertension /
- adrenal incidentaloma /
- surgical treatment
-
[1] 蒋绍博.肾上腺源性高血压的外科诊治新模式[J].中国医刊,2017,52(11):4-7.
[2] Cingolani OH.Cardiovascular Risks and Organ Damage in Secondary Hypertension[J].Endocrinol Metab Clin North Am,2019,48(4):657-666.
[3] Androulakis II,Kaltsas GA,Kollias GE,et al.Patients with apparently nonfunctioning adrenal incidentalomas may be at increased cardiovascular risk due to excessive cortisol secretion[J].J Clin Endocrinol Metab,2014,99(8):2754-2762.
[4] Ribeiro Cavalari EM,de Paula MP,Arruda M,et al.Nonfunctioning adrenal incidentaloma:A novel predictive factor for metabolic syndrome[J].Clin Endocrinol(Oxf),2018,89(5):586-595.
[5] Peppa M,Koliaki C,Raptis SA.Adrenal incidentalomas and cardiometabolic morbidity:an emerging association with serious clinical implications[J].J Intern Med,2010,268(6):555-566.
[6] Peppa M,Boutati E,Koliaki C,et al.Insulin resistance and metabolic syndrome in patients with nonfunctioning adrenal incidentalomas:a cause-effect relationship?[J].Metabolism,2010,59(10):1435-1441.
[7] Fassnacht M,Arlt W,Bancos I,et al.Management of adrenal incidentalomas:European Society of Endocrinology Clinical Practice Guideline in collaboration with the European Network for the Study of Adrenal Tumors[J].Eur J Endocrinol,2016,175(2):G1-G34.
[8] Elhassan YS,Alahdab F,Prete A,et al.Natural History of Adrenal Incidentalomas With and Without Mild Autonomous Cortisol Excess:A Systematic Review and Meta-analysis[J].Ann Intern Med,2019,171(2):107-116.
[9] Lopez D,Luque-Fernandez MA,Steele A,et al."Nonfunctional" Adrenal Tumors and the Risk for Incident Diabetes and Cardiovascular Outcomes:A Cohort Study[J].Ann Intern Med,2016,165(8):533-542.
[10] Arruda M,Mello Ribeiro Cavalari E,Pessoa de Paula M,et al.The presence of nonfunctioning adrenal incidentalomas increases arterial hypertension frequency and severity,and is associated with cortisol levels after dexamethasone suppression test[J].J Hum Hypertens,2017,32(1):3-11.
[11] Tuna MM,Imga NN,Doǧan BA,et al.Non-functioning adrenal incidentalomas are associated with higher hypertension prevalence and higher risk of atherosclerosis[J].J Endocrinol Invest,2014,37(8):765-768.
[12] Di Dalmazi G,Vicennati V,Garelli S,et al.Cardiovascular events and mortality in patients with adrenal incidentalomas that are either non-secreting or associated with intermediate phenotype or subclinical Cushing's syndrome:a 15-year retrospective study[J].Lancet Diabetes Endocrinol,2014,2(5):396-405.
[13] Akkan T,Altay M,Ünsal Y,et al.Nonfunctioning adrenal incidentaloma affecting central blood pressure and arterial stiffness parameters[J].Endocrine,2017,58(3):513-520.
[14] Hong AR,Kim JH,Park KS,et al.Optimal follow-up strategies for adrenal incidentalomas:reappraisal of the 2016 ESE-ENSAT guidelines in real clinical practice[J].Eur J Endocrinol,2017,177(6):475-483.
[15] Papanastasiou L,Alexandraki KI,Androulakis II,et al.Concomitant alterations of metabolic parameters,cardiovascular risk factors and altered cortisol secretion in patients with adrenal incidentalomas during prolonged follow-up[J].Clin Endocrinol(Oxf),2017,86(4):488-498.
[16] Lee JM,Kim MK,Ko SH,et al.Clinical Guidelines for the Management of Adrenal Incidentaloma[J].Endocrinol Metab(Seoul),2017,32(2):200-218.
[17] 那彦群,叶章群,孙颖浩,等.中国泌尿外科疾病诊断治疗指南手册[M].北京:人民卫生出版社,2014:569-570.
[18] Bernini G,Moretti A,Iacconi P,et al.Anthropometric,haemodynamic,humoral and hormonal evaluation in patients with incidental adrenocortical adenomas before and after surgery[J].Eur J Endocrinol,2003,148(2):213-219.
[19] Xu T,Xia L,Wang X,et al.Effectiveness of partial adrenalectomy for concomitant hypertension in patients with nonfunctional adrenal adenoma[J].Int Urol Nephrol,2015,47(1):59-67.
[20] 何溢发,孙传玉,徐可,等.后腹腔镜肾上腺切除术后患者高血压改善情况的相关因素分析[J/OL].泌尿外科杂志(电子版),2015,7(4):19-23.
[21] 何龙,范连慧,黄小龙,等.无功能肾上腺偶发瘤切除对血压的影响[J].武警医学,2015,(7):667-669.
[22] 周智恩,李汉忠,石冰冰.功能静止型嗜铬细胞瘤29例临床分析[J].基础医学与临床,2014,34(2):240-243.
[23] Patel D.Surgical approach to patients with pheochromocytoma[J].Gland Surg,2020,9(1):32-42.
[24] Timmers HJ,Brouwers FM,Hermus AR,et al.Metastases but not cardiovascular mortality reduces life expectancy following surgical resection of apparently benign pheochromocytoma[J].Endocr Relat Cancer,2008,15(4):1127-1133.
[25] 夏漫城,双卫兵.浅析肾上腺髓样脂肪瘤[J/OL].泌尿外科杂志(电子版),2017,9(4):4-8.
[26] Adapa S,Naramala S,Gayam V,et al.Adrenal Incidentaloma:Challenges in Diagnosing Adrenal Myelolipoma[J].J Investig Med High Impact Case Rep,2019,7:2324709619870311.
[27] 程亮,周亮,李虹,等.肾上腺髓样脂肪瘤合并高血压的临床特点分析[J].西部医学,2019,31(9):1369-1374.
[28] Zarnegar R,Young WF Jr,Lee J,et al.The aldosteronoma resolution score:predicting complete resolution of hypertension after adrenalectomy for aldosteronoma[J].Ann Surg,2008,247(3):511-518.
[29] Bokuda K,Yatabe M,Mizuguchi Y,et al.Body mass index and contralateral ratio predict outcome following unilateral adrenalectomy in primary aldosteronism[J].Hypertens Res,2017,40(12):988-993.
[30] Morisaki M,Kurihara I,Itoh H,et al.Predictors of Clinical Success After Surgery for Primary Aldosteronism in the Japanese Nationwide Cohort[J].J Endocr Soc,2019,3(11):2012-2022.
[31] 胡文斌,张婷,史建国,等.BMI与高血压关联强度剂量-反应关系分析[J].中国卫生统计,2015,32(6):971-974.
[32] 中国高血压防治指南修订委员会,高血压联盟(中国,中华医学会心血管病学分会中国医师协会高血压专业委员会,等.中国高血压防治指南(2018年修订版)[J].中国心血管杂志,2019,24(1):24-56.
计量
- 文章访问数: 313
- PDF下载数: 203
- 施引文献: 0