机器人辅助腹腔镜前列腺癌根治术治疗高危局部进展期前列腺癌临床疗效分析

陈志华; 蒋国松; 阮海龙; 夏秋翔; 许天波; 章小平

doi:10.13201/j.issn.1001-1420.2022.02.010

机器人辅助腹腔镜前列腺癌根治术治疗高危局部进展期前列腺癌临床疗效分析

- 1.
  新疆生产建设兵团第五师医院泌尿外科(新疆博乐，833400)
- 2.
  华中科技大学同济医学院附属协和医院泌尿外科

详细信息

通讯作者: 章小平，E-mail：1994xh0526@hust.edu.cn

中图分类号: R737.25

收稿日期: 2021-05-21

刊出日期: 2022-02-06

Clinical effect analysis of robot-assisted laparoscopic radical resection of prostate cancer for high-risk locally advanced prostate cancer

- 1.
  Department of Urology, The Fifth Division Hospital, Xinjiang Production and Construction Corps, Bole, Xinjiang, 833400, China
- 2.
  Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

More Information

Corresponding author: ZHANG Xiaoping, E-mail: 1994xh0526@hust.edu.cn

Received Date: 21 May 2021

Publish Date: 06 February 2022

摘要

摘要: 目的探究机器人辅助腹腔镜前列腺癌根治术治疗高危局部进展期前列腺癌的疗效，为临床提供理论参考。方法选取华中科技大学同济医学院附属协和医院泌尿外科2016年1月—2020年10月收治的237例高危局部进展期前列腺癌患者作为研究对象，分为观察组129例和对照组108例。对照组采用常规腹腔镜根治术治疗，观察组经机器人辅助行腹腔镜根治术治疗，比较2组各项临床指标、切缘阳性率、尿控恢复以及围术期并发症率。结果观察组的术中出血量、总住院时间、手术时间、胃肠功能恢复时间、引流管留置时间均短于对照组，差异有统计学意义(P＜0.05)。观察组围术期各种并发症发生率、切缘阳性率、尿控恢复及生化复发相比较，差异无统计学意义(P＞0.05)。结论机器人辅助腹腔镜前列腺癌根治术治疗高危局部进展期前列腺癌具有创伤小、手术时间短及术后恢复快的特点，值得临床推广及应用。
- 前列腺癌 /
- 机器人 /
- 腹腔镜根治术 /
- 疗效 /
- Gleason评分 /
- 并发症
Abstract: Objective To explore the efficacy of robot-assisted laparoscopic radical resection of prostate cancer in the treatment of high-risk locally advanced prostate cancer, and to provide theoretical reference for clinical practice.Methods From January 2016 to October 2020, 237 patients with high-risk locally advanced prostate cancer admitted to department of urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology were selected as the research objects, and divided into observation group (129 cases) and control group (108 cases). The control group was treated with conventional laparoscopic radical prostatectomy, and the observation group was treated with robot-assisted laparoscopic radical prostatectomy. The clinical indicators, Gleason score decline rate, clinical staging degradation rate, perioperative complication rate of the two groups were compared.Results The duration of operation, intraoperative blood loss, recovery time of gastrointestinal function, indwelling time of drainage tube and hospitalization time in the observation group were shorter than those in the control group, with statistical significance (P < 0.05). There were no significant differences in the incidence of perioperative complications, positive margin rate, recovery of urinary control or biochemical recurrence between two groups (P > 0.05).Conclusion Robot-assisted laparoscopic radical resection of prostate cancer for high-risk locally advanced prostate cancer has the characteristics of small trauma, short operation time and quick postoperative recovery, which is worthy of clinical promotion and application.
- prostate cancer /
- robot /
- laparoscopic radical resection /
- curative effect /
- Gleason scores /
- complications

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表 1 2组围术期指标比较 X±S

组别	手术时间/min	术中出血量/mL	引流管留置时间/d	胃肠功能恢复时间/d	住院时间/d
对照组(n=108)	123.90±17.65	235.81±36.09	14.28±2.63	2.06±0.64	8.23±1.48
观察组(n=129)	116.37±16.28	167.42±27.18	10.87±2.50	1.85±0.57	7.05±1.22
t	3.413	15.488	2.230	2.668	6.700
P值	0.001	＜0.001	0.006	0.008	＜0.001

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表 2 2组围术期并发症及切缘阳性比较例(%)

组别	大出血	直肠损伤	心脑血管并发症	切缘阳性
对照组(n=108)	3(2.78)	2(1.85)	1(0.93)	38(35.2)
观察组(n=129)	2(1.55)	1(0.76)	2(0.76)	45(34.9)
χ²	1.351	1.865	0.346	0.701
P值	0.245	0.172	0.556	0.402

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表 3 2组尿控恢复及生化复发比较例(%)

组别	尿控恢复	生化复发
对照组(n=83)	78(94.0)	27(32.5)
观察组(n=106)	101(95.3)	32(30.2)
χ²	0.159	0.119
P值	0.690	0.730

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