肾损伤因子-1与肾癌的研究进展

杨嘉祺; 任玉林; 赵立明; 刘军伟

doi:10.13201/j.issn.1001-1420.2021.08.017

肾损伤因子-1与肾癌的研究进展

- 1. 西北民族大学医学部(兰州, 730030);
- 2. 西北民族大学附属医院泌尿外科
基金项目:
2020年西北民族大学中央高校基本科研业务费资助(No:31920200026)

详细信息

通讯作者: 任玉林,E-mail:renyulin1104@163.com

中图分类号: R737.11

收稿日期: 2020-06-21

Research progress of kidney injury molecule-1 and renal carcinoma

- 1. Medical College of Northwest Minzu University, Lanzhou, 730030, China;
- 2. Department of Urology, Affiliated Hospital of Northwest Minzu University

More Information

Corresponding author: REN Yulin, E-mail: renyulin1104@163.com

Received Date: 21 June 2020

摘要

摘要: 肾癌占全球所有癌症的3%,其中肾透明细胞癌(ccRCC)是肾癌的常见类型,肾损伤因子-1(Kim-1)是一种跨膜型Ⅰ型蛋白,在泌尿系统中仅在起源于近端小管的ccRCC和乳头状肾癌的免疫组织化学中表达,基质金属蛋白酶对该分子外部片段的切割导致出现可溶形式的Kim-1,可在尿液或循环血液中表达阳性,且在肾肿瘤的研究中有特异性、敏感性高的特点,本文就Kim-1与ccRCC相关研究作一综述。
- 肾癌 /
- 肾损伤因子-1 /
- 肾损伤因子-1检测方式
Abstract: Renal cell carcinoma accounts for 3% of all cancers in the world. Clear cell renal cell carcinoma(ccRCC) is a common type of renal cell carcinoma. Kidney injury molecule-1(Kim-1) is a transmembrane type Ⅰ protein, which is only expressed in the immunohistochemistry of ccRCC and papillary renal cell carcinoma originating from proximal tubules. The cleavage of the outer fragment of the molecule by matrix metalloproteinases leads to the positive expression of soluble Kim-1 in urine or circulating blood. And it has the characteristics of high specificity and sensitivity in the study of renal tumors. This paper reviews the relationship between Kim-1 and ccRCC.
- renal carcinoma /
- kidney injury molecule-1 /
- detection methods of kidney injury molecule-1

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